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sigE from Mycobacterium tuberculosis H37Rv

Victor ID 333
Gene Name sigE from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888751
Uniprot ID L7N676
NCBI Protein GI 15608361
Locus Tag Rv1221
Protein Accession NP_215737.1
Other Database IDs UniProtKB-ID: O06289_MYCTU
UniRef100: UniRef100_A1KI09
UniRef90: UniRef90_A1KI09
UniRef50: UniRef50_A0QCH1
UniParc: UPI000004B71F
EMBL: U87242
EMBL: AE000516
EMBL: BX842575
EMBL-CDS: AAC45268.1
EMBL-CDS: AAK45516.1
EMBL-CDS: CAB10918.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
HSSP: P34086
EnsemblGenome: EBMYCG00000003588.
EnsemblGenome_TRS: EBMYCT00000003590
EnsemblGenome_PRO: EBMYCP00000003590
EnsemblGenome: EBMYCG00000072498.
EnsemblGenome_TRS: EBMYCT00000072503
EnsemblGenome_PRO: EBMYCP0
Taxonomy ID 83332
Gene Starting Position 1364412
Gene Ending Position 1365185
Gene Strand (Orientation) +
Protein Name RNA polymerase sigma factor SigE
DNA Sequence 
>gi|57116681:1364412-1365185 Mycobacterium tuberculosis H37Rv, complete genome
CATGGAACTCCTCGGCGGACCCCGGGTTGGGAATACGGAATCGCAACTTTGCGTTGCCGACGGTGACGAC
TTGCCAACTTATTGCAGTGCAAATTCGGAGGATCTCAATATCACGACCATCACGACCTTGAGTCCGACCA
GCATGTCTCATCCCCAACAGGTCCGCGATGACCAGTGGGTGGAGCCGTCTGACCAATTGCAGGGCACCGC
CGTATTCGACGCCACCGGGGACAAGGCCACCATGCCGTCCTGGGATGAGCTGGTCCGTCAGCACGCCGAT
CGGGTGTACCGGCTGGCTTATCGGCTCTCCGGCAACCAGCACGATGCCGAAGACCTGACCCAGGAGACCT
TTATCAGGGTGTTCCGGTCGGTCCAGAATTACCAGCCGGGCACCTTCGAAGGCTGGCTACACCGCATCAC
CACCAACTTGTTCCTGGACATGGTCCGCCGCCGGGCTCGCATCCGGATGGAGGCGTTACCCGAGGACTAC
GACCGGGTGCCCGCCGATGAGCCCAACCCCGAGCAGATCTACCACGACGCACGGCTGGGACCTGACCTGC
AGGCTGCCTTGGCCTCGCTGCCGCCGGAGTTTCGTGCCGCGGTGGTGCTGTGTGACATCGAGGGTCTGTC
GTACGAGGAGATCGGCGCCACACTGGGCGTGAAGCTCGGGACGGTACGTAGCCGGATACACCGCGGACGC
CAGGCACTGCGGGACTACCTGGCAGCGCACCCCGAACATGGCGAGTGCGCAGTTCACGTCAACCCAGTTC
GCTG
Protein Sequence 
>gi|15608361|ref|NP_215737.1| ECF RNA polymerase sigma factor SigE [Mycobacterium tuberculosis H37Rv] MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type (Manganelli et al., 2001).
Predicted Interacting Host Protein A8MY43; B7Z207; B7Z7N6; D6RDN9; E9PCY5; E9PD65; F8W8L1; G3V384; G3V3E0; G3V419; H3BUV3; J3KTB7; O14874; P07900; P08238; P11388; Q02880; Q14568; Q15118; Q15119;
Q15120; Q16654; Q58FF6; Q9UHC1
COG COG1595K, under K: Transcription
References
Manganelli et al., 2001: Manganelli R, Voskuil MI, Schoolnik GK, Smith I. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Molecular microbiology. 2001; 41(2); 423-437. [PubMed: 11489128].