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pks7 from Mycobacterium tuberculosis H37Ra

Victor ID 1903
Gene Name pks7 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215527
NCBI Protein GI 148661457
Locus Tag MRA_1672
Protein Accession YP_001282980.1
Other Database IDs UniProtKB-ID: A5U318_MYCTA
UniRef100: UniRef100_A5WMY3
UniRef90: UniRef90_A5WMY3
UniRef50: UniRef50_A0PQM7
UniParc: UPI00000D6039
EMBL: CP000611
EMBL-CDS: ABQ73418.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067574.
EnsemblGenome_TRS: EBMYCT00000067579
EnsemblGenome_PRO: EBMYCP00000065689
GenomeReviews: CP000611_GR
KEGG: mra:MRA_1672
eggNOG: COG3321
HOGENOM: HBG669988
OMA: ACRLIDV
ProtClustDB: CLSK791302
BioCyc: MTUB419947:MRA_1672-MONOMER
Taxonomy ID 419947
Gene Starting Position 1876821
Gene Ending Position 1883201
Gene Strand (Orientation) +
Protein Name putative polyketide synthase Pks7
DNA Sequence 
>gi|148659757:1876821-1883201 Mycobacterium tuberculosis H37Ra, complete genome
CATGAACAGCACTCCCGAAGACCTCGTCAAGGCCCTGCGCAGATCGCTCAAGCAAAACGAGCGACTGAAG
CGAGAGAACCGGGATCTTCTTGCCCGGACCACCGAGCCGGTGGCGGTGGTGGGGATGGGATGCCGCTATC
CGGGTGGGGTGGATTCGCCGGAGACGCTGTGGGAGCTGGTGGCACACGGCCGTGACGCGGTTTCGGAGTT
CCCGGCGGATCGCGGCTGGGATGTGGCGGGGTTGTTTGACCCCGATCCCGACGCGGTAGGCAAGTCGTAT
ACCCGGTGCGGCGGGTTCTTGACGGATGTCGCCGGTTTTGACGCCGAGTTTTTCGGGATCGCACCCAGCG
AGGCGCTTGCGATGGATCCCCAGCAGCGGTTGCTGTTGGAAGTGTCGTGGGAAGCGTTGGAGCGGGCGGG
CATCGACCCAATCACGTTGCGGGGTTCGCAGACGGGCGTGTTCGCCGGGGTGTTCCACGGCTCGTATGGG
GGCCAAGGCCGGGTGCCGGGTGACCTGGAGCGCTACGGGCTGCGTGGCTCGACGCTGAGCGTGGCCTCCG
GGCGGGTGGCGTATGTGTTGGGCCTGCAGGGCCCGGCGGTGTCGGTGGATACCGCGTGTTCGTCGTCGTT
GGTGGCACTGCATTTGGCGGTGCAGTCACTGCGCCTCGGCGAATGCGACCTGGCGCTGGTCGGTGGGGTC
ACCGTGATGGCCACCCCGGCGATGTTCATCGAGTTCAGCAGGCAGCGGGCGCTGTCCGCCGATGGTCGTT
GTAAGGCCTATGCGGGTGCCGCCGATGGGACCGCGTTTGCCGAGGGCGCCGGGGTGCTCGTGCTGGCGCG
GTTGGCTGACGCGCGCCGGTTGGGGCATCCGGTGCTGGCGCTGGTGCGCGGATCGGCGGTCAATCAGGAC
GGCGCCTCCAACGGGCTGGCCACGCCGAATGGGCCGGCGCAGCAACGGGTGATCACTGCGGCGCTGGCCA
GTGCGCGGTTAGGTGTCGCCGACGTGGATGTGGTCGAGGGGCACGGGACGGGCACCACGTTGGGGGATCC
CATTGAGGCGCAGGCGATTTTGGCGACGTATGGACAGCGGCCGGCCGATCGGCCGTTGTGGCTGGGGTCG
ATCAAATCGAACATCGGTCATACGTCGGCGGCTGCGGGGGTCGCCGGGGTGATCAAGATGGTGCAGGCGA
TGCGCCACGGCGTGCTGCCCAAGACGTTGCACGTGGATGTGCCGACGCCGCATGTGGATTGGTCGGCGGG
GGCGGTGTCGTTGTTGACCGAGCCGCGGCCGTGGCACGTGCCGGGCCGGCCGCGGCGGGCCGGTGTGTCG
TCGTTCGGGATCAGCGGCACCAACGCACATGTGATTCTGGAAGAGGCACCGGCAGTGGAACCGGTTGGCG
CGGCCCATGGCAACGACCCGGTGGCGGTGCCGTGGGTGCTGTCGGCGAGGTCGGCGCAAGCGTTGACCAA
CCAGGCGCGACGGCTGTTGGCCTGGGTGGGCGCCGATGAGAACGTGCGCCCGCTCGATGTGGGGTGGTCG
CTGGTCAACACCCGGTCGCTGTTTGATCATCGGGCCGTGGTCGTGGGCGCCGACCGCACTCAGCTGATGG
AAGGGCTGACGGGTCTGGCGGCCGGCGTGCCCGGCGCCGACGTGGTGGCGGGCCGCGCCCAGACGGTGGG
CAAGACGGCATTCGTGTTCCCGGGCCAGGGCGCGCAGTGGCTGGGCATGGGAGCCCAGTTATGTGCTACC
GCACCGGTGTTCGCCGAACATATCCATCGCTGCGAACGGGCGCTGCGTGAGCACGTGGAGTGGTCGCTGC
TCGACGTGCTGCGCGGGGCACCCGGCGCACCGGGGCTGGATCGGGTGGATGTGGTGCAGCCGGCGTTGTG
GGCGGTGATGGTGTCGCTGGCCGAATTGTGGCGGTCGGTGGGTGTGGTTCCCGACGCGGTCATCGGGCAT
TCGCAGGGGGAGATCGCGGCGGCATATGTGGCGGGCGCCCTGTCGCTTCGGGACGCGGCTGCGGTGGTGG
CACTGCGCAGCCGGTTGCTGGTGCGGTTGGGCGGTGCCGGCGGCATGGTCTCGTTGGCCTGTGGCCAGCC
GCAGGCCGAGAAGTTGGCGTCCCAATGGGGAGACCGACTGAATATCGCTGCAGTCAATGGTGTCTCGTCG
GTCGTGCTGGCCGGCGAGACGGATGCCGTGACGGAGCTGATGCAGCGATGTGAGGCCGAAGGCATTCGTG
CCCGCAGGATCGACGTCGACTACGCGTCACACTCGGCGCAGGTGGACGCGATCCGGGAGGAGCTCATCGC
GGCGCTGCGAGGTATCGAACCCCGTACTTCCACGGTGGCGTTCTTCTCCACTGTCACCGGCGAACTCATG
GATACCGCCGGTGTGAACGCCGAGTACTGGTACCGAAGCATCCGCCAGCCGGTGCAGTTCGAACGCGCCG
TCCGCAACGCCTTCGACGGCGGATACCGGGTGTTCGTCGAATCCAGCCCCCATCCGGTCCTGATCGCCGG
CATCGAAGAGACGTTGGTCGACTGTGATCGCGGCGCTACGGGTGAACCGATTGTCATTCCGACGCTGGGT
CGCGATGACGGCGGGGTGGGCCGGTTTTGGCTGTCGGCGGGGCAGGCCCACGTTGCGGGCGTGGGTGTTG
ACTGGCGTGCCGCGTTTGCCGACCTGGGAGGCCGCCGGGTGGAGTTGCCGACGTACGCGTTTGCGCGCCA
GCGGTTCTGGCTAGACGGCCTAGGTGCTGTTGGCGGCGATCTGGGTGGTGTCGGCTTGGTGGGCGCCGAG
CATGGATTGTTGGCTGCAGTGGTGCAACGGCCCGACTCGGGTGGGGTGGTGTTGACGGGCCGGATATCGG
TGGTCGCTGCGCCGTGGCTGGCCGATCATGCGGTGGGCCCGGTGGTGCTGTTCCCGGGCACGGGGTTTGT
TGAGTTGGCCTTGCGGGCCGGTGACGAGGTGGGTTGTTCGGTGCTGCAGGAGTTGACGTTGCAGGCACCG
TTGGTGCTGCCGGCAGATGGGGTGCGGGTCCAGGTGGTGGTGGGCGGCGTCGAGCAGTCGGGTACTCGGA
ATGTGTGGGTGTATTCGGCTGCCGGCCAGGCGGATTCGAGTCCGGGATGGACGTTGCACGCGCAGGGCGT
GTTGGGGGTTGGCTCGGTGCAGCCGGCCGCGGAGCTGTCGGTGTGGCCGCCGGTTGGGGCACGGGCGATG
GACGTCGCCGACGGGTATCAGGTGTTGGCGGCGCGGGGGTATGGGTATGGGCCGGCGTTTCGGGGTTTGC
AGGCCTTGTGGCGGCGGGGGGCCGAGGTGTTCGCCGACGTCACTCTCCCTGAGGGTGTGCCGATACGGGG
GTTTGGGATTCATCCGGCGGTGTTGGATGCGGCGTTGCATGCGTGGGGAATTGTCGAGGGTGAGCAGCAG
ACGATGTTGCCGTTCTCGTGGCAGGGGGTGTGTTTGCACGCAAGCGGGGCTGCGCGGGTCCGTGTGCGAC
TGGCGCCGGTGGGCCGGGGGGCGGTGTCGGTGGAGTTGGCCGATCCGCAGGGGTTGCCGGTGTTGTCGGT
GCGGCAGTTGATGGTTCGTCCGGTCTCAGCGGCCGCGTTGTCGAGGTCGACCGCCGGCGACCGGGGATTG
CTGGAGATGATCTGGACACCGGTGCCGTTGGAGGGCGGCGACATTGGCGACGACGCCGTGGTGTGGGAGC
TGCCGCCTCACGCCGGCGCGCAGGCCGGCGGGGATGTGCTGGCAGCGGTGTACCGGGGTGTGCACGAGGT
GTTGGAGGTGTTGCAGTCGTGGTTGGCTAGCGATGCGACCGGTCTGGGTGTGGTGGTGACGCGTGGGGCG
GTGGGTCCGGTTGATGACGATGTCACCGATTTGGCGGGTGCTGCGGTGTGGGGGTTGGTGCGCTCTGCCC
AGGCTGAACATCCGGGCCGGGTGGTGTTGGTGGATACCGATGGGTCGGTCGCTGTCGAGGATGCGGTTGG
TTTCGGCGCACGCTCGGGTGAGCCGCAGCTGGTGGTTCGTCGAGGCCGGGTATATGCGGCACGGTTGGCC
CCGGTAGCGGCCGGGTTGACTTTGCCTTCGGCGTCGGCTGGGGGCTGGCGGTTGGTTGCCGGTGGTGGGG
GGACTTTGGCGGATGTGGTGGTGGCGCCCGTTGCTCCGGTGGAGCTGGCGACGGGGCAGGTGCGGGTGGC
CGTGGGTGCGGTGGGGGTCAATTTCCGGGATGTGTTGGTGGCGTTGGGGATGTATCCCGGCGGCGGGGAA
CTGGGTGTCGACGGGGCAGGGGTGGTCGTTGAAGTCGGCCCGGGGGTAACCGGTTTGGCCGTTGGTGACC
GGGTGATGGGGTTATTGGGGCTGGTGGGTTCGGAGGCGGTGGTGGATGCGCGGTTGGTAACCATGGTGCC
GGCGGGCTGGTCGTTGGTGGAGGCAGCGGCCGTGCCGGTGGCGTTTCTGACGGCGTTTTACGGGCTGTCG
GTGTTGGCGGAGGTCGCGGCGGGGCAGAAGGTGTTGGTGCATGCCGGCACCGGCGGGGTTGGTATGGCAG
CGGTGTCGTTGGCGCGGTATTGGGGTGCAGAGGTTTTCGTCACGGCGAGTCGCGCCAAGTGGGATACATT
GCGGGCGATGGGTTTTGACGATATCCATATCTCCGACTCGCGATCGTTGGAGTTCGAGGAGGCGTTTCTG
CGGGCCACCGAGGGCAGCGGTGTGGACGTAGTGCTGAACTCGCTCGCCGGTGAGTTCACCGATGCCTCGC
TGCGGCTACTGCCCAGCGGTGGCCGCTTTATCGAGCTGGGTAAAACCGATATTCGCGACGGGCAGACGGT
GGCCGAGCGGCATCGGGGGGTGCGGTATCGGGCGTTCGATTTGGTCGAAGCCGGCCCAGACCGCATTGCG
GCGATGCTTTCCGAGGTAGTGGGGTTGCTAGCGGCCGGAGTGTTGGCGCGGTTGCCGGTCAAGACTTTTG
ATGCGCGATGCGCCCCGGCGGCCTACCGGTTTGTCAGTCAGGCCCGTCATATCGGCAAGGTCGTGTTGAC
CATCCCCGATGGTCCGGGTGGGCAGTCCGGGTTGGCGGGGGGCACCGTGGTGGTCACTGGGGGGACCGGC
ATGGCCGGTTCGGCGGTGGCTACCCATTTGGTCCGGCGACATGGGGTGGCCAATCTGGTTCTGGTCAGCC
GAAGCGGTGAGCAGGCCGACAGGGCGGCAGAAGTCGCGGCCCTGTTGCGCGAGGGCGGGGCCCAGGTGGC
GGTGGTCTCCTGTGATGTGGCTGATCGTGATGCGCTGGCGGCATTGTTGGCGGGTCTGGATCCGCGCTAT
CCGCTTAAAGGGGTGTTTCATGCCGCTGGGGTGTTGGACGATGCCGTGATCACGGGCTTGACACCGGATC
GGGTGGATACGGTGTTGCGGGCCAAGGTCGATGGGGCCTGGAATCTGCACGAGCTAACCGAGGACATGGA
TTTGTCGGCGTTTGTGGTGTTTTCGTCGATGGCCGGGATTGTGGGCACACCGGCTCAGGGGAATTATGCT
GCGGCGAATGCGTTTTTGGACGGGTTGGTGGCCTATCGGCGCTCGCGTGGGCTGGCCGGATTGTCGGTGG
CGTGGGGACTGTGGGAGCAGGCCTCGGCGATGACCCGGCACCTCGGCGAGCGGGATCGCGCCAGGATGAC
GCAGGCCGGGCTCGCTCCGCTAACCACCGAGCAGGCGCTAGGGTTCCTGGACACTGCGCTGCAGGCCGAT
CGCGCGGTGGTAGTGGCGGCCCGGCTGGATCGTGCCGCGCTGGCCGGCGCTGGTGCTGCGCTACCGGCAT
TATTCAGCCAGTTGGCTGCCGGTCCGACCCGGCGGAGGATCGACGCCGCCGATACGGCGGTGTCGATGTC
GGGCTTAGTCAGCCGGCTGCATGCGCTCACGCCCGAGCGGCGGCAGCGCGAACTCACCGATTTGGTGATC
AGCAATGCCGCGGCGGTGTTGGGTCGTTCCAGCAGTGTCGATATCAACGCTCACAAAGCATTCCAAGATC
TCGGGTTCGATTCCTTGACCGCCGTGGAGCTGCGCAACCGACTCAAGACCGCCACCGGGCTCACGTTGTC
GCCCACGCTGATCTTCGACTACCCCACGCCGGCCACGCTGGCCGAACACCTCGACAGCCGGCTAGTCACC
GCCAGCGGTAGCGATCAACAAAGCCTGTCAGACCGTGTTGACGACATCACCCGCGAGCTAGTTGTGCTGC
TTGACCAACCCGACTTGAGCGCCAACGTCAAAGCGCACCTGCGCACCCGCCTGCAAACCATGTTGACCAG
CCTGACCACTGAAGACGACGACATCGCCGCCGCGACCGAAAGCCAGCTTTTCGCCATCCTCGACGAGGAA
CTCGGCTCCTA
Protein Sequence 
>gi|148661457|ref|YP_001282980.1| polyketide synthase Pks7 [Mycobacterium tuberculosis H37Ra] MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks7 mutant is attenuated in mice (Rousseau et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Rousseau et al., 2003: Rousseau C, Sirakova TD, Dubey VS, Bordat Y, Kolattukudy PE, Gicquel B, Jackson M. Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis. Microbiology (Reading, England). 2003; 149(Pt 7); 1837-1847. [PubMed: 12855735].