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mprA from Mycobacterium tuberculosis H37Ra

Victor ID 1865
Gene Name mprA from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212587
NCBI Protein GI 148660762
Locus Tag MRA_0988
Protein Accession YP_001282285.1
Other Database IDs UniProtKB-ID: MPRA_MYCTA
UniRef100: UniRef100_A5U123
UniRef90: UniRef90_A0PWB4
UniRef50: UniRef50_A0PWB4
UniParc: UPI00000D5F28
EMBL: CP000611
EMBL-CDS: ABQ72723.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067126
EnsemblGenome_TRS: EBMYCT00000067131
EnsemblGenome_PRO: EBMYCP00000065241
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0988
eggNOG: COG0745
HOGENOM: HBG753323
OMA: EFSLLEM
ProtClustDB: CLSK790869
BioCyc: MTUB419947:MRA_0988-MONOMER
Taxonomy ID 419947
Gene Starting Position 1098123
Gene Ending Position 1098815
Gene Strand (Orientation) +
Protein Name mycobacterial persistence regulator MrpA
DNA Sequence 
>gi|148659757:1098123-1098815 Mycobacterium tuberculosis H37Ra, complete genome
GGTGTCCGTGCGAATTCTTGTCGTTGACGACGATCGTGCGGTGCGCGAGTCGCTGCGCCGGTCGCTTTCC
TTCAATGGCTATTCGGTCGAACTGGCCCACGACGGGGTTGAGGCGCTCGACATGATTGCCAGCGATCGCC
CCGACGCGTTGGTCCTGGATGTCATGATGCCGCGGCTGGACGGCCTCGAGGTGTGCCGTCAGCTCCGCGG
CACCGGCGACGACCTGCCGATTCTGGTGCTGACCGCGCGCGACTCGGTGTCCGAGCGGGTGGCCGGGCTG
GACGCCGGTGCCGACGACTACCTACCAAAGCCGTTCGCCCTCGAAGAGCTGCTGGCACGGATGCGGGCGC
TGCTGCGCCGCACCAAGCCCGAGGATGCCGCCGAGTCGATGGCCATGAGGTTCTCCGACCTGACGCTGGA
CCCGGTAACCCGCGAAGTCAACCGTGGACAGCGCCGGATCAGCCTGACCCGCACCGAATTTGCATTGCTG
GAGATGCTGATCGCCAATCCGCGGCGAGTGCTGACGCGCAGCCGTATCCTGGAAGAGGTATGGGGATTCG
ACTTTCCCACCTCGGGCAACGCGCTGGAAGTCTACGTCGGGTATCTACGCCGCAAGACCGAGGCCGACGG
CGAGCCGCGGCTGATCCACACTGTGCGCGGAGTGGGTTACGTGCTACGTGAAACACCACCCTG
Protein Sequence 
>gi|148660762|ref|YP_001282285.1| two component response transcriptional regulatory protein MprA [Mycobacterium tuberculosis H37Ra] MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mprA mutant is attenuated in mice (Zahrt and Deretic, 2001).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Zahrt and Deretic, 2001: Zahrt TC, Deretic V. Mycobacterium tuberculosis signal transduction system required for persistent infections. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(22); 12706-12711. [PubMed: 11675502].