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ino1 from Mycobacterium tuberculosis H37Rv

Victor ID 225
Gene Name ino1 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887028
NCBI Protein GI 15607188
Locus Tag Rv0046c
Protein Accession NP_214560.1
Other Database IDs UniProtKB-ID: INO1_MYCTU
UniRef100: UniRef100_P71703
UniRef90: UniRef90_P71703
UniRef50: UniRef50_A0R7G6
UniParc: UPI00001119C3
EMBL: BX842572
EMBL: AE000516
EMBL-CDS: CAB02525.1
EMBL-CDS: AAK44274.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 1GR0
EnsemblGenome: EBMYCG00000002545
EnsemblGenome_TRS: EBMYCT00000002547
EnsemblGenome_PRO: EBMYCP00000002547
EnsemblGenome: EBMYCG00000069380
EnsemblGenome_TRS: EBMYCT00000069385
EnsemblGenome_PRO: EBMYCP00000067444
GenomeReviews: AE000516_GR
Gen
Taxonomy ID 83332
Gene Starting Position 50020
Gene Ending Position 51123
Gene Strand (Orientation) -
Protein Name MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase)
DNA Sequence 
>gi|57116681:50020-51123 Mycobacterium tuberculosis H37Rv, complete genome
GCTAACCGATGATGAACTCTTCGAGTTGCGCGCGCGCGATGTCGTCGGGCAGCTGCTCGGGCGGGCTCTT
CATCAGGTAGGCCGACGCCGGGATCACCGGTCCGCCGATGCCGCGGTCCTTGGCGATCTTGGCCGCCCGC
ACCGCGTCGATGATGACGCCGGCCGAGTTTGGCGAGTCCCACACCTCGAGCTTGTACTCCAGGTTCAACG
GCACATCTCCGAAGGCGCGGCCCTCAAGACGGACATAGGCCCATTTGCGATCGTCGAGCCATCCGACGTG
GTCGGACGGGCCGATGTGCACGTCCTTGGTCTTGAACTCGCGCTTCAGATTCGAAGTGACGGCCTGGGTC
TTGGAGATCTTCTTGGACTCCAGCCGTTCACGTTCGAGCATGTTGAGGAAGTCCATGTTGCCGCCCACGT
TGAGCTGCATGGTGCGGTCGAGCTGCACGCCGCGGTCCTCGAACAGCTTGGCCAGCACCCGGTGGGTGAT
CGTCGCGCCGACCTGGCTCTTGATGTCATCACCGACGATGGGTACCCTGGCGTCGGTGAACTTCTTGGCC
CACACCGGGTCGGAGGCGATGAACACCGGCAGCGCGTTGACGAACGCCACCCCGGCGTCGATAGCACACT
GGGCGTAGAACTTGTCGGCTTCCTCCGAGCCCACCGGCAAATAGGAGACCAGCACGTCGACCTTGGCCTC
CTTGAGCGCCTGGACGACGTCGACGGGCTCCGCGTCGGAGAGTTCGATGGTGTCGGCGTAGTACTTGCCG
ATGCCATCGAGGGTAGGCCCGCGCTGCACGATCACGTTGGTCGGCGCCACATCGGCGATCTTGATGGTGT
TGTTCTCCGAGGCGAAGATGGCGTCGGACAGGTCGAAGCCGACCTTCTTGGCGTCCACGTCGAACGCCGC
CACGAACTTGACGTCGCGAACGTGGTACGGGCCGAACCGCACGTGCATGAGGCCCGGTACGGTCGATGTG
TCGTCGGCGTTGTAGTAGTACTCGACGCCCTGGACCAGCGAGGACGCGCAGTTGCCGACGCCGACAATGG
CGACTCGAACCTCCGTCGACGCCTCCGGCGCCGGTAACGACTGGTGCTCACTCA
Protein Sequence 
>gi|15607188|ref|NP_214560.1| inositol-3-phosphate synthase [Mycobacterium tuberculosis H37Rv] MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs (Movahedzadeh et al., 2004).
COG COG1260I, under I: Lipid transport and metabolism
References
Movahedzadeh et al., 2004: Movahedzadeh F, Smith DA, Norman RA, Dinadayala P, Murray-Rust J, Russell DG, Kendall SL, Rison SC, McAlister MS, Bancroft GJ, McDonald NQ, Daffe M, Av-Gay Y, Stoker NG. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Molecular microbiology. 2004; 51(4); 1003-1014. [PubMed: 14763976].