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pepD from Mycobacterium tuberculosis H37Rv

Victor ID 101
Gene Name pepD from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885382
NCBI Protein GI 15608123
Locus Tag Rv0983
Protein Accession NP_215498.1
Other Database IDs UniProtKB-ID: O53896_MYCTU
UniRef100: UniRef100_A5U125
UniRef90: UniRef90_A5WL05
UniRef50: UniRef50_A4T6T7
UniParc: UPI0000031992
EMBL: BX842575
EMBL-CDS: CAA17582.1
RefSeq_NT: NC_000962.2
PDB: 1Y8T
PDB: 2Z9I
MEROPS: S01.494
EnsemblGenome: EBMYCG00000000115.
EnsemblGenome_TRS: EBMYCT00000000115
EnsemblGenome_PRO: EBMYCP00000000115
GenomeReviews: AL123456_GR
KEGG: mtu:Rv0983
TubercuList: Rv0983
HOGENOM: HBG585708
OMA: TGPGPIP
ProtClustDB: CLSK790871
Taxonomy ID 83332
Gene Starting Position 1099065
Gene Ending Position 1100459
Gene Strand (Orientation) +
Protein Name PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B)
DNA Sequence 
>gi|57116681:1099065-1100459 Mycobacterium tuberculosis H37Rv, complete genome
CATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGGAAGAGCAACCTAGCGACATGACGAATCACCCA
CGGTATTCGCCACCGCCGCAGCAGCCGGGAACCCCAGGTTATGCTCAGGGGCAGCAGCAAACGTACAGCC
AGCAGTTCGACTGGCGTTACCCACCGTCCCCGCCCCCGCAGCCAACCCAGTACCGTCAACCCTACGAGGC
GTTGGGTGGTACCCGGCCGGGTCTGATACCTGGCGTGATTCCGACCATGACGCCCCCTCCTGGGATGGTT
CGCCAACGCCCTCGTGCAGGCATGTTGGCCATCGGCGCGGTGACGATAGCGGTGGTGTCCGCCGGCATCG
GCGGCGCGGCCGCATCCCTGGTCGGGTTCAACCGGGCACCCGCCGGCCCCAGCGGCGGCCCAGTGGCTGC
CAGCGCGGCGCCAAGCATCCCCGCAGCAAACATGCCGCCGGGGTCGGTCGAACAGGTGGCGGCCAAGGTG
GTGCCCAGTGTCGTCATGTTGGAAACCGATCTGGGCCGCCAGTCGGAGGAGGGCTCCGGCATCATTCTGT
CTGCCGAGGGGCTGATCTTGACCAACAACCACGTGATCGCGGCGGCCGCCAAGCCTCCCCTGGGCAGTCC
GCCGCCGAAAACGACGGTAACCTTCTCTGACGGGCGGACCGCACCCTTCACGGTGGTGGGGGCTGACCCC
ACCAGTGATATCGCCGTCGTCCGTGTTCAGGGCGTCTCCGGGCTCACCCCGATCTCCCTGGGTTCCTCCT
CGGACCTGAGGGTCGGTCAGCCGGTGCTGGCGATCGGGTCGCCGCTCGGTTTGGAGGGCACCGTGACCAC
GGGGATCGTCAGCGCTCTCAACCGTCCAGTGTCGACGACCGGCGAGGCCGGCAACCAGAACACCGTGCTG
GACGCCATTCAGACCGACGCCGCGATCAACCCCGGTAACTCCGGGGGCGCGCTGGTGAACATGAACGCTC
AACTCGTCGGAGTCAACTCGGCCATTGCCACGCTGGGCGCGGACTCAGCCGATGCGCAGAGCGGCTCGAT
CGGTCTCGGTTTTGCGATTCCAGTCGACCAGGCCAAGCGCATCGCCGACGAGTTGATCAGCACCGGCAAG
GCGTCACATGCCTCCCTGGGTGTGCAGGTGACCAATGACAAAGACACCCTGGGCGCCAAGATCGTCGAAG
TAGTGGCCGGTGGTGCTGCCGCGAACGCTGGAGTGCCGAAGGGCGTCGTTGTCACCAAGGTCGACGACCG
CCCGATCAACAGCGCGGACGCGTTGGTTGCCGCCGTGCGGTCCAAAGCGCCGGGCGCCACGGTGGCGCTA
ACCTTTCAGGATCCCTCGGGCGGTAGCCGCACAGTGCAAGTCACCCTCGGCAAGGCGGAGCAGTG
Protein Sequence 
>gi|15608123|ref|NP_215498.1| serine protease PepD [Mycobacterium tuberculosis H37Rv] MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pepD mutant has altered virulence in mouse model of infection (White et al., 2010).
COG COG0265O, under O: Posttranslational modification, protein turnover, chaperones
References
White et al., 2010: White MJ, He H, Penoske RM, Twining SS, Zahrt TC. PepD participates in the mycobacterial stress response mediated through MprAB and SigE. Journal of bacteriology. 2010; 192(6); 1498-1510. [PubMed: 20061478].