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tir from Escherichia coli (strain: A, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea

Victor ID 3688
Gene Name tir from Escherichia coli (strain: A, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea
Sequence Strain (Species/Organism) Escherichia coli (strain: A, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined
NCBI Gene ID 8319255
NCBI Protein GI 256367770
Locus Tag pEK499_p062
Protein Accession YP_003108327.1
Other Database IDs UniProtKB-ID: Q7B3U8_ECOLX
UniRef100: UniRef100_P13974
UniRef90: UniRef90_P13974
UniRef50: UniRef50_P13974
UniParc: UPI0000000F55
EMBL: AF550679
EMBL: AY458016
EMBL: DQ364638
EMBL: CP001232
EMBL: EU935739
EMBL: GU371928
EMBL: GU371929
EMBL: AM886293
EMBL-CDS: AAO49556.1
EMBL-CDS: AAR25126.1
EMBL-CDS: ABD60060.1
EMBL-CDS: ACJ63598.1
EMBL-CDS: ACQ42034.1
EMBL-CDS: ADL14068.1
EMBL-CDS: ADL14178.1
EMBL-CDS: CAP07761.1
RefSeq_NT: NC_004998.1
RefSeq_NT: NC_005327.1
RefSeq_NT: NC_009133.1
RefSeq_NT: NC
Taxonomy ID 562
Plasmid No pEK499
Gene Starting Position 45407
Gene Ending Position 46060
Gene Strand (Orientation) +
Protein Name inner membrane protein
DNA Sequence 
>gi|256367708:45407-46060 Escherichia coli plasmid pEK499, complete sequence
AATGATTCAAACACGTAATCAATATCTGCAGTTTATGCTGGTTATGCTGGCTGCATGGGGCATTAGTTGG
GGAGCCAGATTTGTCATGGAGCAGGCCGTTCTGCTTTATGGATCAGGAAAAAACTATTTGTTCTTCAGTC
ATGGTACTGTTCTGATGTACCTGCTGTGTGTTTTCCTGGTATACCGCCGTTGGATAGCTCCGCTACCGGT
CGTTGGTCAGCTGCGCAACGTTGGCGTACCGTGGCTGGTCGGTGCGATGGCCGTGGTGTATGTCGGTGTA
TTTCTGCTCGGTAAGGCGCTGGCTCTGCCTGCTGAGCCATTTATGACGAAACTTTTTGCCGATAAGTCCA
TACCTGACGTGATCCTGACGTTGCTGACCATCTTTATCCTTGCCCCGTTGAATGAGGAAACGCTGTTCCG
GGGGATTATGCTGAACGTCTTCCGTTCACGGTACTGCTGGACGATGTGGCTGGGGGCGCTGATAACGTCG
TTGTTGTTCGTCGCCGCGCACAGCCAGTATCAGAACCTGCTGACACTGGCAGAACTGTTCCTGGTGGGGT
TGATTACATCAGTGGCCAGGATCAGAAGTGGTGGCCTGCTGCTGCCGGTATTGCTGCATATGGAAGCAAC
CACGCTGGGTTTACTGTTTGGTTG
Protein Sequence 
>gi|256367770|ref|YP_003108327.1| inner membrane protein [Escherichia coli] MIQTRNQYLQFMLVMLAAWGISWGARFVMEQAVLLYGSGKNYLFFSHGTVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVPWLVGAMAVVYVGVFLLGKALALPAEPFMTKLFADKSIPDVILTLLTIFILAPLNEETLFRGIMLNVFRSRYCWTMWLGALITSLLFVAAHSQYQNLLTLAELFLVGLITSVARIRSGGLLLPVLLHMEATTLGLLFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].