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relA from Mycobacterium tuberculosis H37Ra

Victor ID 1874
Gene Name relA from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5213487
NCBI Protein GI 148662422
Locus Tag MRA_2612
Protein Accession YP_001283945.1
Other Database IDs UniProtKB-ID: A5U5T3_MYCTA
UniRef100: UniRef100_P66015
UniRef90: UniRef90_P66015
UniRef50: UniRef50_O85709
UniParc: UPI000013365C
EMBL: CP000611
EMBL-CDS: ABQ74383.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065922.
EnsemblGenome_TRS: EBMYCT00000065927
EnsemblGenome_PRO: EBMYCP00000064037
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2612
eggNOG: COG0317
HOGENOM: HBG594146
OMA: WLNIVKT
ProtClustDB: CLSK791939
BioCyc: MTUB419947:MRA_2612-MONOMER
Taxonomy ID 419947
Gene Starting Position 2919793
Gene Ending Position 2922165
Gene Strand (Orientation) -
Protein Name GTP pyrophosphokinase RelA
DNA Sequence 
>gi|148659757:2919793-2922165 Mycobacterium tuberculosis H37Ra, complete genome
GCTACGCGGCCGAGGTCACCCGGTAGACGTCGTAGACACCTTCGACGTTGCGGACGGCGTTGAGCAGGTG
CCCGAGGTGCTTGGGGTCACCCATCTCGAAGGTGAATCGACTGATCGCCACCCGGTCCCCCGAAGTGGTG
ACCGACGCGGACAGGATATTGACCTTCTCGTCGGCCAGTGCGCGCGTCACATCCGACAGCAGCCGGTGCC
GGTCGAGTGCCTCGACCTGGATTGCCACCAGAAACACCGACGACGGCGACGGCGCCCATAGCACCTCGAT
GATGCGCTCGGCCTGCTGCTGCAGCGATGCGGCGTTGGTGCAGTCGGTGCGGTGCACACTGACCCCGCCG
CCACGGGTGACGAACCCCATAATCACATCGCCCGGAACCGGCGTGCAGCACTTGGCCAGCTTGGTCAGCA
CGCCCGGGGCGCCGGGGACGGAGACCCCGACATCGTCGGTGCTGCGTGGGCGCCGCGGCATGGTCGCCGG
CGTGGACCGCTCGGCGAGTTCCTCTTCCGCCTGGTCGATACCGCCGAGCTCGGCCAACAACCGCTGCACG
ACGTGTTTCGCCGACACGTGCCCCTCACCGATGGCGGTATAGAGTGCTGACACGTCCGCGTAGTGCAGCT
CGCGGGCCACCGCCGCCATGGACTCACCATTGACCAAGCGCTGCAACGGAAGTCCACCGCGGCGCACCTC
GCGGGCCATCGCATCCTTACCGGTCTCCAACGCCTCCTCACGCCGCTCCTTGGCGAACCACTGGCGGATC
TTCGTCTTTGCGCGCGGCGACACCACGAACTGCTGCCAGTCCCGCGACGGCCCGGCGTTCGGCGCCTTGG
ACGTGAAAACCTCGACAACTTCTCCGTTTTCCAGCTTGCGTTCCAGCGCTACCAACCGGCCGTTCACTCG
GGCGCCGATGCAGCGGTGGCCCACCTCTGTGTGCACCGCGTAAGCGAAGTCCACCGGCGTCGAACCGGTT
GGCAGCGTGATCACGTCGCCCTTGGGGGTAAACACGAAAATCTCTTGCACCGCAAGGTCGTAGCGCAATG
ATTCCAAGAACTCACCGGGGTCGGCCGCCTCACGTTGCCAGTCGAGCAGCTGACGCATCCAGGCCATGTC
GTCGATCTCCGCGGCGGCATGCGGATGAAGAACACCGTTGCGGCCCTTGGCTTCTTTGTAGCGCCAATGC
GCGGCGATGCCGTATTCGGCGGTGCGGTGCATGTCGCGGGTACGGATCTGCACTTCCAGCGGCTTGCCCT
CAGGCCCGACCACAGTGGTGTGCAGTGACTGGTACACACCGTATCTGGGCTGGGCGATGTAGTCCTTGAA
CCGACCCGCCATCGGCTGCCATAGCGAATGCACTACGCCGACAGCCGCGTAGCAGTCCCGGATTTCGTCG
CACAGGATGCGCACACCGACCAGGTCGTGGATGTCGTCGAAGTCGCGGCCCTTAACGATCATCTTCTGGT
AGATCGACCAATAGTGCTTGGGGCGGCCCTCCACCGTCGCCTTGATCTTCGACGCGGTCAGCGTGTTGAC
GATTTCGGCACGCACCTTGGCCAGGTAGGTGTCCCGGGACGGCGCGCGACCGGCGACCAGCCGGACGATC
TCCTCGTACTTCTTGGGATGCAGGATCGCGAAGGACAGGTCCTCCAACTCCCACTTGACGCTGGCCATGC
CCAGCCGATGCGCCAGGGGTGCAATGACTTCCAACGTCTCACGGGCCTTGCGGGCCTGCTTCTCCGGCGG
CAAGAAGCGCATGGTGCGCATGTTGTGTAACCGGTCAGCCACCTTTATCACCAGCACCCGCGGATCGCGG
GCCATCGCGGTGATCATCTTGCGAATAGTCTCGCCTTCGGCGGCGCTGCCCAACACCACCCGATCCAGCT
TGGTCACCCCGTCGACGAGATGGCCCACCTCTTCGCCGAATTCCTCGGTCAACGCCTCCAGGGTGTAACC
GGTGTCCTCGACGGTGTCGTGCAGCAGCGCGGCCACCAAAGTGGTGGTGTCCATGCCCAACTCGGCCAGA
ATGTTGGCAACGGCCAACGGGTGGGTGATGTAGGGATCACCGGACTGCCGCAACTGGCTGGCATGCCTTT
GGTCAGCGACCTCGTAGGCTCGCTGCAAGATCGACAGGTCGGCCTTGGGATAGATCTCCCGGTGCACCGC
CACCAACGGCTCGAGCACCGGATTGGTGGTGCTGCGCTGGGCGGTCATCCGCCGGGCCAATCGGGCCCGC
ACCCGACGCGACGCGCTGATGCTGGTCTTAAGAGTCTCGACCGGCGACTCGGGCGTCTCGAGAGCGGGCT
CGAGAGCCGCAGAAGCCTCCGTGGGCGGTGCAACCGCTTGCGCCGTGAGCTGGTCCTCGGCCA
Protein Sequence 
>gi|148662422|ref|YP_001283945.1| GTP pyrophosphokinase [Mycobacterium tuberculosis H37Ra] MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism (Primm et al., 2000).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Primm et al., 2000: Primm TP, Andersen SJ, Mizrahi V, Avarbock D, Rubin H, Barry CE 3rd. The stringent response of Mycobacterium tuberculosis is required for long-term survival. Journal of bacteriology. 2000; 182(17); 4889-4898. [PubMed: 10940033].