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sat from Escherichia coli UMN026

Victor ID 3501
Gene Name sat from Escherichia coli UMN026
Sequence Strain (Species/Organism) Escherichia coli UMN026
NCBI Gene ID 7155292
NCBI Protein GI 218706521
Locus Tag ECUMN_3367
Protein Accession YP_002414040.1
Other Database IDs UniProtKB-ID: B7NCM9_ECOLU
UniRef100: UniRef100_Q8FDW4
UniRef90: UniRef90_Q8FDW4
UniRef50: UniRef50_O32591
UniParc: UPI00000DF015
EMBL: CU928163
EMBL-CDS: CAR14529.1
RefSeq_NT: NC_011751.1
MEROPS: S06.004
EnsemblGenome: EBESCG00000115610.
EnsemblGenome_TRS: EBESCT00000119675
EnsemblGenome_PRO: EBESCP00000111857
GenomeReviews: CU928163_GR
HOGENOM: HBG467630
OMA: RDINGES
ProtClustDB: CLSK2519782
BioCyc: ECOL585056:ECUMN_3367-MONOMER
Taxonomy ID 585056
Gene Starting Position 3479460
Gene Ending Position 3483359
Gene Strand (Orientation) -
Protein Name Serine protease precursor (Secreted autotransporter toxin)
DNA Sequence 
>gi|218703261:3479460-3483359 Escherichia coli UMN026, complete genome
ATCAGAAAGAGTAACGGAAGTTGGCGTTGATCGCGTTATCCACGTTGTATTTACCAAATGCCGATTTCTC
AAACTCAAGACCGAAGCGAAGATTATCGCGAATTTCGGCGTTGAGACCAACATTCATGAGCATACGACCG
TCTTTTTCACCTTTGATACGTTTCTCACCGGACGCATCACGCAGTACGGTTTCACCGTTGGCAAACAGGT
CAAACTGGTAGCCAAGGCCGGCGCGGGCTGTGACTTTCCAGTCCTTACCGGAGAAGGATTTACCCACATC
AACACCGGTACGCCCAATCAGCGGATTAAAGTCCTTATCCTTCATGGTGAGGTTCATTCCCTGGTCCTTC
CAGGAGAACTGTTTCCCGGATACAGCACCGTAAACAAGTTCCGCCTGCGGCTCAATCCATGCAGAGTCAG
TTACATGGTAACGGTAACCGACTTCCGCACCGGCATACCAGGAGTGGGAGCTGTAGTCTCTGGTGCCAAG
GCCGGCGAAAGTTGCGGTATACTCGTTGTCATGGTGAACGTACTTACCGATGAGGTCGATATATGCTCCG
GACTCAAACATGGCAGAGGCATAGAGACCGGCACCCACAGACTTCGTTTCACCACTGAAGGCATCACTGC
CTGCATGGCTGTCGGTATAGGTCATGGTCACCCCGGTGAAGAGGTCAAGGCCATCGAGTTCATGTTTGTT
ATCCGCACCGACCTGAACGTGGGTGTAGTTGTCACTGAATCCACCGCCGGCAGACCCGGTTCCGCTAATG
ATTCGGGCCCATGCACCGGACTCACCGTTAATGTCACGCAGATCACCCATACGTTTGTTAAGGTTGTTGA
CCTCAGCAAGGAAGGCTTTATAGCCGCCTGACATCAGTAATGTTGCCTTTTTAGCCGCATCGGCGTTGGC
CACAGATTTATAGCCGATCAGAGTCCATGTTGCTTTGTCTGTATCGTTCTTTTGCTCGATAACCGGTGTT
ACATCACTGAAGCCAATACTCCGAGTCGTAGCTTTAAAGACATCTACTGCAGTTCCTTTTGGTGCGCTGA
CCAGATCGATATTCAGTCCGTTGCTGTTTCCATTTTTCTCAATGAAGTCGACTAACAGAAGGTTGTTTTT
ACCAGACAACGATTTATTGACAACAAGCTGATCTGCTTGGGCCAGATTTGCACGCAGCACAAATGCACTG
TCATCTATAGTAAGGTTGTTCACTGTAAGGGTTGTAAACTTCCCATTATCACCAGTAAAACGCACCATAC
TGTCTTTTGTTTCTAGACGATTAATTGATGACTGGCTATTTAGATGCCAGATCGCATTATTCATGCTAAC
TGTAGCTTTGGGGGCTGTTATTGCGCCTCGATAAGCGGTATCAAAGCCATACAAAAGAGTCTCTGCCCAT
GCCTGATAAGCAGACGATATAGTCGGTGTTTCAGTTTCAGGCTGTCCCAGAGTAATGGTTGCTGCATCAT
CAGCATAAATATTTCCGGTGACAGATGCCATATTTCTGGCAATGAAATTTGCATTTCCACCACTCAGCCT
GAATCCATCAGCAGCGTAGTGGAGACCCGGCGTTACAGTTTTACTATTCTGTTCAGGGATTCCCATCATA
GTCAGTTCACCGGAGATATCAATACCTTTTGTTGTGAACATGGAATTTTGTGCTATAACTTTTGCTCCTT
TATCTATACTTATAGGAGTATTATCCAGAAAGGTTGCACCATTAAGTGTAACTACAGCTTGATCACCTAT
GGCTATTTGGCTGTTATGTGCAGTGATGCCACCTGTAAATTTAGTTTCTCCTATGGATAGATTAGTACTG
ATAGTTTGTTTGAAGTCAAAACCATTATTAGTAATATTTTTCCCTGCAAGATTATCAATGTAAACATTTT
TATCGCCGATTGTGATAGCTGATTTATTTGCTGATATATTTCCTTCAACATTGGCATTGCGTGATATTGA
AAAGTCAGCATTGTTCAGGTGTAATGTATCAAATTTAAACACCCCGGTTTTCCAGTCAGGCTGATCAAAT
GAGGTCTGCTGATTATTACTTTTGTAATCAGAATTGAACTTTTTATTATATGAACTCTCTGTTTCTTTCA
AAACGGTGACCCAGTCCGTTCCACAAAGAAATACCAGGGAGCAATGATTCGCTGAGCTTCTGAATATTGC
ATGCTCTGTTGCATGGCCTTGCATGGTAAGACTGGCATTACTGACTTCAACATCATTTTTTGTGTTGACA
CTACCATCCAGAATTAATTTTGCATTAGTTTTCTTATCCTGAGAATTAATATTGTGTGTTAGTTTTATAT
TGCCATTTATGTTCCCATGATATATGTAGGAGTCTTCGTTATTGATTGCCAGAACGGCTTCTTTCGTTGT
ATCTGAGTTAGTTATTGTTGTTCCATCGTCAGTGGCGGCAATTCTAGTAAAAGTCTGATTGTGTCCATTT
AAATCTAGCGTACCACCACGTTTAGTAAAAAATATCCCCGCATATTGATCATTGCCAAGGGAATTATCTT
TATTTAGTATTACCTTACCATTTCCGCTTGCAAGGTATATATTGTTAAATGTTCCTTCTTCATTAAGAAT
AACATTTCCTTCACCTATCTTTATATTTGCCCCCTGTTTTTTTTGAACATTCAGAGTACCAGGGCCTATT
TTGTGTAAAACATCATCACTGGAATACAATGCATTCCAGTTTACAATGCTTTCTTTTCCGATATCAATTC
CTGCTCCTTTAAATGTAAATCCCTGACCGTTTATGTTATATTCATGGCCTTCGTCAAAGATAATACCACC
GCTACCAAAATCCAAATTATCCTTAAACAGGACATCTCCCCCATTTGTGAACACAATATCTTTGTCTTTA
GTTATTTTTTCTTGAGTACCAGTGGTATCTGCATTGTTTTGGTGTAATGTTATATCTGTGTTTTTAATGG
TTACATTATTGCCATTCAGATTTATTTTATGACTATAGGTATCTTTTAACTCACTAACCAGTTTATCATT
GTATTTTGTTATCCATGTCAGTTGGTCACCATTAACGCTGGCAATACCATGGGTTGTTCCGACTAATACC
CATTTTTCTAGTTTGTTATCATATAAGTATGCTCCAGAGCCGCTGTCTCCGAATATTTCAAGATTACGAA
ATGTTTTATCATTTTTATAAATCATCATGCCGTATGAGTCCCATTGGGTGACCTCAAATAGACTAGCACT
TAACAGATCATGGCTATATGCTGAATTTGTTGAGATTTTGGATTCACCATTAATAAATGATGTTCCTCCA
GAGCCAGCACGAAAACCTATGATTTTTTTTGAACCGTCAGAAGTGACTATACCGTAGCGTTCTAATGCAT
CAGAATATGTTGTAGGGTTGGTCTCTGCCGGGGTGGCACCTACTGTTTCCACAACAAATTTATTTAACCT
CTGAATCTCAAAATCATTGGAATTTCTTCTGTCAACAACCCTGTAAGAAGACTGAGCGTAAACCTGGGTT
TCTGCGGCCTGAGGGTTCTTTTTGTTATGTGCAACAGTAACACTATAAGAACCTCCTATTGCGGTAGCTG
CGCCACTCGCTGCTGCACCAGAAAAATCCGGAATTGAGAGATTATGGAAAGAGAATTTATCTCCGTTTTT
TAAAGTGATTGTTACGTCTGTTGCTCCGGGCTGGAAAATACCTTTATTTTGTGCAAGATCAAGATAGTCT
CTCGCCCATACATTTGATATATCAATATTTGCTGCATTTACTGTACCGGCAACAGCCAGAGACAACATTG
TTGCTACAAGTTTTCGGTTTGTTTTACCAGAAACTCTTTTCGCTAATTCAGAAACAGCAATGAGTCCGCC
AGTGGCAGCACTATATTTAAGGGAGTATATTTTATTCATATATTCTCTCA
Protein Sequence 
>gi|218706521|ref|YP_002414040.1| Serine protease [Escherichia coli UMN026] MREYMNKIYSLKYSAATGGLIAVSELAKRVSGKTNRKLVATMLSLAVAGTVNAANIDISNVWARDYLDLAQNKGIFQPGATDVTITLKNGDKFSFHNLSIPDFSGAAASGAATAIGGSYSVTVAHNKKNPQAAETQVYAQSSYRVVDRRNSNDFEIQRLNKFVVETVGATPAETNPTTYSDALERYGIVTSDGSKKIIGFRAGSGGTSFINGESKISTNSAYSHDLLSASLFEVTQWDSYGMMIYKNDKTFRNLEIFGDSGSGAYLYDNKLEKWVLVGTTHGIASVNGDQLTWITKYNDKLVSELKDTYSHKINLNGNNVTIKNTDITLHQNNADTTGTQEKITKDKDIVFTNGGDVLFKDNLDFGSGGIIFDEGHEYNINGQGFTFKGAGIDIGKESIVNWNALYSSDDVLHKIGPGTLNVQKKQGANIKIGEGNVILNEEGTFNNIYLASGNGKVILNKDNSLGNDQYAGIFFTKRGGTLDLNGHNQTFTRIAATDDGTTITNSDTTKEAVLAINNEDSYIYHGNINGNIKLTHNINSQDKKTNAKLILDGSVNTKNDVEVSNASLTMQGHATEHAIFRSSANHCSLVFLCGTDWVTVLKETESSYNKKFNSDYKSNNQQTSFDQPDWKTGVFKFDTLHLNNADFSISRNANVEGNISANKSAITIGDKNVYIDNLAGKNITNNGFDFKQTISTNLSIGETKFTGGITAHNSQIAIGDQAVVTLNGATFLDNTPISIDKGAKVIAQNSMFTTKGIDISGELTMMGIPEQNSKTVTPGLHYAADGFRLSGGNANFIARNMASVTGNIYADDAATITLGQPETETPTISSAYQAWAETLLYGFDTAYRGAITAPKATVSMNNAIWHLNSQSSINRLETKDSMVRFTGDNGKFTTLTVNNLTIDDSAFVLRANLAQADQLVVNKSLSGKNNLLLVDFIEKNGNSNGLNIDLVSAPKGTAVDVFKATTRSIGFSDVTPVIEQKNDTDKATWTLIGYKSVANADAAKKATLLMSGGYKAFLAEVNNLNKRMGDLRDINGESGAWARIISGTGSAGGGFSDNYTHVQVGADNKHELDGLDLFTGVTMTYTDSHAGSDAFSGETKSVGAGLYASAMFESGAYIDLIGKYVHHDNEYTATFAGLGTRDYSSHSWYAGAEVGYRYHVTDSAWIEPQAELVYGAVSGKQFSWKDQGMNLTMKDKDFNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLFANGETVLRDASGEKRIKGEKDGRMLMNVGLNAEIRDNLRFGLEFEKSAFGKYNVDNAINANFRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Sat elicits cytopathic activity that damages host tissue and may increase the ability of E. coli to propagate (Guyer et al., 2002).
COG COG4625S, under S: Function unknown
References
Guyer et al., 2002: Guyer DM, Radulovic S, Jones FE, Mobley HL. Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. Infection and immunity. 2002; 70(8); 4539-4546. [PubMed: 12117966].