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ler from Escherichia coli O157:H7 str. TW14359

Victor ID 3710
Gene Name ler from Escherichia coli O157:H7 str. TW14359
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8219269
NCBI Protein GI 254795663
Locus Tag ECSP_4703
Protein Accession YP_003080500.1
Other Database IDs UniProtKB-ID: C6UYP5_ECO5T
UniRef100: UniRef100_O85645
UniRef90: UniRef90_C7BUR5
UniRef50: UniRef50_Q8VTF2
UniParc: UPI00016C6B7B
EMBL: CP001368
EMBL-CDS: ACT74424.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000169601.
EnsemblGenome_TRS: EBESCT00000167667
EnsemblGenome_PRO: EBESCP00000159008
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_4703
ProtClustDB: CLSK334877
Taxonomy ID 544404
Gene Starting Position 4678930
Gene Ending Position 4679301
Gene Strand (Orientation) -
Protein Name locus of enterocyte effacement (LEE)-encoded regulator
DNA Sequence 
>gi|254791136:4678930-4679301 Escherichia coli O157:H7 str. TW14359, complete genome
GTTAAATATTTTTCAGCGGTATTATTTCTTCTTCAGTGTCCTTCACAAGAAAATCTTCTTTCTTCATTCC
ATTCAACAGTGCTTCTTTAAGCCAGCGTGGCTGTCGGCCTACGCCCGACCAGGTCTGCCCTTCTTCATTG
CGGTAGTAAACACCTTTCGATGAGTTCCGGCGAGCGAGTCCATCATCAGGCACATTAGTATATCCCAGCT
CTTGTAAGGTTATATTGTAATAAGTAATCTGCTTCTGAATCGACTCAATTACACTTTGAACTTCCTGCTC
TCGCAGTCGCTTTGCTTCCTGCTGTAGAACTGCAATTTGCTCTATAAGCTGAATGTATGGACTTGTTGTA
TGTGAATTATTTTCCATATTCA
Protein Sequence 
>gi|254795663|ref|YP_003080500.1| enterocyte effacement (LEE)-encoded regulator [Escherichia coli O157:H7 str. TW14359] MNMENNSHTTSPYIQLIEQIAVLQQEAKRLREQEVQSVIESIQKQITYYNITLQELGYTNVPDDGLARRNSSKGVYYRNEEGQTWSGVGRQPRWLKEALLNGMKKEDFLVKDTEEEIIPLKNI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence (Torres et al., 2008).
COG COG2916R, under R: General function prediction only
References
Torres et al., 2008: Torres AG, Slater TM, Patel SD, Popov VL, Arenas-Hernández MM. Contribution of the Ler- and H-NS-regulated long polar fimbriae of Escherichia coli O157:H7 during binding to tissue-cultured cells. Infection and immunity. 2008; 76(11); 5062-5071. [PubMed: 18794291].