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pcaA from Mycobacterium tuberculosis H37Ra

Victor ID 1906
Gene Name pcaA from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215613
NCBI Protein GI 148660236
Locus Tag MRA_0476
Protein Accession YP_001281759.1
Other Database IDs UniProtKB-ID: A5TZJ7_MYCTA
UniRef100: UniRef100_Q7D9R5
UniRef90: UniRef90_Q7D9R5
UniRef50: UniRef50_A5U029
UniParc: UPI00000D5FB5
EMBL: CP000611
EMBL-CDS: ABQ72197.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066979.
EnsemblGenome_TRS: EBMYCT00000066984
EnsemblGenome_PRO: EBMYCP00000065094
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0476
eggNOG: COG2230
HOGENOM: HBG687502
OMA: MKLTHEI
ProtClustDB: CLSK790562
BioCyc: MTUB419947:MRA_0476-MONOMER
Taxonomy ID 419947
Gene Starting Position 562157
Gene Ending Position 563020
Gene Strand (Orientation) -
Protein Name mycolic acid synthase PcaA
DNA Sequence 
>gi|148659757:562157-563020 Mycobacterium tuberculosis H37Ra, complete genome
GTTACTTTTCCAGTGTGAACTGGTCGACGTCGGTGTAACCCTGGCGGAACAGCTTCGCGCAGCCGGTCAG
GTACTTCATGTAGCGGTCGTAGACAGTCTGCGACTGGATCGCGATGGCCTGATCTTTGTTGGCCTCGAGC
GCTGTGGCCCACATGTCCAGCGTCCTGGCGTAGTGCAGCTGCAATGACTGGACCGCGGTGACCCGGAAGC
CGACCTTCTCGGCGTACTCGTGCACCGTCGGGATGGACGGCAGCCAGCCACCGGGGAAGATCTCGGCCAG
GATGAATTTGGTGAAGTGAACCAGTTCGTGGGTCAACGTCAGGCCCTTTTCCCTGCCTTCTTTGAAGGTG
GGGCGCACGATGGTGTGCAGCAACATCTTGCCGTCGGCCGGCAACGTGCGGTGGGTCACCTCGAAGAAAT
GGTGGTAGCGCTGGTGGCCGAAGTGCTCGAACGCGCCGATCGAGACGATGCGGTCGACGGGCTCGTCAAA
TTTCTCCCATCCCTCCAGCAACACTCGTCTGGAGCGGGGGGTGTCCATTTGGTCGAACATTTTCTGGACA
TGACCGGCCTGGTTCTCCGACAACGTCAGGCCCACGACATTGACGTCGTATTTCTCGATGGCGCGCCGCA
TGGTCGCGCCCCAGCCGCAGCCGATGTCCAGCAACGTCATCCCGGGTTCGAGGTTCAGCTTGCCCAGGGC
CAGGTCGATCTTGGCGATCTGGGCCTCCTGCAGCGTCATGTCGTCGCGTTCGAAGTAGGCACAGCTGTAG
GTCTGGGTGGGGTCCAAGAACAGCCGGAAAAAGTCGTCGGAGAGGTCGTAATGAGCTTGCACGTTTCCAA
AATGCGGCGTGAGCTGCACGGACA
Protein Sequence 
>gi|148660236|ref|YP_001281759.1| mycolic acid synthase PcaA [Mycobacterium tuberculosis H37Ra] MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pcaA mutant is attenuated in mice (Glickman et al., 2000).
COG COG2230M, under M: Cell wall/membrane/envelope biogenesis
References
Glickman et al., 2000: Glickman MS, Cox JS, Jacobs WR Jr. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Molecular cell. 2000; 5(4); 717-727. [PubMed: 10882107].