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eaeA

Victor ID 3492
Gene Name eaeA
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7063868
NCBI Protein GI 215488970
Locus Tag E2348C_3939
Protein Accession YP_002331401.1
Other Database IDs UniProtKB-ID: EAE_ECO27
UniRef100: UniRef100_P19809
UniRef90: UniRef90_P19809
UniRef50: UniRef50_P19809
UniParc: UPI000187BE48
EMBL: M58154
EMBL: AF022236
EMBL: FM180568
EMBL-CDS: AAA62775.1
EMBL-CDS: AAC38392.1
EMBL-CDS: CAS11487.1
RefSeq_NT: NC_011601.1
PDB: 1E5U
PDB: 1F00
PDB: 1F02
EnsemblGenome: EBESCG00000115379
EnsemblGenome_TRS: EBESCT00000112066
EnsemblGenome_PRO: EBESCP00000106277
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3939
HOGENOM: HBG468012
OMA: DINGTER
ProtClustDB: CLSK334542
Taxonomy ID 574521
Gene Starting Position 4110342
Gene Ending Position 4113161
Gene Strand (Orientation) -
Protein Name intimin EaeA
DNA Sequence 
>gi|215485161:4110342-4113161 Escherichia coli O127:H6 str. E2348/69, complete genome
TTTATTTTACACAAGTGGCATAAGCATTAGATTCACTAGCCTTAATATTATTCAGAGGGTTTTGTTTAAC
TAAATCGTATGTACTTGCAACACCACTCTTCGCATCTTGAGCTGTTTGTTGTACCCATGAAATTATAGTC
TGACTAGACTTATAATATTCATATTTATTTGCAGCCCCCCATGCTTTAAAGACATTTTCCAGTTCATTCT
GAGAAGACGGCAACTTTCCTCCAAAATTCTTACATGTATTCACAGCATCATTATAGGTCACACGCTTGCT
CATATTAGGAACAATCAGACTATTAGGTGTTGCAATAGTATAAGTTGCAGTTTGATTATCACTTGAGATA
ACGGAAATAGTTGTAGTTCCCTTCTCTTTTAAGGTGACCTGACCAGAAGAAGCATCCACCGAAGCAATTG
CTGGATTTGCTGAGCGCCATGTATATTTTCCGTTACCTCCGCTGGCTTTCAGATTAACTTGACCATATTG
CAACCATACAGTGGGTAACTTCCCTTTAACTCCGGTTCCAACAATTTCAATATTACCGTCATCAATTGTA
AGCGTTGTAAAAAATTCAACTTCAGGTGCTTTGACATCAACGGCGACATCGCTAACACGGGCACTAACGA
GTGATTTTCCTGGAGTTGTCGATGTTAATGTTACTTTGGCATAGCCATTCGTATCCGTTTTTTCAGTGGA
ATTACTTAACTTACCTAAGGTCGTCGTAAAGGTCACTTCCTGATTAGATACAGGCTTATCCCCCTTCATC
ACTTTAACAGTGTATGTAATAGCATCCTGACCATTTGCTACTGCCGTTGTTTTATCAGCCTTAATCTCAG
TAATGCTGGCCTTGGTTTGATCAACAAATATAACTGCATTGGCATTAAGCGCTGAAGTCATCTCTGCTGT
TTTAGCAGACACGACGACCTGGCCTGGTTTATCCGATTTCAGGGTTACAGTCGCCTTACCGCTACCATTG
GTATTGGCACTATTGGCACTTAAAACTGCAGTTCCTGAAACAATATTAAATGAAACAGGGACATTAGCCT
GAGCTACCCCATTCTTTTTCACCGTCGCAGTATAAGTAATTGCTTCGGTGCCATCCGCTTTAGCCGAAGT
CTTATCAGCCGTAAAGTCCGTTACCCCAACCTGGTCGACCACCTGACCATTCGACAGAACGGTAATAGTA
AGCAGTACATTGTTAGAGCTATTGCCATTACGGTCATAGGCGCGAGCCGTCACTTTATAAACATTGCTAC
CACCTTGCACATAAGCAGGCAAAATAGCCTGGTAATCTTGTGCGCTTTGGCTTCCGCTATGCTGAATCTG
GCCGCCCTGGCTACGTAATGCACTATCATCCCAGACGATACGATCCAGACCGTATTTGCTCTTAACGATC
AATTGAATCTTCTGCGTACTGCGTTCAGTACCATTAATATCATGCGGAATATTCAGAGAAAGAATATCCT
GCTTTTTGTACTCCAGAATAATATTGTTATTACGCTGAACCAGATCGTAACGGCTGCCTGATAATGTTCT
TAACTCGTTAACATATTGTGGCTCAATTTGCTGAGACCACGGTTTATCAAACTGATAACGGAACTGCATT
GAGTAAAGGAGATCATTTTCATTACCCGTACCATGACGGTAATCGATCCCCATCGTCACCAGAGGAATCG
GAGTATAGTTTACACCAACGGTCGCCGCACCAGGATTCGACTGCAGCTTATCAGAATTAAACAAAGCAAC
ATTATCACCATAATACTGCTCATACATCAGCTTGGCACCTAATGCCGGGTATGATGGCAGATAGCCATTA
AAACGGATATCGAAGCCATTTGCTGGGCGCTCATCATAGTCTTTCTTATTGTATGACTCATGCCAGCCGC
TCATGCGGAAATAGCCGTTAACACTACTTTTGAAATAGTCTCGCCAGTATTCGCCACCAATACCTAAACG
GGTATTATCACCAGAAAAATCCTGATCAATGAAGACGTTATAGCCCAACATATTTTCAGGAAGGAAAAAA
CGCTGACCCGCACCTAAATTTGCCGTAAAGCGGGAGTCAATGTAACGCGCTCCGACCTGACCAAATGCCA
GCATTTTTTCGGAATCATAGAACGGTAATAAGAAGTCCAGTGAACTACCGTCAAAGTTATTACCACTCTG
CAGATTAACCTCTGCCGTTCCATAATGTTGTAACCAGGCCTGCAACTGTGACGAAGCCTGGTTACCAGCG
ATACCAAGAGCGGTATCTTTCGCGTAATCGCCGTTCAGAGATCGCGACTGAAGCTGGCTACCGAGACTCG
CCGCCTGTTGTGCCGCATAATTTAATGCCTTGTCATCGGTCATGTTGCTTTTGGTCACGTCCGGGGACAT
TTTAGTCAGTTTATTTGTATGACCAGCGACACCACCTGCAGCAACAAGAGGTGCCGAACCTAAAAGTGGT
AAGGCACTGTATTCAAAGGGAAGTTTTTTGAGTGGCAAAATGATCTGCTGACCAGGCGCGGCCTTCATCA
TTTCGCTTTCAGAACTGTATAAATGCTTATTCAACGACCAAATCGTCGATAAATTAATATCTTGCGATTT
AGAAAGATCGGCAACAGTTTCACCTGTTTTCAACGTATAAAAAAGGCGATTCTGATAGCTATTATGAGTT
AACAGTTTTGAATCCGAACCCAATTTAAAATAATTTTCACCATTTGCAAATGAATTCTGATTAACATAAA
AAAACAATCCTAAACCAGCACTAAGCATAATAAATGTTTTTTTTAGCTTATGCTTGTGCCGGGTCCGGGC
ATAAAAACCATGAGTAATCA
Protein Sequence 
>gi|215488970|ref|YP_002331401.1| intimin EaeA [Escherichia coli O127:H6 str. E2348/69] MITHGFYARTRHKHKLKKTFIMLSAGLGLFFYVNQNSFANGENYFKLGSDSKLLTHNSYQNRLFYTLKTGETVADLSKSQDINLSTIWSLNKHLYSSESEMMKAAPGQQIILPLKKLPFEYSALPLLGSAPLVAAGGVAGHTNKLTKMSPDVTKSNMTDDKALNYAAQQAASLGSQLQSRSLNGDYAKDTALGIAGNQASSQLQAWLQHYGTAEVNLQSGNNFDGSSLDFLLPFYDSEKMLAFGQVGARYIDSRFTANLGAGQRFFLPENMLGYNVFIDQDFSGDNTRLGIGGEYWRDYFKSSVNGYFRMSGWHESYNKKDYDERPANGFDIRFNGYLPSYPALGAKLMYEQYYGDNVALFNSDKLQSNPGAATVGVNYTPIPLVTMGIDYRHGTGNENDLLYSMQFRYQFDKPWSQQIEPQYVNELRTLSGSRYDLVQRNNNIILEYKKQDILSLNIPHDINGTERSTQKIQLIVKSKYGLDRIVWDDSALRSQGGQIQHSGSQSAQDYQAILPAYVQGGSNVYKVTARAYDRNGNSSNNVLLTITVLSNGQVVDQVGVTDFTADKTSAKADGTEAITYTATVKKNGVAQANVPVSFNIVSGTAVLSANSANTNGSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQTKASITEIKADKTTAVANGQDAITYTVKVMKGDKPVSNQEVTFTTTLGKLSNSTEKTDTNGYAKVTLTSTTPGKSLVSARVSDVAVDVKAPEVEFFTTLTIDDGNIEIVGTGVKGKLPTVWLQYGQVNLKASGGNGKYTWRSANPAIASVDASSGQVTLKEKGTTTISVISSDNQTATYTIATPNSLIVPNMSKRVTYNDAVNTCKNFGGKLPSSQNELENVFKAWGAANKYEYYKSSQTIISWVQQTAQDAKSGVASTYDLVKQNPLNNIKASESNAYATCVK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in humans (Donnenberg et al., 1993).
References
Donnenberg et al., 1993: Donnenberg MS, Tacket CO, James SP, Losonsky G, Nataro JP, Wasserman SS, Kaper JB, Levine MM. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. The Journal of clinical investigation. 1993; 92(3); 1412-1417. [PubMed: 8376594].