Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

plcB from Mycobacterium tuberculosis H37Rv

Victor ID 135
Gene Name plcB from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885999
NCBI Protein GI 15609487
Locus Tag Rv2350c
Protein Accession NP_216866.1
Other Database IDs UniProtKB-ID: PHLB_MYCTU
UniRef100: UniRef100_P95246
UniRef90: UniRef90_P95246
UniRef50: UniRef50_P95246
UniParc: UPI0000131977
EMBL: U49511
EMBL: BX842579
EMBL: AE000516
EMBL-CDS: AAC18944.1
EMBL-CDS: CAB06147.1
EMBL-CDS: AAK46708.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000000881
EnsemblGenome_TRS: EBMYCT00000000881
EnsemblGenome_PRO: EBMYCP00000000881
EnsemblGenome: EBMYCG00000069282
EnsemblGenome_TRS: EBMYCT00000069287
EnsemblGenome_PRO: EBMYCP00000067346
Genome
Taxonomy ID 83332
Gene Starting Position 2628780
Gene Ending Position 2630318
Gene Strand (Orientation) -
Protein Name PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB
DNA Sequence 
>gi|57116681:2628780-2630318 Mycobacterium tuberculosis H37Rv, complete genome
GTCAACAGAGACCGCTGGGAATCCCCCGAGTGGGTGCGGTTTCTTGGGTGGGCATCGACTGTGGGAATGG
CACCCGATAGGGAATTGCCGTCTTGGTCACCGTTCCCAGTACTGCGTTGGGCACGCACTGCGGCAACTTC
GGAAGCGCATTGAGCCGCGGGTGGTCCAGATTGGGTTTCGACGGGTTCGGCGGAGCGGCGAAGTTGAACG
TCGAAGTCATATCGCCGACCGTCGCGTCCCGCCAAGCGGTGAGATTGGGAACCGGGACGCCGAACCGCGC
GCGGATGAGCTTCAGCGTTGACGTGTGATCGAAGGTGTCGTGGACCATCAGTGGGCCGCGGCTATAGGGA
GAGATGACGAGGCAAGGGACGCGAAACCCCAGACCGATCGGCCCACGAATGCCACCCGAGCCGGGCACCG
AGTCGATGTCGGGGACCGTGACGAATTCGCCGGGCGTCCCCGGCGGCGGTGTCGGCGGCACGACGTGGTC
GAAGAACCCGCCGTTCTCGTCGTAGTTGACGATCAGCGCGGTCTTTTCCCACACCGCAGGGTTGGACAGC
AAGATCCGCAGTGCATCGACAATTGCAACGGCGCCGACGTTCACCGGGAATGCGGGATGTTCGGACAGCA
GAAACCCGGGCAGCACCCAGGAGACCTTGGGTAATCGGTTGTTTCTGACGTCGGCGGCGAAGTCCAGCGG
GTAGGTCGGTGAGATGCCGAAACGGGCCAGATTCGACCTCGGATCCGCGGCCTGCTTGAAGTCATTGACC
AGCCCGTTGTAGCCGACGACGGTGTTGTTGAGAGCCCCCAGCAATTTGTTTTGGTACACCTTCCAGCTGA
CCCCGGCATCTTCGAGGTTCTCCGGCATGATGCGCCAGCTGTAGTGCTGCAGAGGTTGGATATTGGGCTC
GATCAGCACCGGCCCGCCGTCAGTGCCGTCGGGGTCGATCCAGGCGCTCATCCAGTAGAGCCGGTTGGGC
GTGGTCCCGCCCAGCAGCGAGCAAAAATAGCCGTCGCAGACCGTGAACGTGTCGGCTAGCAGGTAGTGAA
TGGGCAGGTCACGACGCGTGTAGAAACCCATCGTGACCGGCACGTTGCCCTGCAACGGACTGAACGGGAC
CTGCGCCGGCAGCCAGTTGTCGTTGGCGCCGCCGTTCCACGAGTTGTGCATGCCGATCCAGCTGTGGTCC
GGGTCGTTGACGCATTCGCCGGCGACCAGCGGGCCCCGGGTGGTGTCGAAGCGATATGGAAGGGTGACGC
CGGCGGGGTCAACCGCCTGTGTCATCGGGTTCCAGCCCGACTGCGCGAATACCACCGGCGGGGTGGTGTC
ATCGAACCCGCGGGTGTCAGAAAGAGTGCCGAAGTAGTGATCGAATGACCGATTCTCCTGCATCAACAAC
ACGATGTGCTCGATGTCGGTCAAATGTCCGGGGCAAGGCCCCGCTCCGTAGGCTTTTTCGATAATCGGAC
CAGCCAAGGACATGAAGGCCCCGGCGGTGGTAGCGGCGGCGGCTTTGGCAAAAAATTGTCGGCGGGTCA
Protein Sequence 
>gi|15609487|ref|NP_216866.1| membrane-associated phospholipase B [Mycobacterium tuberculosis H37Rv] MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQAVDPAGVTLPYRFDTTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQVPFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFCSLLGGTTPNRLYWMSAWIDPDGTDGGPVLIEPNIQPLQHYSWRIMPENLEDAGVSWKVYQNKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYPLDFAADVRNNRLPKVSWVLPGFLLSEHPAFPVNVGAVAIVDALRILLSNPAVWEKTALIVNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLGFRVPCLVISPYSRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDATVGDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQCVPNAVLGTVTKTAIPYRVPFPQSMPTQETAPTRGIPSGLC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002).
COG COG3511M, under M: Cell wall/membrane/envelope biogenesis
References
Raynaud et al., 2002: Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelicic V, Manganelli R, Smith I, Gicquel B, Jackson M. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Molecular microbiology. 2002; 45(1); 203-217. [PubMed: 12100560].