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pknG from Mycobacterium tuberculosis H37Rv

Victor ID 186
Gene Name pknG from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886397
NCBI Protein GI 15607551
Locus Tag Rv0410c
Protein Accession NP_214924.1
Other Database IDs UniProtKB-ID: PKNG_MYCTU
UniRef100: UniRef100_P65729
UniRef90: UniRef90_P65729
UniRef50: UniRef50_P65729
UniParc: UPI0000131B7D
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAB06580.1
EMBL-CDS: AAK44647.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 2PZI
EnsemblGenome: EBMYCG00000001019
EnsemblGenome_TRS: EBMYCT00000001019
EnsemblGenome_PRO: EBMYCP00000001019
EnsemblGenome: EBMYCG00000072183
EnsemblGenome_TRS: EBMYCT00000072188
EnsemblGenome_PRO: EBMYCP00000070247
GenomeReviews: AE000516_GR
Gen
Taxonomy ID 83332
Gene Starting Position 495061
Gene Ending Position 497313
Gene Strand (Orientation) -
Protein Name SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G)
DNA Sequence 
>gi|57116681:495061-497313 Mycobacterium tuberculosis H37Rv, complete genome
CTTAGAACGTGCTGGTGGGCCGGACCTTGTTGGCCATGTCCACCAGCGTGTAGCGATGCCGTTGAGTGGG
AGCTACCCGGGCCAGGCTGCGCAGTGACGCCTCGACACCCAGCCGCAGCCCGTGACTGGTGAACGGGAAA
CCGAGGATGTGGTTGGTGCTGGCCTTGTTGTCCTTCAGCCAGTCCAGCGCGCCACCCAGCACCAGGGCGC
GGATCTGCAGCACGCGTGGTTCGGTCGGGGGCAGCGCCTCCACTCTTCGGGCGGCGTCGCGGATCTGTTC
CTCGGTGACTTCACTCGTTGACCGGCCGGACAACAGAGTCACCGCGCTGGTCAGCCGTGCCGTGGTGAAA
TGCCGAGAAGTGGGCGGTACCTCGTCGAGCGTGCGCACGGCGCCGACCCGATCACCTTCGGCCGACCGGG
CTCTGGCCAGTCCGAAAGCCGCCGAGATCACGCCGTCGTTGGTGCTCCACACCGTCTGATAGAACTTGTG
TTCGTCGGTGTTGCCGGCTAGTTCGGCGGTGGCGGCCAGGGCGAGCTTGGGCGCCAGCTCGCCGGGAAAG
GTATCCAGCACCTCGGTGAAATGTTTGGTGGCCGAGTCATAGTCGCCGGTGAGCAGCTCGGCGACGGCCC
GGTACCAGACCAATCGCCATCGCCAGCCAACGCGTTCGGCCAGATCGTCGAGTTTTCGGGTGGCCTTGGC
CACATCGCCGAGATCCAGCAGCGCGCGGACTTCCATTAGCGGCAGCTCCACTGACTCGGAGAAGTCGACG
CCGTCGGCGTCCAGCGCACCGTGGCGGGCCGCGCGCAGCGAGTCTAGGGTCTGCACCGGCTGGGAGAGCA
CCGTGGCCTGCAGGACCGAAGCTGCGACGTCGGTCGGATCGACCAGCGGCACCGACAGCGCGGTCACGAT
CTCGTTGGCGGTCAGCTTCTCCGCGTGCACCTGCCCGTCCAGATACACGTCGGTGTGCGCCACCAGCAGG
TCCACTCCAAATGTCGACCGACTGGGACTGAAGATCGTTGATAGCCCTGGCCGCGGCACCCCGGTGTCCT
GGGCGACCACCTCCCGCAACACGCCCGTCAATTGCGCGGACATCTCTTCGGCGGTGGTGAACCGTTGCCG
CGGATCGGGGTCGATGGCCCTGCGCAGCAACCGGCCGTAAGAGTCGTAGGTTTTCAGCACCGGGTCGTCT
TCGGGTAGCCCATCCACATAACGGCCATTGCGGGTGGGCAGGTCCAGCGTGAGCGCCGCGAGCGTGCGTC
CCACGGTGTAGATGTCGGTGGCCACCGTCGGACCGGTCCGCACGATCTCGGGCGCCTGGAAGCCTGGGGT
CCCGTAGAGGTAGCCGAACGAGTTGATCCGCGATACCGCGCCCAGGTCGATCAGCTTGAGCTGTTCCTCG
GTCAGCATGATGTTTTCCGGCTTCAGGTCGTTGTAGACCAAGCCGATGGAATGCAGGTAGCTCAGCGCCG
GCAGGATCTCCAGCAGGTAGGCGATGGCCTCCGCGACGGGCAGTTTCTGACCCTTGCTGCGTTTGAGCGA
TTGCCCGCCGACGTATTCCATCACGATGTAGCCGACCGGATCCCCGTGCCTGTCGGTGTGCTCGACAAAG
TTGAAGATCTGCACGATCGACGGGTGCACCACCTCGGCCAGGAACTGGCGTTCGGCCATCGCCATTGCCT
GCGCTTCGGCATCACCGGAATGCACCAGGCCCTTGAGCACCACCGGACGGCCGTTGACATTGCGGTCGAG
AGCGAGGTAGATCCAGCCCAGTCCGCCGTGCGCGATGCAGCCTTTGACCTCGTACTGGCCGGCGACGATG
TCCCCGGGATTTAGCTGCGGCAGGAACGAATACGGGCTGCCGCAATAGGGACACCAGCCCTCTGAAGCTC
CCTTGGTCTCCGAGTCGGACCGGCCGACGGGACGTCCACAGTTCCAGCAGAACCGCTTGGACTCCGGCAC
CACCGGGTTGGTCATCAGGGCCTCAAGCGGATCGATATCGGGCGCCCGCGGGATTTCCACCAGGCCGCCG
CCCAGCCGTCTGACCGGCGGGCGCACCCGGCTGGTGGTGGCCATCCGGTCTTGCGGCTCGGTGTCCGGGC
CGAGCGTCGGATGGGGGAAGTTGTCCTCATCGCCGAAATCGGGGCGGAACACCGCCTGGGTGCTCAGGGG
TCGAACCGTCGCGGACGTCGCGGTCTGGGCGTCCGCCGGTTGGGTGCCGGGGCCCGAACGTTCGGTCTCT
GACGCTTTGGCCA
Protein Sequence 
>gi|15607551|ref|NP_214924.1| serine/threonine-protein kinase PknG [Mycobacterium tuberculosis H37Rv] MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pknG mutant is attenuated in mice (Cowley et al., 2004).
COG COG0515RTKL, under R: General function prediction only; T: Signal transduction mechanisms; K: Transcription; L: Replication, recombination and repair
References
Cowley et al., 2004: Cowley S, Ko M, Pick N, Chow R, Downing KJ, Gordhan BG, Betts JC, Mizrahi V, Smith DA, Stokes RW, Av-Gay Y. The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Molecular microbiology. 2004; 52(6); 1691-1702. [PubMed: 15186418].