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ilvG

Victor ID 2179
Gene Name ilvG
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 960401
NCBI Protein GI 15804359
Locus Tag Z5279
Genbank Accession AE005174
Protein Accession NP_290399
Other Database IDs UniProtKB-ID: Q8XAV4_ECO57
UniRef100: UniRef100_C3SKW8
UniRef90: UniRef90_P00892
UniRef50: UniRef50_P00892
UniParc: UPI00000D067A
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG58963.1
EMBL-CDS: BAB38125.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
HSSP: P07342
EnsemblGenome: EBESCG00000025503.
EnsemblGenome_TRS: EBESCT00000026450
EnsemblGenome_PRO: EBESCP00000025343
EnsemblGenome: EBESCG00000059164.
EnsemblGenome_TRS: EBESCT00000060117
EnsemblGenome_PRO: EBESCP00000057945
GenomeReviews: AE005174
Taxonomy ID 155864
Gene Starting Position 4812984
Gene Ending Position 4814630
Gene Strand (Orientation) +
Protein Name acetolactate synthase 2 catalytic subunit
Protein pI 5.07
Protein Weight 54935.34
Protein Length 548
Protein Note catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
DNA Sequence 
>gi|16445223:4812984-4814630 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
TATGAATGGCGCACAGTGGGTGGTACATGCGTTGCGGGCACAGGGTGTGAACACCGTTTTCGGTTATCCG
GGTGGCGCAATTATGCCGGTTTACGATGCATTGTATGACGGCGGCGTGGAGCACTTGCTGTGCCGACATG
AGCAGGGTGCGGCAATGGCGGCTATCGGTTATGCCCGTGCTACCGGCAAAACTGGCGTATGTATCGCCAC
GTCTGGTCCGGGCGCAACCAACCTGATAACCGGGCTTGCGGACGCACTGTTAGATTCTATCCCTGTTGTT
GCCATCACCGGTCAAGTGTCCGCACCGTTTATCGGTACTGACGCATTTCAGGAAGTGGATGTCCTGGGAT
TGTCGTTAGCCTGTACCAAGCACAGCTTTCTGGTGCAGTCGCTGGAAGAGTTGCCGCGCATTATGGCTGA
AGCATTCGACGTTGCCAGCTCAGGTCGTCCTGGTCCGGTTCTGGTCGATATCCCAAAAGATATCCAGTTA
GCCAGCGGCGACCTGGAACCGTGGTTCACCACCGTTGAAAACGAAGTGACTTTCCCACATGCCGAAGTTG
AGCAAGCGCGCCAGATGCTGGCAAAAGCGCAAAAACCGATGCTGTACGTTGGTGGTGGCGTGGGTATGGC
GCAGGCAGTTCCTGCTTTACGAGAATTTCTCGCTACCACAAAAATGCCTGCCACCTGCACGCTGAAAGGG
CTGGGCGCAGTTGAAGCAGATTATCCGTACTATCTGGGCATGCTGGGAATGCATGGCACCAAAGCGGCGA
ACTTCGCGGTGCAGGAGTGCGACTTGCTGATCGCCGTGGGTGCACGTTTTGATGACCGGGTGACCGGCAA
ATTGAACACCTTCGCACCACACGCCAGTGTTATCCATATGGATATCGACCCGGCAGAAATGAACAAGCTG
CGTCAGGCACATGTGGCATTACAGGGTGATTTAAATGCGCTGTTACCAGCATTACAGCAGCCATTAAATA
TCAATGACTGGCAGCAATACTGCGCGCAGCTGCGTGATGAACATGCCTGGCGTTACGACCATCCCGGTGA
CGCTATCTACGCGCCGTTGTTGTTAAAACAACTGTCGGATCGTAAACCTGCGGATTGCGTTGTGACCACA
GATGTGGGGCAGCATCAGATGTGGGCCGCGCAGCACATCGCACACACTCGCCCGGAAAATTTCATTACCT
CCAGCGGCTTAGGCACCATGGGTTTTGGTTTACCGGCGGCGGTTGGCGCGCAAGTCGCGCGACCAAACGA
TACCGTCGTCTGTATCTCCGGTGACGGCTCTTTCATGATGAATGTACAAGAGCTGGGCACCGTAAAACGC
AAGCAGTTACCGTTGAAAATCGTCTTACTCGATAACCAACGGTTAGGGATGGTTCGACAATGGCAGCAAC
TGTTTTTCCAGGAACGATACAGCGAAACCACCCTTACCGATAACCCCGATTTCCTCAAGTTAGCCAGCGC
CTTCGGCATCCCTGGCCAACACATCACCCGTAAAGACCAGGTTGAAGCGGCACTCGACACCATGCTGAAC
AGTGATGGGCCATACCTGCTTCATGTCTCAATCGACGAACTTGAGAACGTCTGGCCGCTGGTGCCGCCTG
GTGCCAGTAATTCAGAAATGTTGGAGAAATTATCATG
Protein Sequence 
>gi|15804359|ref|NP_290399.1| acetolactate synthase 2 catalytic subunit [Escherichia coli O157:H7 str. EDL933]
MNGAQWVVHALRAQGVNTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIAT
SGPGATNLITGLADALLDSIPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAE
AFDVASSGRPGPVLVDIPKDIQLASGDLEPWFTTVENEVTFPHAEVEQARQMLAKAQKPMLYVGGGVGMA
QAVPALREFLATTKMPATCTLKGLGAVEADYPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGK
LNTFAPHASVIHMDIDPAEMNKLRQAHVALQGDLNALLPALQQPLNINDWQQYCAQLRDEHAWRYDHPGD
AIYAPLLLKQLSDRKPADCVVTTDVGQHQMWAAQHIAHTRPENFITSSGLGTMGFGLPAAVGAQVARPND
TVVCISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTDNPDFLKLASA
FGIPGQHITRKDQVEAALDTMLNSDGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvG mutant is attenuated in calves (Dziva et al., 2004).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Dziva et al., 2004: Dziva F, van Diemen PM, Stevens MP, Smith AJ, Wallis TS. Identification of Escherichia coli O157 : H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis. Microbiology (Reading, England). 2004; 150(Pt 11); 3631-3645. [PubMed: 15528651].