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hlyC from Escherichia coli CFT073

Victor ID 2109
Gene Name hlyC from Escherichia coli CFT073
Sequence Strain (Species/Organism) Escherichia coli CFT073
NCBI Gene ID 1039495
NCBI Protein GI 26249404
Locus Tag c3569
Protein Accession NP_755444.1
Other Database IDs UniProtKB-ID: Q8FE02_ECOL6
UniRef100: UniRef100_Q8FE02
UniRef90: UniRef90_Q8FE02
UniRef50: UniRef50_P09985
UniParc: UPI00000DEFF5
EMBL: AE014075
EMBL-CDS: AAN82017.1
RefSeq_NT: NC_004431.1
EnsemblGenome: EBESCG00000039950.
EnsemblGenome_TRS: EBESCT00000040900
EnsemblGenome_PRO: EBESCP00000039249
GenomeReviews: AE014075_GR
KEGG: ecc:c3569
NMPDR: fig|199310.1.peg.3487
HOGENOM: HBG296557
OMA: WALMDAD
ProtClustDB: CLSK862057
Taxonomy ID 199310
Gene Starting Position 3418209
Gene Ending Position 3418883
Gene Strand (Orientation) +
Protein Name Hemolysin C
DNA Sequence 
>gi|26245917:3418209-3418883 Escherichia coli CFT073, complete genome
TTTGGTTTGCTTTTTTTTACCTGCCACCGCAATGAATGCTTTTTTTATGTTAATGTGCGTTATGAAACTA
AATGCAAGAAACATATTTAAAGGATTAATATCGTTCTCTCACAGACTCCGTTTACTTATTCAAGAATATA
ATTTAATTTATAGTGAGCTTATTATGAATATGAACAATCCATTAGAGGTTCTTGGGCATGTATCCTGGCT
CTGGGCCAGTTCCCCATTACACAGAAACTGGCCAGTCTCTTTGTTTGCAATAAATGTATTACCTGCAATA
CGGGCTAACCAATATGCTTTATTAACCCGGGATAATTACCCTGTTGCATATTGTAGTTGGGCTAATTTAA
GTTTAGAAAATGAAATTAAATATCTTAATGATGTTACCTCATTAGTCGCAGAAGACTGGACTTCAGGTGA
TCGTAAATGGTTCATTGACTGGATTGCTCCTTTCGGGGATAACGGTGCCCTGTACAAATATATGCGAAAA
AAATTCCCTGATGAACTATTCCGAGCCATCAGGGTGGATCCCAAAACTCATGTTGGTAAAGTATCAGAAT
TTCACGGAGGTAAAATTGATAAACAGTTAGCGAATAAAATTTTTAAACAATATTACCACGAGTTAATAAC
TGAAGTAAAAAACAAGACAGATTTCAATTTTTCATTAACAGGTTA
Protein Sequence 
>gi|26249404|ref|NP_755444.1| hemolysin C [Escherichia coli CFT073] MVCFFLPATAMNAFFMLMCVMKLNARNIFKGLISFSHRLRLLIQEYNLIYSELIMNMNNPLEVLGHVSWLWASSPLHRNWPVSLFAINVLPAIRANQYALLTRDNYPVAYCSWANLSLENEIKYLNDVTSLVAEDWTSGDRKWFIDWIAPFGDNGALYKYMRKKFPDELFRAIRVDPKTHVGKVSEFHGGKIDKQLANKIFKQYYHELITEVKNKTDFNFSLTG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].