| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
sigF from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
922492
|
|
15842877
|
MT3385 |
|
NP_337914.1 |
RNA polymerase sigma factor SigF |
Virulence factor |
MUTATION: sigF mutant is attenuated in mice [Ref6269:Geiman et al., 2004]. |
14977982
|
|
|
fbpA from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
922599
|
|
15843426
|
MT3911 |
|
NP_338463.1 |
esterase, putative, antigen 85-A |
Virulence factor |
MUTATION: fbpA mutant is attenuated in mice [Ref6270:Copenhaver et al., 2004]. |
15557632
|
|
|
panD from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
922795
|
|
15843213
|
MT3706.1 |
|
NP_338250.1 |
aspartate alpha-decarboxylase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
sigH from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
922907
|
|
15842811
|
MT3320 |
|
NP_337848.1 |
RNA polymerase sigma factor RpoE |
Virulence factor |
MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice [Ref6272:Kaushal et al., 2002]. |
12060776
|
|
|
MT3523 |
Mycobacterium tuberculosis CDC1551 |
923111
|
|
15843010
|
MT3523 |
|
NP_338047.1 |
RNA polymerase sigma factor SigD |
Virulence factor |
MUTATION: sigD mutant is attenuated in human macrophages and mice [Ref6273:Calamita et al., 2005]. |
15659067
|
|
|
hspR from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923545
|
|
15839739
|
MT0368 |
|
NP_334776.1 |
transcriptional regulator HspR |
Virulence factor |
MUTATION: hspR mutant is attenuated in mice [Ref6274:Stewart et al., 2001]. |
11385512
|
|
|
katG from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923602
|
|
15841380
|
MT1959 |
|
NP_336417.1 |
catalase-peroxidase |
Virulence factor |
MUTATION: katG mutant is attenuated in mice and guinea pigs [Ref6275:Li et al., 1998]. |
9534978
|
|
|
sodC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923760
|
|
15839819
|
MT0447 |
|
NP_334856.1 |
superoxide dismutase |
Virulence factor |
MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type [Ref6276:Piddington et al., 2001]. |
11447176
|
|
|
mgtC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923776
|
|
15841281
|
MT1859 |
|
NP_336318.1 |
Mg2+ transport protein |
Virulence factor |
MUTATION: mgtC mutant is attenuated in human macrophages and mice [Ref6277:Buchmeier et al., 2000]. |
10760138
|
|
|
senX3 from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923873
|
|
15839881
|
MT0509 |
|
NP_334918.1 |
sensor histidine kinase SenX3 |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
regX3 from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923874
|
|
15839882
|
MT0510 |
|
NP_334919.1 |
DNA-binding response regulator RegX3 |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
proC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
923905
|
|
15839892
|
MT0520 |
|
NP_334929.1 |
pyrroline-5-carboxylate reductase |
Virulence factor |
MUTATION: proC mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
trpD from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
924178
|
|
15841683
|
MT2248 |
|
NP_336720.1 |
anthranilate phosphoribosyltransferase |
Virulence factor |
MUTATION: trpD mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
lspA from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
924361
|
|
15841006
|
MT1591 |
|
NP_336043.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lspA mutant is attenuated in mice [Ref6280:Rampini et al., 2008]. |
18832305
|
|
|
sigC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
924601
|
|
15841558
|
MT2129 |
|
NP_336595.1 |
RNA polymerase sigma-70 factor, ECF subfamily |
Virulence factor |
MUTATION: sigC mutant is attenuated in mice [Ref6281:Sun et al., 2004]. |
15049808
|
|
|
sigE from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
924814
|
|
15840665
|
MT1259 |
|
NP_335702.1 |
RNA polymerase sigma factor SigE |
Virulence factor |
MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type [Ref6282:Manganelli et al., 2001]. |
11489128
|
|
|
leuD from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
925207
|
|
15842543
|
MT3065 |
|
NP_337580.1 |
isopropylmalate isomerase small subunit |
Virulence factor |
MUTATION: leuD mutant is attenuated in mice [Ref6283:Hondalus et al., 2000]. |
10768986
|
|
|
relA from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
925657
|
|
15842122
|
MT2660 |
|
NP_337159.1 |
GTP pyrophosphokinase |
Virulence factor |
MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism [Ref6284:Primm et al., 2000]. |
10940033
|
|
|
ahpC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
925827
|
|
15841949
|
MT2503 |
|
NP_336986.1 |
alkyl hydroperoxide reductase C |
Virulence factor |
MUTATION: ahpC mutant has decreased survival in unactivated macrophages compared to the wild type [Ref6285:Master et al., 2002]. |
12368447
|
|
|
cysH from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
925884
|
|
15841906
|
MT2462 |
|
NP_336943.1 |
phosphoadenosine phosphosulfate reductase |
Virulence factor |
MUTATION: cysH mutant is attenuated in mice [Ref6286:Senaratne et al., 2006]. |
16553880
|
|
|
mma4 |
Mycobacterium tuberculosis CDC1551 |
925954
|
|
15840045
|
MT0670 |
|
NP_335082.1 |
methoxy mycolic acid synthase 4 |
Virulence factor |
MUTATION: mma4 mutant is attenuated in mice [Ref6287:Dubnau et al., 2000]. |
10844652
|
|
|
sigL from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
926053
|
|
15840142
|
MT0759 |
|
NP_335179.1 |
RNA polymerase sigma factor SigL |
Virulence factor |
MUTATION: sigL mutant is attenuated in mice [Ref6288:Hahn et al., 2005]. |
16199577
|
|
|
erp |
Mycobacterium tuberculosis CDC1551 |
926330
|
|
15843432
|
MT3917 |
|
NP_338469.1 |
exported repetitive protein |
Virulence factor |
MUTATION: erp mutant is attenuated in mice [Ref6289:Berthet et al., 1998]. |
9784137
|
|
|
panC from Mycobacterium tuberculosis CDC1551 |
Mycobacterium tuberculosis CDC1551 |
926524
|
|
15843214
|
MT3707 |
|
NP_338251.1 |
pantoate--beta-alanine ligase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
MT3491.1 |
Mycobacterium tuberculosis CDC1551 |
926547
|
|
15842976
|
MT3491.1 |
|
NP_338013.1 |
hypothetical protein |
Virulence factor |
MUTATION: MT3491.1 mutant is attenuated in survival within macrophages [Ref6290:Pethe et al., 2004]. |
15340136
|
|
|
mprA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885038
|
|
15608121
|
Rv0981 |
|
NP_215496.1 |
MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN) |
Virulence factor |
MUTATION: mprA mutant is attenuated in mice [Ref6291:Zahrt and Deretic, 2001]. |
11675502
|
|
|
dppD |
Mycobacterium tuberculosis H37Rv |
885039
|
|
15610799
|
Rv3663c |
|
NP_218180.1 |
PROBABLE DIPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DPPD |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
PPE31 |
Mycobacterium tuberculosis H37Rv |
885072
|
|
57116920
|
Rv1807 |
|
YP_177653.1 |
PPE FAMILY PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
pks7 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885108
|
|
15608799
|
Rv1661 |
|
NP_216177.1 |
Probable polyketide synthase pks7 |
Virulence factor |
MUTATION: pks7 mutant is attenuated in mice [Ref6293:Rousseau et al., 2003]. |
12855735
|
|
|
pks10 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885112
|
|
15608798
|
Rv1660 |
|
NP_216176.1 |
Possible chalcone synthase pks10 |
Virulence factor |
MUTATION: pks10 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
Rv1710 |
Mycobacterium tuberculosis H37Rv |
885116
|
|
15608848
|
Rv1710 |
|
NP_216226.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
coaA |
Mycobacterium tuberculosis H37Rv |
885120
|
|
15608232
|
Rv1092c |
|
NP_215608.1 |
pantothenate kinase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
argJ |
Mycobacterium tuberculosis H37Rv |
885125
|
|
15608791
|
Rv1653 |
|
NP_216169.1 |
bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
prrA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885209
|
|
15608043
|
Rv0903c |
|
NP_215418.1 |
TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA |
Virulence factor |
MUTATION: prrA mutant is attenuated in murine macrophages [Ref6295:Ewann et al., 2002]. |
11953357
|
|
|
cysH from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885250
|
|
15609529
|
Rv2392 |
|
NP_216908.1 |
phosphoadenosine phosphosulfate reductase |
Virulence factor |
MUTATION: cysH mutants are attenuated in mice [Ref6286:Senaratne et al., 2006]. |
16553880
|
|
|
ompA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885286
|
|
15608039
|
Rv0899 |
|
NP_215414.1 |
OUTER MEMBRANE PROTEIN A OMPA |
Virulence factor |
MUTATION: ompA mutant is impaired in its ability to grow in macrophages and in normal mice, although it was as virulent as the wild type in mice that lack T cells [Ref6296:Raynaud et al., 2002]. |
12366842
|
|
|
Rv3651 |
Mycobacterium tuberculosis H37Rv |
885296
|
|
15610787
|
Rv3651 |
|
NP_218168.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
hemN |
Mycobacterium tuberculosis H37Rv |
885300
|
|
15609525
|
Rv2388c |
|
NP_216904.1 |
coproporphyrinogen III oxidase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2387 |
Mycobacterium tuberculosis H37Rv |
885302
|
|
15609524
|
Rv2387 |
|
NP_216903.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1747 |
Mycobacterium tuberculosis H37Rv |
885311
|
|
15608885
|
Rv1747 |
|
NP_216263.1 |
PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER |
Virulence factor |
MUTATION: Rv1747 mutant is attenuated in mice [Ref6297:Curry et al., 2005]. |
16040957
|
|
|
Rv3631 |
Mycobacterium tuberculosis H37Rv |
885314
|
|
15610767
|
Rv3631 |
|
NP_218148.1 |
POSSIBLE TRANSFERASE (POSSIBLY GLYCOSYLTRANSFERASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1930c |
Mycobacterium tuberculosis H37Rv |
885344
|
|
15609067
|
Rv1930c |
|
NP_216446.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0986 |
Mycobacterium tuberculosis H37Rv |
885364
|
|
15608126
|
Rv0986 |
|
NP_215501.1 |
PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER |
Virulence factor |
MUTATION: Rv0986 mutant is attenuated in survival within macrophages [Ref6290:Pethe et al., 2004]. |
15340136
|
|
|
Rv3616c |
Mycobacterium tuberculosis H37Rv |
885377
|
|
15610752
|
Rv3616c |
|
NP_218133.1 |
CONSERVED HYPOTHETICAL ALANINE AND GLYCINE RICH PROTEIN |
Virulence factor |
MUTATION: Rv3616c mutant is attenuated in mice [Ref6298:Fortune et al., 2005]. |
16030141
|
|
|
pepD from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885382
|
|
15608123
|
Rv0983 |
|
NP_215498.1 |
PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B) |
Virulence factor |
MUTATION: pepD mutant has altered virulence in mouse model of infection [Ref6299:White et al., 2010]. |
20061478
|
|
|
lysS |
Mycobacterium tuberculosis H37Rv |
885428
|
|
15608778
|
Rv1640c |
|
NP_216156.1 |
lysyl-tRNA synthetase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1931c |
Mycobacterium tuberculosis H37Rv |
885437
|
|
15609068
|
Rv1931c |
|
NP_216447.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0950c |
Mycobacterium tuberculosis H37Rv |
885438
|
|
15608090
|
Rv0950c |
|
NP_215465.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mgtC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885439
|
|
15608948
|
Rv1811 |
|
NP_216327.1 |
POSSIBLE Mg2+ TRANSPORT P-TYPE ATPASE C MGTC |
Virulence factor |
MUTATION: mgtC mutant is attenuated in human macrophages and mice [Ref6277:Buchmeier et al., 2000]. |
10760138
|
|
|
Rv1111c |
Mycobacterium tuberculosis H37Rv |
885447
|
|
57116830
|
Rv1111c |
|
NP_215627.2 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
panC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885459
|
|
15610738
|
Rv3602c |
|
NP_218119.1 |
pantoate--beta-alanine ligase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
nirA |
Mycobacterium tuberculosis H37Rv |
885472
|
|
15609528
|
Rv2391 |
|
NP_216907.1 |
PROBABLE FERREDOXIN-DEPENDENT NITRITE REDUCTASE NIRA |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1939 |
Mycobacterium tuberculosis H37Rv |
885488
|
|
15609076
|
Rv1939 |
|
NP_216455.1 |
PROBABLE OXIDOREDUCTASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3676 |
Mycobacterium tuberculosis H37Rv |
885502
|
|
15610812
|
Rv3676 |
|
NP_218193.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY) |
Virulence factor |
MUTATION: Rv3676 mutant is attenuated in human macrophages and mice [Ref6300:Rickman et al., 2005]. |
15882420
|
|
|
Rv3701c |
Mycobacterium tuberculosis H37Rv |
885521
|
|
15610837
|
Rv3701c |
|
NP_218218.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
secA2 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885594
|
|
15608958
|
Rv1821 |
|
NP_216337.1 |
preprotein translocase subunit SecA |
Virulence factor |
MUTATION: secA2 mutant is attenuated in mice [Ref6301:Braunstein et al., 2003]. |
12675804
|
|
|
panD from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885596
|
|
15610737
|
Rv3601c |
|
NP_218118.1 |
aspartate alpha-decarboxylase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
Rv3717 |
Mycobacterium tuberculosis H37Rv |
885602
|
|
15610853
|
Rv3717 |
|
NP_218234.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
katG from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885638
|
|
15609045
|
Rv1908c |
|
NP_216424.1 |
CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG |
Virulence factor |
MUTATION: katG mutant is attenuated in mice and guinea pigs [Ref6275:Li et al., 1998]. |
9534978
|
|
|
ahpC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885717
|
|
15609565
|
Rv2428 |
|
NP_216944.1 |
ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) |
Virulence factor |
MUTATION: ahpC mutant has decreased survival in unstimulated macrophages compared to the wild type [Ref6285:Master et al., 2002]. |
12368447
|
|
|
Rv3615c |
Mycobacterium tuberculosis H37Rv |
885770
|
|
15610751
|
Rv3615c |
|
NP_218132.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3615c mutant is attenuated in mice and has growth defects in macrophages [Ref6302:MacGurn et al., 2005]. |
16135231
|
|
|
Rv3614c |
Mycobacterium tuberculosis H37Rv |
885777
|
|
15610750
|
Rv3614c |
|
NP_218131.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3614c mutant is attenuated in mice and has growth defects in macrophages [Ref6302:MacGurn et al., 2005]. |
16135231
|
|
|
Rv3683 |
Mycobacterium tuberculosis H37Rv |
885780
|
|
15610819
|
Rv3683 |
|
NP_218200.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3723 |
Mycobacterium tuberculosis H37Rv |
885791
|
|
15610859
|
Rv3723 |
|
NP_218240.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
recN |
Mycobacterium tuberculosis H37Rv |
885805
|
|
15608834
|
Rv1696 |
|
NP_216212.1 |
PROBABLE DNA REPAIR PROTEIN RECN (RECOMBINATION PROTEIN N) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1524 |
Mycobacterium tuberculosis H37Rv |
885814
|
|
15608662
|
Rv1524 |
|
NP_216040.1 |
Probable glycosyltransferase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1109c |
Mycobacterium tuberculosis H37Rv |
885828
|
|
15608249
|
Rv1109c |
|
NP_215625.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mbtB from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885838
|
|
15609520
|
Rv2383c |
|
NP_216899.1 |
PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE) |
Virulence factor |
MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells [Ref6303:De et al., 2000]. |
10655517
|
|
|
Rv3649 |
Mycobacterium tuberculosis H37Rv |
885841
|
|
15610785
|
Rv3649 |
|
NP_218166.1 |
PROBABLE HELICASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1128c |
Mycobacterium tuberculosis H37Rv |
885849
|
|
15608268
|
Rv1128c |
|
NP_215644.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
glpX |
Mycobacterium tuberculosis H37Rv |
885861
|
|
15608239
|
Rv1099c |
|
NP_215615.1 |
fructose 1,6-bisphosphatase II |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2437 |
Mycobacterium tuberculosis H37Rv |
885906
|
|
15609574
|
Rv2437 |
|
NP_216953.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
hrcA |
Mycobacterium tuberculosis H37Rv |
885924
|
|
15609511
|
Rv2374c |
|
NP_216890.1 |
heat-inducible transcription repressor |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
hspR from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885929
|
|
15607494
|
Rv0353 |
|
NP_214867.1 |
PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL REPRESSOR HSPR (MERR FAMILY) |
Virulence factor |
MUTATION: hspR is attenuated in mice [Ref6274:Stewart et al., 2001]. |
11385512
|
|
|
Rv1144 |
Mycobacterium tuberculosis H37Rv |
885932
|
|
15608284
|
Rv1144 |
|
NP_215660.1 |
PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1974 |
Mycobacterium tuberculosis H37Rv |
885935
|
|
15609111
|
Rv1974 |
|
NP_216490.1 |
PROBABLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mce3A from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885944
|
|
57116931
|
Rv1966 |
|
YP_177852.1 |
MCE-FAMILY PROTEIN MCE3A |
Virulence factor |
MUTATION: mce3A mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
plcA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885995
|
|
15609488
|
Rv2351c |
|
NP_216867.1 |
PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA (MTP40 ANTIGEN) |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
plcB from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
885999
|
|
15609487
|
Rv2350c |
|
NP_216866.1 |
PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
plcC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886000
|
|
15609486
|
Rv2349c |
|
NP_216865.1 |
PROBABLE PHOSPHOLIPASE C 3 PLCC |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
Rv1192 |
Mycobacterium tuberculosis H37Rv |
886007
|
|
15608332
|
Rv1192 |
|
NP_215708.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
furB |
Mycobacterium tuberculosis H37Rv |
886009
|
|
15609496
|
Rv2359 |
|
NP_216875.1 |
PROBABLE FERRIC UPTAKE REGULATION PROTEIN FURB |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
cysE |
Mycobacterium tuberculosis H37Rv |
886012
|
|
15609472
|
Rv2335 |
|
NP_216851.1 |
PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0386 |
Mycobacterium tuberculosis H37Rv |
886030
|
|
15607527
|
Rv0386 |
|
NP_214900.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY) |
Virulence factor |
MUTATION: Rv0386 mutant is attenuated in mice [Ref6306:Paige and Bishai, 2010]. |
20039878
|
|
|
pks16 |
Mycobacterium tuberculosis H37Rv |
886035
|
|
15608153
|
Rv1013 |
|
NP_215529.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1021 |
Mycobacterium tuberculosis H37Rv |
886052
|
|
15608161
|
Rv1021 |
|
NP_215537.1 |
nucleoside triphosphate pyrophosphohydrolase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1184c |
Mycobacterium tuberculosis H37Rv |
886063
|
|
15608324
|
Rv1184c |
|
NP_215700.1 |
POSSIBLE EXPORTED PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadD21 |
Mycobacterium tuberculosis H37Rv |
886065
|
|
15608325
|
Rv1185c |
|
NP_215701.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lpqT |
Mycobacterium tuberculosis H37Rv |
886066
|
|
15608156
|
Rv1016c |
|
NP_215532.1 |
PROBABLE CONSERVED LIPOPROTEIN LPQT |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mmpL10 |
Mycobacterium tuberculosis H37Rv |
886068
|
|
15608323
|
Rv1183 |
|
NP_215699.1 |
PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
kdpD |
Mycobacterium tuberculosis H37Rv |
886084
|
|
15608168
|
Rv1028c |
|
NP_215544.1 |
PROBABLE SENSOR PROTEIN KDPD |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
rfbE |
Mycobacterium tuberculosis H37Rv |
886113
|
|
15610917
|
Rv3781 |
|
NP_218298.1 |
PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER RFBE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
embA |
Mycobacterium tuberculosis H37Rv |
886123
|
|
15610930
|
Rv3794 |
|
NP_218311.1 |
INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBA (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fbpA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886132
|
|
15610940
|
Rv3804c |
|
NP_218321.1 |
SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) (ANTIGEN 85 COMPLEX A) |
Virulence factor |
MUTATION: fbpA mutant is attenuated in mice [Ref6270:Copenhaver et al., 2004]. |
15557632
|
|
|
Rv3805c |
Mycobacterium tuberculosis H37Rv |
886138
|
|
15610941
|
Rv3805c |
|
NP_218322.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
pirG |
Mycobacterium tuberculosis H37Rv |
886139
|
|
15610946
|
Rv3810 |
|
NP_218327.1 |
EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mmpL8 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886145
|
|
15610959
|
Rv3823c |
|
NP_218340.1 |
PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8 |
Virulence factor |
MUTATION: mmpL8 mutant is attenuated in mice [Ref6307:Converse et al., 2003]. |
12724526
|
|
|
Rv3869 |
Mycobacterium tuberculosis H37Rv |
886166
|
|
15611005
|
Rv3869 |
|
NP_218386.1 |
POSSIBLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3865 |
Mycobacterium tuberculosis H37Rv |
886172
|
|
15611001
|
Rv3865 |
|
NP_218382.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3865 mutant is attenuated in mice [Ref6308:Brodin et al., 2006]. |
16368961
|
|
|
sodA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886174
|
|
15610982
|
Rv3846 |
|
NP_218363.1 |
SUPEROXIDE DISMUTASE [FE] SODA |
Virulence factor |
MUTATION: sodA mutant is attenuated in mice [Ref6309:Edwards et al., 2001]. |
11751190
|
|
|
Rv3864 |
Mycobacterium tuberculosis H37Rv |
886185
|
|
15611000
|
Rv3864 |
|
NP_218381.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ethR |
Mycobacterium tuberculosis H37Rv |
886189
|
|
15610991
|
Rv3855 |
|
NP_218372.1 |
TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
PE35 |
Mycobacterium tuberculosis H37Rv |
886191
|
|
57117163
|
Rv3872 |
|
YP_178021.1 |
PE FAMILY-RELATED PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
esxB from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886194
|
|
15611010
|
Rv3874 |
|
NP_218391.1 |
10 KDA CULTURE FILTRATE ANTIGEN ESXB (LHP) (CFP10) |
Virulence factor |
MUTATION: esxB (CFP-10) mutant is attenuated in mice [Ref6298:Fortune et al., 2005]. |
16030141
|
|
|
Rv3868 |
Mycobacterium tuberculosis H37Rv |
886199
|
|
15611004
|
Rv3868 |
|
NP_218385.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3866 |
Mycobacterium tuberculosis H37Rv |
886200
|
|
15611002
|
Rv3866 |
|
NP_218383.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3866 mutant is attenuated in mice [Ref6308:Brodin et al., 2006]. |
16368961
|
|
|
PPE68 |
Mycobacterium tuberculosis H37Rv |
886201
|
|
57117164
|
Rv3873 |
|
YP_178022.1 |
PPE FAMILY PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3871 |
Mycobacterium tuberculosis H37Rv |
886202
|
|
15611007
|
Rv3871 |
|
NP_218388.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3871 mutant is attenuated in mice [Ref6310:Stanley et al., 2003]. |
14557536
|
|
|
Rv3870 |
Mycobacterium tuberculosis H37Rv |
886204
|
|
15611006
|
Rv3870 |
|
NP_218387.1 |
POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: Rv3870 mutant is attenuated in mice [Ref6310:Stanley et al., 2003]. |
14557536
|
|
|
Rv3876 |
Mycobacterium tuberculosis H37Rv |
886206
|
|
15611012
|
Rv3876 |
|
NP_218393.1 |
CONSERVED HYPOTHETICAL PROLINE AND ALANINE RICH PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3877 |
Mycobacterium tuberculosis H37Rv |
886207
|
|
15611013
|
Rv3877 |
|
NP_218394.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: Rv3877 (snm4) mutant is attenuated in mice [Ref6310:Stanley et al., 2003]. |
14557536
|
|
|
Rv3882c |
Mycobacterium tuberculosis H37Rv |
886208
|
|
15611018
|
Rv3882c |
|
NP_218399.1 |
POSSIBLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
esxA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886209
|
|
57117165
|
Rv3875 |
|
YP_178023.1 |
6 KDA EARLY SECRETORY ANTIGENIC TARGET ESXA (ESAT-6) |
Virulence factor |
MUTATION: esxA (ESAT-6) mutant is attenuated in mice [Ref6298:Fortune et al., 2005]. |
16030141
|
|
|
Rv3887c |
Mycobacterium tuberculosis H37Rv |
886211
|
|
15611023
|
Rv3887c |
|
NP_218404.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: Rv3887c mutant is attenuated in mice [Ref6311:MacGurn and Cox, 2007]. |
17353284
|
|
|
Rv3881c |
Mycobacterium tuberculosis H37Rv |
886214
|
|
15611017
|
Rv3881c |
|
NP_218398.1 |
CONSERVED HYPOTHETICAL ALANINE AND GLYCINE RICH PROTEIN |
Virulence factor |
MUTATION: Rv3881c (espB) mutant is attenuated in macrophages [Ref6312:McLaughlin et al., 2007]. |
17676952
|
|
|
mycP1 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886217
|
|
15611019
|
Rv3883c |
|
NP_218400.1 |
MEMBRANE-ANCHORED MYCOSIN MYCP1 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-1) |
Virulence factor |
MUTATION: mycP1 mutant is attenuated in chronic infection of mice [Ref6313:Ohol et al., 2010]. |
20227664
|
|
|
Rv3910 |
Mycobacterium tuberculosis H37Rv |
886247
|
|
15611046
|
Rv3910 |
|
NP_218427.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
hbhA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886272
|
|
15607616
|
Rv0475 |
|
NP_214989.1 |
IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN) |
Virulence factor |
MUTATION: hbhA mutant is attenuated in attachment and invasion of pneumocytes [Ref6314:Pethe et al., 2001]. |
11449276
|
|
|
pcaA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886284
|
|
57116736
|
Rv0470c |
|
YP_177730.1 |
MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) |
Virulence factor |
MUTATION: pcaA mutant is attenuated in mice [Ref6315:Glickman et al., 2000]. |
10882107
|
|
|
icl from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886291
|
|
57116734
|
Rv0467 |
|
YP_177728.1 |
isocitrate lyase |
Virulence factor |
MUTATION: icl mutant is attenuated in activated macrophages [Ref6316:McKinney et al., 2000]. |
10963599
|
|
|
Rv1590 |
Mycobacterium tuberculosis H37Rv |
886292
|
|
15608728
|
Rv1590 |
|
NP_216106.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
proV |
Mycobacterium tuberculosis H37Rv |
886293
|
|
15610894
|
Rv3758c |
|
NP_218275.1 |
POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
bioB |
Mycobacterium tuberculosis H37Rv |
886301
|
|
15608727
|
Rv1589 |
|
NP_216105.1 |
biotin synthase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
bioA |
Mycobacterium tuberculosis H37Rv |
886343
|
|
15608706
|
Rv1568 |
|
NP_216084.1 |
adenosylmethionine--8-amino-7-oxononanoate transaminase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
bioF1 |
Mycobacterium tuberculosis H37Rv |
886345
|
|
57116887
|
Rv1569 |
|
YP_177822.1 |
8-amino-7-oxononanoate synthase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sodC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886358
|
|
15607573
|
Rv0432 |
|
NP_214946.1 |
PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] SODC |
Virulence factor |
MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type [Ref6276:Piddington et al., 2001]. |
11447176
|
|
|
Rv1560 |
Mycobacterium tuberculosis H37Rv |
886359
|
|
15608698
|
Rv1560 |
|
NP_216076.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
xthA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886370
|
|
15607568
|
Rv0427c |
|
NP_214941.1 |
PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
thiE |
Mycobacterium tuberculosis H37Rv |
886391
|
|
15607555
|
Rv0414c |
|
NP_214928.1 |
thiamine-phosphate pyrophosphorylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
pknG from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886397
|
|
15607551
|
Rv0410c |
|
NP_214924.1 |
SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G) |
Virulence factor |
MUTATION: pknG mutant is attenuated in mice [Ref6317:Cowley et al., 2004]. |
15186418
|
|
|
lspA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886408
|
|
15608677
|
Rv1539 |
|
NP_216055.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lspA mutant is attenuated in mice [Ref6280:Rampini et al., 2008]. |
18832305
|
|
|
pks5 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886442
|
|
15608665
|
Rv1527c |
|
NP_216043.1 |
Probable polyketide synthase pks5 |
Virulence factor |
MUTATION: pks5 mutant is attenuated in mice [Ref6293:Rousseau et al., 2003]. |
12855735
|
|
|
Rv1514c |
Mycobacterium tuberculosis H37Rv |
886457
|
|
15608652
|
Rv1514c |
|
NP_216030.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0326 |
Mycobacterium tuberculosis H37Rv |
886544
|
|
15607467
|
Rv0326 |
|
NP_214840.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1465 |
Mycobacterium tuberculosis H37Rv |
886569
|
|
15608603
|
Rv1465 |
|
NP_215981.1 |
POSSIBLE NITROGEN FIXATION RELATED PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1460 |
Mycobacterium tuberculosis H37Rv |
886573
|
|
57116868
|
Rv1460 |
|
NP_215976.2 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ctpD |
Mycobacterium tuberculosis H37Rv |
886578
|
|
15608607
|
Rv1469 |
|
NP_215985.1 |
PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1422 |
Mycobacterium tuberculosis H37Rv |
886670
|
|
15608560
|
Rv1422 |
|
NP_215938.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0249c |
Mycobacterium tuberculosis H37Rv |
886671
|
|
15607390
|
Rv0249c |
|
NP_214763.1 |
PROBABLE SUCCINATE DEHYDROGENASE [MEMBRANE ANCHOR SUBUNIT] (SUCCINIC DEHYDROGENASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lprG |
Mycobacterium tuberculosis H37Rv |
886700
|
|
15608549
|
Rv1411c |
|
NP_215927.1 |
PROBABLE CONSERVED LIPOPROTEIN LPRG |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1410c |
Mycobacterium tuberculosis H37Rv |
886709
|
|
15608548
|
Rv1410c |
|
NP_215926.1 |
AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1405c |
Mycobacterium tuberculosis H37Rv |
886714
|
|
15608543
|
Rv1405c |
|
NP_215921.1 |
PUTATIVE METHYLTRANSFERASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0218 |
Mycobacterium tuberculosis H37Rv |
886727
|
|
15607359
|
Rv0218 |
|
NP_214732.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0216 |
Mycobacterium tuberculosis H37Rv |
886729
|
|
15607357
|
Rv0216 |
|
NP_214730.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0204c |
Mycobacterium tuberculosis H37Rv |
886747
|
|
15607345
|
Rv0204c |
|
NP_214718.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mmpL11 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886750
|
|
15607343
|
Rv0202c |
|
NP_214716.1 |
PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 |
Virulence factor |
MUTATION: mmpL11 mutant is attenuated in mice [Ref6318:Domenech et al., 2005]. |
15908378
|
|
|
Rv0199 |
Mycobacterium tuberculosis H37Rv |
886753
|
|
15607340
|
Rv0199 |
|
NP_214713.1 |
PROBABLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0176 |
Mycobacterium tuberculosis H37Rv |
886799
|
|
15607317
|
Rv0176 |
|
NP_214690.1 |
PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1371 |
Mycobacterium tuberculosis H37Rv |
886800
|
|
15608511
|
Rv1371 |
|
NP_215887.1 |
PROBABLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0175 |
Mycobacterium tuberculosis H37Rv |
886801
|
|
15607316
|
Rv0175 |
|
NP_214689.1 |
PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lprK |
Mycobacterium tuberculosis H37Rv |
886804
|
|
15607314
|
Rv0173 |
|
NP_214687.1 |
POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mce1C |
Mycobacterium tuberculosis H37Rv |
886808
|
|
15607312
|
Rv0171 |
|
NP_214685.1 |
MCE-FAMILY PROTEIN MCE1C |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mce1B |
Mycobacterium tuberculosis H37Rv |
886810
|
|
15607311
|
Rv0170 |
|
NP_214684.1 |
MCE-FAMILY PROTEIN MCE1B |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
yrbE1B from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886812
|
|
15607309
|
Rv0168 |
|
NP_214682.1 |
CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE1B |
Virulence factor |
MUTATION: yrbE1B mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
fadD5 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886822
|
|
15607307
|
Rv0166 |
|
NP_214680.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD5 mutant is attenuated in mice [Ref6319:Dunphy et al., 2010]. |
20214478
|
|
|
mce1A |
Mycobacterium tuberculosis H37Rv |
886823
|
|
57116701
|
Rv0169 |
|
YP_177701.1 |
MCE-FAMILY PROTEIN MCE1A |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadD33 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
886855
|
|
15608485
|
Rv1345 |
|
NP_215861.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD33 mutant is attenuated in mice [Ref6320:Rindi et al., 2002]. |
12480891
|
|
|
murI |
Mycobacterium tuberculosis H37Rv |
886866
|
|
15608478
|
Rv1338 |
|
NP_215854.1 |
glutamate racemase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1333 |
Mycobacterium tuberculosis H37Rv |
886882
|
|
15608473
|
Rv1333 |
|
NP_215849.1 |
PROBABLE HYDROLASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1332 |
Mycobacterium tuberculosis H37Rv |
886901
|
|
15608472
|
Rv1332 |
|
NP_215848.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadA4 |
Mycobacterium tuberculosis H37Rv |
886904
|
|
15608463
|
Rv1323 |
|
NP_215839.1 |
acetyl-CoA acetyltransferase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0100 |
Mycobacterium tuberculosis H37Rv |
886931
|
|
15607242
|
Rv0100 |
|
NP_214614.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadD10 |
Mycobacterium tuberculosis H37Rv |
886933
|
|
15607241
|
Rv0099 |
|
NP_214613.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0098 |
Mycobacterium tuberculosis H37Rv |
886935
|
|
15607240
|
Rv0098 |
|
NP_214612.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
atpB |
Mycobacterium tuberculosis H37Rv |
886941
|
|
15608444
|
Rv1304 |
|
NP_215820.1 |
F0F1 ATP synthase subunit A |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
nrp |
Mycobacterium tuberculosis H37Rv |
886951
|
|
15607243
|
Rv0101 |
|
NP_214615.1 |
PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) |
Virulence factor |
MUTATION attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1284 |
Mycobacterium tuberculosis H37Rv |
886987
|
|
15608424
|
Rv1284 |
|
NP_215800.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1272c |
Mycobacterium tuberculosis H37Rv |
887021
|
|
15608412
|
Rv1272c |
|
NP_215788.1 |
PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ino1 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887028
|
|
15607188
|
Rv0046c |
|
NP_214560.1 |
MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) |
Virulence factor |
MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs [Ref6321:Movahedzadeh et al., 2004]. |
14763976
|
|
|
lpqZ |
Mycobacterium tuberculosis H37Rv |
887093
|
|
15608384
|
Rv1244 |
|
NP_215760.1 |
PROBABLE LIPOPROTEIN LPQZ |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sugC |
Mycobacterium tuberculosis H37Rv |
887104
|
|
15608378
|
Rv1238 |
|
NP_215754.1 |
PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003] |
14569030
|
|
|
sugB |
Mycobacterium tuberculosis H37Rv |
887121
|
|
15608377
|
Rv1237 |
|
NP_215753.1 |
PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sugA |
Mycobacterium tuberculosis H37Rv |
887124
|
|
15608376
|
Rv1236 |
|
NP_215752.1 |
PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
tatB |
Mycobacterium tuberculosis H37Rv |
887143
|
|
15608364
|
Rv1224 |
|
NP_215740.1 |
sec-independent translocase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lpqY |
Mycobacterium tuberculosis H37Rv |
887145
|
|
15608375
|
Rv1235 |
|
NP_215751.1 |
PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
accD1 |
Mycobacterium tuberculosis H37Rv |
887168
|
|
15609639
|
Rv2502c |
|
NP_217018.1 |
PROBABLE ACETYL-/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD1 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0485 |
Mycobacterium tuberculosis H37Rv |
887170
|
|
15607626
|
Rv0485 |
|
NP_214999.1 |
POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
Virulence factor |
MUTATION: Rv0485 mutant is attenuated in mice [Ref6322:Goldstone et al., 2009]. |
19651861
|
|
|
Rv2885c |
Mycobacterium tuberculosis H37Rv |
887173
|
|
15610022
|
Rv2885c |
|
NP_217401.1 |
PROBABLE TRANSPOSASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
senX3 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887185
|
|
15607631
|
Rv0490 |
|
NP_215004.1 |
PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
regX3 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887195
|
|
15607632
|
Rv0491 |
|
NP_215005.1 |
TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
Rv3574 |
Mycobacterium tuberculosis H37Rv |
887204
|
|
15610710
|
Rv3574 |
|
NP_218091.1 |
TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ftsY |
Mycobacterium tuberculosis H37Rv |
887205
|
|
15610058
|
Rv2921c |
|
NP_217437.1 |
PROBABLE CELL DIVISION PROTEIN FTSY (SRP RECEPTOR) (SIGNAL RECOGNITION PARTICLE RECEPTOR) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
gcvT |
Mycobacterium tuberculosis H37Rv |
887233
|
|
15609348
|
Rv2211c |
|
NP_216727.1 |
glycine cleavage system aminomethyltransferase T |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3551 |
Mycobacterium tuberculosis H37Rv |
887235
|
|
15610687
|
Rv3551 |
|
NP_218068.1 |
POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
aceE |
Mycobacterium tuberculosis H37Rv |
887246
|
|
15609378
|
Rv2241 |
|
NP_216757.1 |
pyruvate dehydrogenase subunit E1 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3519 |
Mycobacterium tuberculosis H37Rv |
887247
|
|
15610655
|
Rv3519 |
|
NP_218036.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2472 |
Mycobacterium tuberculosis H37Rv |
887255
|
|
15609609
|
Rv2472 |
|
NP_216988.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
proC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887256
|
|
15607641
|
Rv0500 |
|
NP_215014.1 |
pyrroline-5-carboxylate reductase |
Virulence factor |
MUTATION: proC mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
fadA6 |
Mycobacterium tuberculosis H37Rv |
887285
|
|
15610692
|
Rv3556c |
|
NP_218073.1 |
acetyl-CoA acetyltransferase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ilvB1 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887286
|
|
57117044
|
Rv3003c |
|
YP_177917.1 |
acetolactate synthase 1 catalytic subunit |
Virulence factor |
MUTATION: ilvB1 mutant is attenuated in mice [Ref6323:Awasthy et al., 2009]. |
19542000
|
|
|
pks15 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887291
|
|
15610084
|
Rv2947c |
|
NP_217463.1 |
PROBABLE POLYKETIDE SYNTHASE PKS15 |
Virulence factor |
MUTATION: pks15 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
ppgK |
Mycobacterium tuberculosis H37Rv |
887313
|
|
15609839
|
Rv2702 |
|
NP_217218.1 |
POLYPHOSPHATE GLUCOKINASE PPGK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ung |
Mycobacterium tuberculosis H37Rv |
887410
|
|
15610113
|
Rv2976c |
|
NP_217492.1 |
uracil-DNA glycosylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadD28 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887454
|
|
15610078
|
Rv2941 |
|
NP_217457.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD28 mutant is attenuated in mice [Ref6324:Cox et al., 1999]. |
10573420
|
|
|
ceoC |
Mycobacterium tuberculosis H37Rv |
887493
|
|
57117016
|
Rv2692 |
|
YP_177901.1 |
TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mmpL7 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887548
|
|
15610079
|
Rv2942 |
|
NP_217458.1 |
CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL7 |
Virulence factor |
MUTATION: mmpL7 mutant is attenuated in mice [Ref6324:Cox et al., 1999]. |
10573420
|
|
|
Rv1204c |
Mycobacterium tuberculosis H37Rv |
887552
|
|
15608344
|
Rv1204c |
|
NP_215720.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
hspX from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887579
|
|
15609168
|
Rv2031c |
|
NP_216547.1 |
HEAT SHOCK PROTEIN HSPX (ALPHA-CRSTALLIN HOMOLOG) (14 kDa ANTIGEN) (HSP16.3) |
Virulence factor |
MUTATION: hspX mutant is attenuated in murine macrophages and THP-1 cells [Ref6325:Yuan et al., 1998]. |
9689123
|
|
|
sigD from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887594
|
|
15610550
|
Rv3414c |
|
NP_217931.1 |
RNA polymerase sigma factor SigD |
Virulence factor |
MUTATION: sigD mutant is attenuated in human macrophages and mice [Ref6273:Calamita et al., 2005]. |
15659067
|
|
|
gcp |
Mycobacterium tuberculosis H37Rv |
887595
|
|
15610555
|
Rv3419c |
|
NP_217936.1 |
O-sialoglycoprotein endopeptidase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
whiB3 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887598
|
|
15610552
|
Rv3416 |
|
NP_217933.1 |
TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB3 |
Virulence factor |
MUTATION: whiB3 mutant is attenuated in mice [Ref6326:Steyn et al., 2002]. |
11880648
|
|
|
fadD26 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887603
|
|
57117038
|
Rv2930 |
|
NP_217446.2 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD26 mutant is attenuated in mice [Ref6327:Infante et al., 2005]. |
15958066
|
|
|
fadE22 |
Mycobacterium tuberculosis H37Rv |
887617
|
|
15610198
|
Rv3061c |
|
NP_217577.1 |
PROBABLE ACYL-CoA DEHYDROGENASE FADE22 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0566c |
Mycobacterium tuberculosis H37Rv |
887633
|
|
15607706
|
Rv0566c |
|
NP_215080.1 |
nucleotide-binding protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
trpD from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887681
|
|
15609329
|
Rv2192c |
|
NP_216708.1 |
anthranilate phosphoribosyltransferase |
Virulence factor |
MUTATION: trpD mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
fabG from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887697
|
|
15610638
|
Rv3502c |
|
NP_218019.1 |
3-ketoacyl-(acyl-carrier-protein) reductase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
plsC |
Mycobacterium tuberculosis H37Rv |
887744
|
|
15609620
|
Rv2483c |
|
NP_216999.1 |
POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPH |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mce2A from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887745
|
|
57116756
|
Rv0589 |
|
YP_177740.1 |
MCE-FAMILY PROTEIN MCE2A |
Virulence factor |
MUTATION: mce2A mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
Rv2707 |
Mycobacterium tuberculosis H37Rv |
887750
|
|
15609844
|
Rv2707 |
|
NP_217223.1 |
PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
cyp125 |
Mycobacterium tuberculosis H37Rv |
887782
|
|
15610681
|
Rv3545c |
|
NP_218062.1 |
PROBABLE CYTOCHROME P450 125 CYP125 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
serB2 |
Mycobacterium tuberculosis H37Rv |
887815
|
|
15610179
|
Rv3042c |
|
NP_217558.1 |
phosphoserine phosphatase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadE32 |
Mycobacterium tuberculosis H37Rv |
887818
|
|
15610699
|
Rv3563 |
|
NP_218080.1 |
PROBABLE ACYL-CoA DEHYDROGENASE FADE32 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3588c |
Mycobacterium tuberculosis H37Rv |
887836
|
|
15610724
|
Rv3588c |
|
NP_218105.1 |
CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadE30 |
Mycobacterium tuberculosis H37Rv |
887838
|
|
15610696
|
Rv3560c |
|
NP_218077.1 |
PROBABLE ACYL-CoA DEHYDROGENASE FADE30 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2224c |
Mycobacterium tuberculosis H37Rv |
887857
|
|
15609361
|
Rv2224c |
|
NP_216740.1 |
Probable exported protease |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
relA from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
887888
|
|
15609720
|
Rv2583c |
|
NP_217099.1 |
PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE) |
Virulence factor |
MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism [Ref6284:Primm et al., 2000]. |
10940033
|
|
|
Rv2040c |
Mycobacterium tuberculosis H37Rv |
887893
|
|
15609177
|
Rv2040c |
|
NP_216556.1 |
Probable sugar-transport integral membrane protein ABC transporter |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2693c |
Mycobacterium tuberculosis H37Rv |
887917
|
|
15609830
|
Rv2693c |
|
NP_217209.1 |
PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH PROTEIN |
Virulence factor |
MUTATION: Rv2693c mutant is attenuated in mice [Ref6311:MacGurn and Cox, 2007]. |
17353284
|
|
|
Rv3400 |
Mycobacterium tuberculosis H37Rv |
887918
|
|
15610536
|
Rv3400 |
|
NP_217917.1 |
PROBABLE HYDROLASE |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lppX |
Mycobacterium tuberculosis H37Rv |
887956
|
|
15610082
|
Rv2945c |
|
NP_217461.1 |
PROBABLE CONSERVED LIPOPROTEIN LPPX |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
drrB |
Mycobacterium tuberculosis H37Rv |
887968
|
|
15610074
|
Rv2937 |
|
NP_217453.1 |
PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRB |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv1211 |
Mycobacterium tuberculosis H37Rv |
887990
|
|
15608351
|
Rv1211 |
|
NP_215727.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2038c |
Mycobacterium tuberculosis H37Rv |
887998
|
|
15609175
|
Rv2038c |
|
NP_216554.1 |
Probable sugar-transport ATP-binding protein ABC transporter |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3472 |
Mycobacterium tuberculosis H37Rv |
888006
|
|
15610608
|
Rv3472 |
|
NP_217989.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2912c |
Mycobacterium tuberculosis H37Rv |
888017
|
|
15610049
|
Rv2912c |
|
NP_217428.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3335c |
Mycobacterium tuberculosis H37Rv |
888029
|
|
15610471
|
Rv3335c |
|
NP_217852.1 |
PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv0636 |
Mycobacterium tuberculosis H37Rv |
888031
|
|
15607776
|
Rv0636 |
|
NP_215150.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3371 |
Mycobacterium tuberculosis H37Rv |
888053
|
|
15610507
|
Rv3371 |
|
NP_217888.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mmaA3 |
Mycobacterium tuberculosis H37Rv |
888058
|
|
15607783
|
Rv0643c |
|
NP_215157.1 |
METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
amiD |
Mycobacterium tuberculosis H37Rv |
888064
|
|
15610511
|
Rv3375 |
|
NP_217892.1 |
PROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3377c |
Mycobacterium tuberculosis H37Rv |
888073
|
|
15610513
|
Rv3377c |
|
NP_217894.1 |
POSSIBLE CYCLASE |
Virulence factor |
MUTATION: Rv3377c mutant is attenuated in survival inside of macrophages [Ref6290:Pethe et al., 2004]. |
15340136
|
|
|
Rv3378c |
Mycobacterium tuberculosis H37Rv |
888075
|
|
15610514
|
Rv3378c |
|
NP_217895.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3378c mutant is attenuated in survival within macrophages [Ref6290:Pethe et al., 2004]. |
15340136
|
|
|
mkl |
Mycobacterium tuberculosis H37Rv |
888081
|
|
15607795
|
Rv0655 |
|
NP_215169.1 |
POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fadE28 |
Mycobacterium tuberculosis H37Rv |
888091
|
|
15610680
|
Rv3544c |
|
NP_218061.1 |
PROBABLE ACYL-CoA DEHYDROGENASE FADE28 |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sigH from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888094
|
|
15610359
|
Rv3223c |
|
NP_217739.1 |
RNA polymerase sigma factor RpoE |
Virulence factor |
MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice [Ref6272:Kaushal et al., 2002]. |
12060776
|
|
|
Rv2206 |
Mycobacterium tuberculosis H37Rv |
888107
|
|
57116956
|
Rv2206 |
|
NP_216722.2 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: Rv2206 mutant is attenuated in mice [Ref6311:MacGurn and Cox, 2007]. |
17353284
|
|
|
pks1 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888122
|
|
15610083
|
Rv2946c |
|
NP_217462.1 |
PROBABLE POLYKETIDE SYNTHASE PKS1 |
Virulence factor |
MUTATION: pks1 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
drrA |
Mycobacterium tuberculosis H37Rv |
888168
|
|
15610073
|
Rv2936 |
|
NP_217452.1 |
PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
end |
Mycobacterium tuberculosis H37Rv |
888190
|
|
15607810
|
Rv0670 |
|
NP_215184.1 |
endonuclease IV |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
leuD from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888225
|
|
15610124
|
Rv2987c |
|
NP_217503.1 |
isopropylmalate isomerase small subunit |
Virulence factor |
MUTATION: leuD mutant is attenuated in mice [Ref6283:Hondalus et al., 2000]. |
10768986
|
|
|
Rv2553c |
Mycobacterium tuberculosis H37Rv |
888228
|
|
15609690
|
Rv2553c |
|
NP_217069.1 |
PROBABLE CONSERVED MEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ltp3 |
Mycobacterium tuberculosis H37Rv |
888247
|
|
15610659
|
Rv3523 |
|
NP_218040.1 |
acetyl-CoA acetyltransferase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
fabG from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888279
|
|
15607827
|
Rv0687 |
|
NP_215201.1 |
3-ketoacyl-(acyl-carrier-protein) reductase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3527 |
Mycobacterium tuberculosis H37Rv |
888295
|
|
15610663
|
Rv3527 |
|
NP_218044.1 |
hypothetical protein |
Virulence factor |
MUTATION: Rv3527 mutant is attenuated for intramacrophage survival [Ref6290:Pethe et al., 2004]. |
15340136
|
|
|
Rv2734 |
Mycobacterium tuberculosis H37Rv |
888303
|
|
15609871
|
Rv2734 |
|
NP_217250.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
yrbE4A |
Mycobacterium tuberculosis H37Rv |
888320
|
|
15610637
|
Rv3501c |
|
NP_218018.1 |
CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE4A |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
cobL |
Mycobacterium tuberculosis H37Rv |
888321
|
|
15609209
|
Rv2072c |
|
NP_216588.1 |
Probable precorrin-6y methyltransferase CobL |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
cobC |
Mycobacterium tuberculosis H37Rv |
888337
|
|
15609368
|
Rv2231c |
|
NP_216747.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mce4A from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888344
|
|
57117113
|
Rv3499c |
|
YP_177977.1 |
MCE-FAMILY PROTEIN MCE4A |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
pks12 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888350
|
|
15609185
|
Rv2048c |
|
NP_216564.1 |
Probable polyketide synthase pks12 |
Virulence factor |
MUTATION: pks12 mutant is attenuated in mice [Ref6328:Sirakova et al., 2003]. |
12819062
|
|
|
mce4C |
Mycobacterium tuberculosis H37Rv |
888354
|
|
15610633
|
Rv3497c |
|
NP_218014.1 |
MCE-FAMILY PROTEIN MCE4C |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2275 |
Mycobacterium tuberculosis H37Rv |
888355
|
|
15609412
|
Rv2275 |
|
NP_216791.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lprN |
Mycobacterium tuberculosis H37Rv |
888364
|
|
15610631
|
Rv3495c |
|
NP_218012.1 |
POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY LIPOPROTEIN MCE4E) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3534c |
Mycobacterium tuberculosis H37Rv |
888387
|
|
15610670
|
Rv3534c |
|
NP_218051.1 |
4-hydroxy-2-ketovalerate aldolase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3489 |
Mycobacterium tuberculosis H37Rv |
888410
|
|
15610625
|
Rv3489 |
|
NP_218006.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ddl |
Mycobacterium tuberculosis H37Rv |
888415
|
|
15610118
|
Rv2981c |
|
NP_217497.1 |
D-alanyl-alanine synthetase A |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lipF from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888430
|
|
15610623
|
Rv3487c |
|
NP_218004.1 |
PROBABLE ESTERASE/LIPASE LIPF |
Virulence factor |
MUTATION: lipF mutant is attenuated in mice lungs [Ref6329:Camacho et al., 1999]. |
10564470
|
|
|
cpsA |
Mycobacterium tuberculosis H37Rv |
888445
|
|
15610620
|
Rv3484 |
|
NP_218001.1 |
POSSIBLE CONSERVED PROTEIN CPSA |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ltp2 |
Mycobacterium tuberculosis H37Rv |
888450
|
|
15610676
|
Rv3540c |
|
NP_218057.1 |
lipid-transfer protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3541c |
Mycobacterium tuberculosis H37Rv |
888475
|
|
15610677
|
Rv3541c |
|
NP_218058.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2696c |
Mycobacterium tuberculosis H37Rv |
888482
|
|
15609833
|
Rv2696c |
|
NP_217212.1 |
CONSERVED HYPOTHETICAL ALANINE AND GLYCINE AND VALINE RICH PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3542c |
Mycobacterium tuberculosis H37Rv |
888486
|
|
15610678
|
Rv3542c |
|
NP_218059.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
drrC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888491
|
|
15610075
|
Rv2938 |
|
NP_217454.1 |
PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC |
Virulence factor |
MUTATION: drrC mutant is attenuated in mice [Ref6329:Camacho et al., 1999]. |
10564470
|
|
|
Rv2277c |
Mycobacterium tuberculosis H37Rv |
888498
|
|
15609414
|
Rv2277c |
|
NP_216793.1 |
Possible glycerolphosphodiesterase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
proS |
Mycobacterium tuberculosis H37Rv |
888539
|
|
15609982
|
Rv2845c |
|
NP_217361.1 |
prolyl-tRNA synthetase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2857c |
Mycobacterium tuberculosis H37Rv |
888560
|
|
15609994
|
Rv2857c |
|
NP_217373.1 |
short chain dehydrogenase |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2813 |
Mycobacterium tuberculosis H37Rv |
888570
|
|
15609950
|
Rv2813 |
|
NP_217329.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sigL from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888609
|
|
15607875
|
Rv0735 |
|
NP_215249.1 |
RNA polymerase sigma factor SigL |
Virulence factor |
MUTATION: sigL mutant is attenuated in mice [Ref6288:Hahn et al., 2005]. |
16199577
|
|
|
Rv2998 |
Mycobacterium tuberculosis H37Rv |
888646
|
|
15610135
|
Rv2998 |
|
NP_217514.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3087 |
Mycobacterium tuberculosis H37Rv |
888653
|
|
15610224
|
Rv3087 |
|
NP_217603.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3258c |
Mycobacterium tuberculosis H37Rv |
888694
|
|
15610394
|
Rv3258c |
|
NP_217775.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
ctpC |
Mycobacterium tuberculosis H37Rv |
888705
|
|
15610406
|
Rv3270 |
|
NP_217787.1 |
PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sigC from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888723
|
|
15609206
|
Rv2069 |
|
NP_216585.1 |
RNA polymerase sigma factor SigC |
Virulence factor |
MUTATION: sigC mutant is attenuated in mice [Ref6281:Sun et al., 2004]. |
15049808
|
|
|
sigF from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888727
|
|
15610422
|
Rv3286c |
|
NP_217803.1 |
RNA polymerase sigma factor SigF |
Virulence factor |
MUTATION: sigF mutant is attenuated in mice [Ref6269:Geiman et al., 2004]. |
14977982
|
|
|
Rv3277 |
Mycobacterium tuberculosis H37Rv |
888729
|
|
15610413
|
Rv3277 |
|
NP_217794.1 |
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
mtrA |
Mycobacterium tuberculosis H37Rv |
888743
|
|
15610382
|
Rv3246c |
|
NP_217763.1 |
TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
sigE from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888751
|
|
15608361
|
Rv1221 |
|
NP_215737.1 |
RNA polymerase sigma factor SigE |
Virulence factor |
MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type [Ref6282:Manganelli et al., 2001]. |
11489128
|
|
|
phoP from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888772
|
|
15607897
|
Rv0757 |
|
NP_215271.1 |
POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP |
Virulence factor |
MUTATION: phoP mutant is attenuated in mice [Ref6330:Pérez et al., 2001]. |
11454210
|
|
|
Rv3168 |
Mycobacterium tuberculosis H37Rv |
888778
|
|
15610304
|
Rv3168 |
|
NP_217684.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3114 |
Mycobacterium tuberculosis H37Rv |
888779
|
|
15610251
|
Rv3114 |
|
NP_217630.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3178 |
Mycobacterium tuberculosis H37Rv |
888786
|
|
15610314
|
Rv3178 |
|
NP_217694.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3103c |
Mycobacterium tuberculosis H37Rv |
888798
|
|
15610240
|
Rv3103c |
|
NP_217619.1 |
HYPOTHETICAL PROLINE-RICH PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2004c |
Mycobacterium tuberculosis H37Rv |
888817
|
|
15609141
|
Rv2004c |
|
NP_216520.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3229c |
Mycobacterium tuberculosis H37Rv |
888821
|
|
57117078
|
Rv3229c |
|
YP_177948.1 |
POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
devR from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888842
|
|
15610269
|
Rv3133c |
|
NP_217649.1 |
TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY) |
Virulence factor |
MUTATION: devR mutant is attenuated in guinea pigs [Ref6331:Malhotra et al., 2004]. |
14987770
|
|
|
Rv3236c |
Mycobacterium tuberculosis H37Rv |
888861
|
|
57117079
|
Rv3236c |
|
YP_177949.1 |
PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv3050c |
Mycobacterium tuberculosis H37Rv |
888866
|
|
15610187
|
Rv3050c |
|
NP_217566.1 |
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY) |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
moeB1 from Mycobacterium tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
888871
|
|
57117072
|
Rv3206c |
|
YP_177942.1 |
molybdopterin biosynthesis-like protein MoeZ |
Virulence factor |
MUTATION: moeB1 mutant is attenuated in mice [Ref6311:MacGurn and Cox, 2007]. |
17353284
|
|
|
Rv3210c |
Mycobacterium tuberculosis H37Rv |
888876
|
|
15610346
|
Rv3210c |
|
NP_217726.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
Rv2808 |
Mycobacterium tuberculosis H37Rv |
888944
|
|
15609945
|
Rv2808 |
|
NP_217324.1 |
hypothetical protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6292:Sassetti and Rubin, 2003]. |
14569030
|
|
|
lspA from Mycobacterium tuberculosis F11 |
Mycobacterium tuberculosis F11 |
5222252
|
|
148822762
|
TBFG_11572 |
|
YP_001287517.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lspA mutant is attenuated in mice [Ref6280:Rampini et al., 2008]. |
18832305
|
|
|
trpD from Mycobacterium tuberculosis F11 |
Mycobacterium tuberculosis F11 |
5222896
|
|
148823399
|
TBFG_12220 |
|
YP_001288153.1 |
anthranilate phosphoribosyltransferase |
Virulence factor |
MUTATION: trpD mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
leuD from Mycobacterium tuberculosis F11 |
Mycobacterium tuberculosis F11 |
5223688
|
|
148824177
|
TBFG_13002 |
|
YP_001288931.1 |
isopropylmalate isomerase small subunit |
Virulence factor |
MUTATION: leuD mutant is attenuated in mice [Ref6283:Hondalus et al., 2000]. |
10768986
|
|
|
panC from Mycobacterium tuberculosis F11 |
Mycobacterium tuberculosis F11 |
5224323
|
|
148824807
|
TBFG_13634 |
|
YP_001289561.1 |
pantoate--beta-alanine ligase |
Virulence factor |
MUTATION: pan CD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
mgtC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211668
|
|
148661617
|
MRA_1823 |
|
YP_001283140.1 |
Mg2+ transport P-type ATPase C |
Virulence factor |
MUTATION: mgtC mutant is attenuated in human macrophages and mice [Ref6277:Buchmeier et al., 2000]. |
10760138
|
|
|
hspR from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211729
|
|
148660119
|
MRA_0362 |
|
YP_001281642.1 |
heat shock protein transcriptional repressor HspR |
Virulence factor |
MUTATION: hspR mutant is attenuated in mice [Ref6274:Stewart et al., 2001]. |
11385512
|
|
|
sigD from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211733
|
|
148663278
|
MRA_3454 |
|
YP_001284801.1 |
RNA polymerase sigma factor SigD |
Virulence factor |
MUTATION: sigD mutant is attenuated in human macrophages and mice [Ref6273:Calamita et al., 2005]. |
15659067
|
|
|
whiB3 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211735
|
|
148663280
|
MRA_3456 |
|
YP_001284803.1 |
transcriptional regulatory protein whib-like WhiB3 |
Virulence factor |
MUTATION: whiB3 mutant is attenuated in mice [Ref6326:Steyn et al., 2002]. |
11880648
|
|
|
mce2A from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211750
|
|
148660358
|
MRA_0596 |
|
YP_001281881.1 |
MCE-family protein Mce2A |
Virulence factor |
MUTATION: mce2A mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
hbhA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211814
|
|
148660242
|
MRA_0482 |
|
YP_001281765.1 |
iron-regulated heparin binding hemagglutinin Hbha |
Virulence factor |
MUTATION: hbhA mutant is attenuated in attachment and invasion of pneumocytes [Ref6314:Pethe et al., 2001]. |
11449276
|
|
|
pks12 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211927
|
|
148661862
|
MRA_2063 |
|
YP_001283385.1 |
polyketide synthase Pks12 |
Virulence factor |
MUTATION: pks12 mutant is attenuated in mice [Ref6328:Sirakova et al., 2003]. |
12819062
|
|
|
mce3A from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5211946
|
|
148661775
|
MRA_1977 |
|
YP_001283298.1 |
MCE-family protein Mce3A |
Virulence factor |
MUTATION: mce3A mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
fadD5 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212238
|
|
148659930
|
MRA_0174 |
|
YP_001281453.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD5 mutant is attenuated in mice [Ref6319:Dunphy et al., 2010]. |
20214478
|
|
|
sigL from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212242
|
|
148660510
|
MRA_0743 |
|
YP_001282033.1 |
RNA polymerase sigma factor SigL |
Virulence factor |
MUTATION: sigL mutant is attenuated in mice [Ref6288:Hahn et al., 2005]. |
16199577
|
|
|
mmpL11 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212263
|
|
148659966
|
MRA_0210 |
|
YP_001281489.1 |
membrane protein MmpL11 |
Virulence factor |
MUTATION: mmpL11 mutant is attenuated in mice [Ref6318:Domenech et al., 2005]. |
15908378
|
|
|
senX3 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212269
|
|
148660257
|
MRA_0497 |
|
YP_001281780.1 |
putative two component sensor histidine kinase SenX3 |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
regX3 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212270
|
|
148660258
|
MRA_0498 |
|
YP_001281781.1 |
two component sensory transduction protein RegX3 |
Virulence factor |
MUTATION: senX3-regX3 deletion mutant is attenuated in mice [Ref6278:Parish et al., 2003]. |
12777483
|
|
|
plcC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212285
|
|
148662177
|
MRA_2369 |
|
YP_001283700.1 |
phospholipase C 3 PlcC |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
plcB from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212286
|
|
148662178
|
MRA_2370 |
|
YP_001283701.1 |
membrane-associated phospholipase C 2 |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
plcA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212287
|
|
148662179
|
MRA_2371 |
|
YP_001283702.1 |
membrane-associated phospholipase C 1 |
Virulence factor |
MUTATION: plcABC triple mutants are attenuated in mice [Ref6305:Raynaud et al., 2002]. |
12100560
|
|
|
devR from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212298
|
|
148662987
|
MRA_3165 |
|
YP_001284510.1 |
two component transcriptional regulatory protein DevR |
Virulence factor |
MUTATION: devR mutant is attenuated in guinea pigs [Ref6331:Malhotra et al., 2004]. |
14987770
|
|
|
hspX from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212340
|
|
148661845
|
MRA_2046 |
|
YP_001283368.1 |
antigen Hsp20 |
Virulence factor |
MUTATION: hspX mutant is attenuated in murine macrophages and THP-1 cells [Ref6325:Yuan et al., 1998]. |
9689123
|
|
|
fadD26 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212516
|
|
148662776
|
MRA_2956 |
|
YP_001284299.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD26 mutant is attenuated in mice [Ref6327:Infante et al., 2005]. |
15958066
|
|
|
sigC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212564
|
|
148661883
|
MRA_2083 |
|
YP_001283406.1 |
RNA polymerase sigma factor SigC |
Virulence factor |
MUTATION: sigC mutant is attenuated in mice [Ref6281:Sun et al., 2004]. |
15049808
|
|
|
mprA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212587
|
|
148660762
|
MRA_0988 |
|
YP_001282285.1 |
mycobacterial persistence regulator MrpA |
Virulence factor |
MUTATION: mprA mutant is attenuated in mice [Ref6291:Zahrt and Deretic, 2001]. |
11675502
|
|
|
pepD from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212589
|
|
148660764
|
MRA_0990 |
|
YP_001282287.1 |
serine protease PepD |
Virulence factor |
MUTATION: pepD mutant has altered virulence in mouse model of infection [Ref6299:White et al., 2010]. |
20061478
|
|
|
ino1 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212676
|
|
148659806
|
MRA_0049 |
|
YP_001281329.1 |
1L-myo-inositol-1-phosphate synthase |
Virulence factor |
MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs [Ref6321:Movahedzadeh et al., 2004]. |
14763976
|
|
|
trpD from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212696
|
|
148662009
|
MRA_2208 |
|
YP_001283532.1 |
anthranilate phosphoribosyltransferase |
Virulence factor |
MUTATION: trpD mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
lipF from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212740
|
|
148663351
|
MRA_3527 |
|
YP_001284874.1 |
esterase LipF |
Virulence factor |
MUTATION: lipF mutant is attenuated in mice lungs [Ref6329:Camacho et al., 1999]. |
10564470
|
|
|
pks1 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212915
|
|
148662793
|
MRA_2973 |
|
YP_001284316.1 |
putative polyketide synthase Pks1 |
Virulence factor |
MUTATION: pks1 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
pks15 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5212916
|
|
148662794
|
MRA_2974 |
|
YP_001284317.1 |
polyketide synthase Pks15 |
Virulence factor |
MUTATION: pks15 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
cysH from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213172
|
|
148662225
|
MRA_2416 |
|
YP_001283748.1 |
phosphoadenosine phosphosulfate reductase |
Virulence factor |
MUTATION: cysH mutant is attenuated in mice [Ref6286:Senaratne et al., 2006]. |
16553880
|
|
|
secA2 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213460
|
|
148661627
|
MRA_1833 |
|
YP_001283150.1 |
preprotein translocase subunit SecA |
Virulence factor |
MUTATION: secA2 mutant is attenuated in mice [Ref6301:Braunstein et al., 2003]. |
12675804
|
|
|
relA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213487
|
|
148662422
|
MRA_2612 |
|
YP_001283945.1 |
GTP pyrophosphokinase RelA |
Virulence factor |
MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism [Ref6284:Primm et al., 2000]. |
10940033
|
|
|
drrC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213524
|
|
148662784
|
MRA_2964 |
|
YP_001284307.1 |
daunorubicin-dim ABC transporter permease protein DrrC |
Virulence factor |
MUTATION: drrC mutant is attenuated in mice [Ref6329:Camacho et al., 1999]. |
10564470
|
|
|
fadD28 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213527
|
|
148662787
|
MRA_2967 |
|
YP_001284310.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD28 mutant is attenuated in mice [Ref6324:Cox et al., 1999]. |
10573420
|
|
|
mmpL7 |
Mycobacterium tuberculosis H37Ra |
5213528
|
|
148662788
|
MRA_2968 |
|
YP_001284311.1 |
transmembrane transport protein MmpL7 |
Virulence factor |
MUTATION: mmpL7 mutant is attenuated in mice [Ref6324:Cox et al., 1999]. |
10573420
|
|
|
sodC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213568
|
|
148660197
|
MRA_0437 |
|
YP_001281720.1 |
superoxide dismutase |
Virulence factor |
MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type [Ref6276:Piddington et al., 2001]. |
11447176
|
|
|
pks5 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213745
|
|
148661323
|
MRA_1539 |
|
YP_001282846.1 |
putative polyketide synthase pks5 |
Virulence factor |
MUTATION: pks5 mutant is attenuated in mice [Ref6293:Rousseau et al., 2003]. |
12855735
|
|
|
sodA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5213873
|
|
148663714
|
MRA_3886 |
|
YP_001285237.1 |
superoxide dismutase |
Virulence factor |
MUTATION: sodA mutant is attenuated in mice [Ref6309:Edwards et al., 2001]. |
11751190
|
|
|
mbtB from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214000
|
|
148662215
|
MRA_2406 |
|
YP_001283738.1 |
dihydroaeruginoic acid synthetase |
Virulence factor |
MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells [Ref6303:De et al., 2000]. |
10655517
|
|
|
leuD from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214120
|
|
148662837
|
MRA_3016 |
|
YP_001284360.1 |
isopropylmalate isomerase small subunit |
Virulence factor |
MUTATION: leuD mutant is attenuated in mice [Ref6283:Hondalus et al., 2000]. |
10768986
|
|
|
sigH from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214150
|
|
148663085
|
MRA_3263 |
|
YP_001284608.1 |
RNA polymerase sigma factor RpoE |
Virulence factor |
MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice [Ref6272:Kaushal et al., 2002]. |
12060776
|
|
|
proC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214181
|
|
148660268
|
MRA_0507 |
|
YP_001281791.1 |
pyrroline-5-carboxylate reductase |
Virulence factor |
MUTATION: proC mutant is attenuated in mice [Ref6279:Smith et al., 2001]. |
11160012
|
|
|
pknG from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214250
|
|
148660175
|
MRA_0416 |
|
YP_001281698.1 |
serine/threonine protein kinase |
Virulence factor |
MUTATION: pknG mutant is attenuated in mice [Ref6317:Cowley et al., 2004].
|
15186418
|
|
|
prrA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214363
|
|
148660681
|
MRA_0910 |
|
YP_001282204.1 |
two component response transcriptional regulatory protein PrrA |
Virulence factor |
MUTATION: prrA mutant is attenuated in murine macrophages [Ref6295:Ewann et al., 2002]. |
11953357
|
|
|
katG from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214412
|
|
148661716
|
MRA_1919 |
|
YP_001283239.1 |
catalase-peroxidase |
Virulence factor |
MUTATION: katG mutant is attenuated in mice and guinea pigs [Ref6275:Li et al., 1998]. |
9534978
|
|
|
esxB from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214548
|
|
148663741
|
MRA_3913 |
|
YP_001285264.1 |
antigen EsxB |
Virulence factor |
MUTATION: esxB (CFP-10) mutant is attenuated in mice [Ref6298:Fortune et al., 2005]. |
16030141
|
|
|
esxA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214549
|
|
148663742
|
MRA_3914 |
|
YP_001285265.1 |
early secretory antigenic target EsxA |
Virulence factor |
MUTATION: esxA (ESAT-6) mutant is attenuated in mice [Ref6298:Fortune et al., 2005]. |
16030141
|
|
|
mycP1 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214557
|
|
148663750
|
MRA_3922 |
|
YP_001285273.1 |
membrane-anchored mycosin Mycp1 |
Virulence factor |
MUTATION: mycP1 is attenuated in chronic infection of mice [Ref6313:Ohol et al., 2010]. |
20227664
|
|
|
fbpA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214567
|
|
148663672
|
MRA_3844 |
|
YP_001285195.1 |
secreted antigen 85-A FbpA |
Virulence factor |
MUTATION: fbpA mutant is attenuated in mice [Ref6270:Copenhaver et al., 2004]. |
15557632
|
|
|
ahpC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214581
|
|
148662263
|
MRA_2455 |
|
YP_001283786.1 |
AhpC |
Virulence factor |
MUTATION: ahpC mutant has decreased survival in unactivated macrophages compared to the wild type [Ref6285:Master et al., 2002]. |
12368447
|
|
|
panD from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214616
|
|
148663465
|
MRA_3640 |
|
YP_001284988.1 |
aspartate alpha-decarboxylase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
panC from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214617
|
|
148663466
|
MRA_3641 |
|
YP_001284989.1 |
pantoate--beta-alanine ligase |
Virulence factor |
MUTATION: panCD mutant is attenuated in mice [Ref6271:Sambandamurthy et al., 2002]. |
12219086
|
|
|
ompA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214708
|
|
148660677
|
MRA_0906 |
|
YP_001282200.1 |
outer membrane protein A |
Virulence factor |
MUTATION: ompA mutant is impaired in its ability to grow in macrophages and in normal mice, although it was as virulent as the wild type in mice that lack T cells [Ref6296:Raynaud et al., 2002]. |
12366842
|
|
|
lspA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214891
|
|
148661335
|
MRA_1551 |
|
YP_001282858.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lspA mutant is attenuated in mice [Ref6280:Rampini et al., 2008]. |
18832305
|
|
|
mmpL8 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5214944
|
|
148663691
|
MRA_3863 |
|
YP_001285214.1 |
transmembrane transport protein MmpL8 |
Virulence factor |
MUTATION: mmpL8 mutant is attenuated in mice [Ref6307:Converse et al., 2003]. |
12724526
|
|
|
yrbE1B from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215107
|
|
148659932
|
MRA_0176 |
|
YP_001281455.1 |
conserved hypothetical integral membrane protein YrbE1b |
Virulence factor |
MUTATION: yrbE1B mutant is attenuated in mice [Ref6304:Gioffré et al., 2005]. |
15804490
|
|
|
phoP from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215306
|
|
148660534
|
MRA_0767 |
|
YP_001282057.1 |
putative two component system response transcriptional positive regulator PhoP |
Virulence factor |
MUTATION: phoP mutant is attenuated in mice [Ref6330:Pérez et al., 2001]. |
11454210
|
|
|
ilvB1 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215324
|
|
148662854
|
MRA_3033 |
|
YP_001284377.1 |
acetolactate synthase 1 catalytic subunit |
Virulence factor |
MUTATION: ilvB1 mutant is attenuated in mice [Ref6323:Awasthy et al., 2009]. |
19542000
|
|
|
sigE from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215382
|
|
148661008
|
MRA_1230 |
|
YP_001282531.1 |
RNA polymerase sigma factor SigE |
Virulence factor |
MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type [Ref6282:Manganelli et al., 2001]. |
11489128
|
|
|
pks10 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215526
|
|
148661456
|
MRA_1671 |
|
YP_001282979.1 |
putative chalcone synthase Pks10 |
Virulence factor |
MUTATION: pks10 mutant is attenuated in mice [Ref6294:Sirakova et al., 2003]. |
12730158
|
|
|
pks7 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215527
|
|
148661457
|
MRA_1672 |
|
YP_001282980.1 |
putative polyketide synthase Pks7 |
Virulence factor |
MUTATION: pks7 mutant is attenuated in mice [Ref6293:Rousseau et al., 2003]. |
12855735
|
|
|
moeB1 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215558
|
|
148663066
|
MRA_3244 |
|
YP_001284589.1 |
molybdopterin biosynthesis-like protein MoeZ |
Virulence factor |
MUTATION: moeB1 mutant is attenuated in mice [Ref6311:MacGurn and Cox, 2007]. |
17353284
|
|
|
icl from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215578
|
|
148660233
|
MRA_0473 |
|
YP_001281756.1 |
isocitrate lyase Icl |
Virulence factor |
MUTATION: icl mutant is attenuated in activated macrophages [Ref6316:McKinney et al., 2000]. |
10963599
|
|
|
pcaA from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215613
|
|
148660236
|
MRA_0476 |
|
YP_001281759.1 |
mycolic acid synthase PcaA |
Virulence factor |
MUTATION: pcaA mutant is attenuated in mice [Ref6315:Glickman et al., 2000]. |
10882107
|
|
|
fadD33 from Mycobacterium tuberculosis H37Ra |
Mycobacterium tuberculosis H37Ra |
5215636
|
|
148661134
|
MRA_1353 |
|
YP_001282657.1 |
acyl-CoA synthetase |
Virulence factor |
MUTATION: fadD33 mutant is attenuated in mice [Ref6320:Rindi et al., 2002]. |
12480891
|
|
|
lysA |
Mycobacterium tuberculosis H37Rv |
886960
|
|
15608433
|
Rv1293 |
BX842576 |
NP_215809 |
diaminopimelate decarboxylase LysA |
Virulence factor |
MUTATION: lysA mutant is markedly attenuated in SCID mice, and is strongly attenuated in mice when in combination with a secA2 mutation [Ref7342:Hinchey et al., 2011]. |
21264335
|
|
|
mce-2 |
Mycobacterium tuberculosis CDC1551 |
925014
|
|
15839991
|
MT0618 |
AE000516 |
NP_335028 |
virulence factor |
Virulence factor |
MUTATION: a mce-2 mutant is a strongly attenuated in BALB/c mice [Ref7343:Aguilar et al., 2006]. |
16388878
|
|
|
mce-3 |
Mycobacterium tuberculosis CDC1551 |
923491
|
|
15841441
|
MT2018 |
AE000516 |
NP_336478 |
virulence factor |
Virulence factor |
MUTATION: mce-3 mutant is strongly attenuated in BALB/c mice [Ref7343:Aguilar et al., 2006]. |
16388878
|
