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espA from Escherichia coli O157:H7 str. TW14359

Victor ID 3705
Gene Name espA from Escherichia coli O157:H7 str. TW14359
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8219237
NCBI Protein GI 254795631
Locus Tag ECSP_4671
Protein Accession YP_003080468.1
Other Database IDs UniProtKB-ID: C6UYL3_ECO5T
UniRef100: UniRef100_O69412
UniRef90: UniRef90_O69412
UniRef50: UniRef50_O87743
UniParc: UPI00000D5DCD
EMBL: CP001368
EMBL-CDS: ACT74392.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000166679.
EnsemblGenome_TRS: EBESCT00000167522
EnsemblGenome_PRO: EBESCP00000157892
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_4671
ProtClustDB: CLSK701598
Taxonomy ID 544404
Gene Starting Position 4652283
Gene Ending Position 4652861
Gene Strand (Orientation) -
Protein Name secreted protein EspA
DNA Sequence 
>gi|254791136:4652283-4652861 Escherichia coli O157:H7 str. TW14359, complete genome
GTTATTTACCAAGGGATATTGCTGAAATAGTTCTATATTGTAGAGATTGCACATCAGAACGTGCACTCGT
TAAGAGATTTAATGTATTCGACATTTGCTGAATTTCGAGCTGGCTATTATTCACTACCGTTGTCAGGTTA
TTCGCTTTAGCTGAAATAGCCGCCTTCACTGTTTGCAGATCACCAGCGCTTAAATCACCACTAAGATCAC
GAATACCAGTTACACTTATGTCATTACGTGGATCGTTTATATAGTCAATCACGTCTTGAGGAAGTTTGGC
TTTCGCATTCTTATCAGTGCTACTCTGAACATCAGCAATTTTGGCATCCACAAGATTAGCCATCTTTTGT
GCCGTGGTTGACGCTTTAGATGCCTCATTCATATCAGCAAACTTTGCAATCGACAGATTACTTTGTGCCT
GATACATATAAGAAAACATGAGAATCGCAGCCTGAAAAACACCGAGTTCCTCAAATAGCTTAACCACCTC
ATCCTTCGACATATTACCTAAGTCATAGATCGTCGATGTCGAAGAACTCGCACTCACATTAACAACGGAT
GTTGCATTTGATGTATCCA
Protein Sequence 
>gi|254795631|ref|YP_003080468.1| hypothetical protein EspA [Escherichia coli O157:H7 str. TW14359] MDTSNATSVVNVSASSSTSTIYDLGNMSKDEVVKLFEELGVFQAAILMFSYMYQAQSNLSIAKFADMNEASKASTTAQKMANLVDAKIADVQSSTDKNAKAKLPQDVIDYINDPRNDISVTGIRDLSGDLSAGDLQTVKAAISAKANNLTTVVNNSQLEIQQMSNTLNLLTSARSDVQSLQYRTISAISLGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements (Ebel et al., 1998).
References
Ebel et al., 1998: Ebel F, Podzadel T, Rohde M, Kresse AU, Krämer S, Deibel C, Guzmán CA, Chakraborty T. Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Molecular microbiology. 1998; 30(1); 147-161. [PubMed: 9786192].