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lysS

Victor ID 102
Gene Name lysS
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885428
NCBI Protein GI 15608778
Locus Tag Rv1640c
Protein Accession NP_216156.1
Other Database IDs UniProtKB-ID: LYSX_MYCTU
UniRef100: UniRef100_A5U2Z7
UniRef90: UniRef90_C6DS31
UniRef50: UniRef50_A0QHC4
UniParc: UPI000013650D
EMBL: BX842577
EMBL: AE000516
EMBL-CDS: CAB06635.1
EMBL-CDS: AAK45947.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000001495
EnsemblGenome_TRS: EBMYCT00000001495
EnsemblGenome_PRO: EBMYCP00000001495
EnsemblGenome: EBMYCG00000069937
EnsemblGenome_TRS: EBMYCT00000069942
EnsemblGenome_PRO: EBMYCP00000068001
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 1848516
Gene Ending Position 1852034
Gene Strand (Orientation) -
Protein Name lysyl-tRNA synthetase
DNA Sequence 
>gi|57116681:1848516-1852034 Mycobacterium tuberculosis H37Rv, complete genome
GCTAATGCGGTTTTGCCAACGGAAAGGGCAGTGTTTCGCGAATGCTGCGCCCAGTGATCAGCATGACCAC
CCGGTCAATGCCCATGCCCAAGCCGCCGGTGGGCGGCATGGCGTACTCCATCGCTTGCAGGAAGTCTTCG
TCGAGTTCCATCGCCTCGGGGTCTCCGCCGGCGGCCAGCAGGGACTGCTCCTGCAGGCGGCGCCGTTGCT
CCACCGGGTCGGTCAGCTCGCTGTAGGCGGTGCCCAGCTCGATACCCCACGCCACCAGGTCCCAACGCTC
GGCGACACCGCGCTTGCTGCGATGCGGTCGGGTCAACGGTGACACCGATGTCGGAAAGTCGATGTAGAAC
GTCGGTTGCTCGGTGCGGCACTCCACCAGGTGCTCGTATAGCTCGAGCACGACCGCGCCGGCATCCCATT
GGGTCCGATAGGGGACACCGGCGGCGTCGCACAGCTTGCGGAGAGTGGTCAAGCCGGTATCGGCGTCGAT
GCGTTCACCGAGTGCTTCCGAGATCGCATCATGCACCGTCCGCACCGGCCATATCCCGGAGATGTCGACC
GGTTCGAGGTGGTGGCGGGTGCCGTCGGAACCCTTGTCCGTCCGGGGCCGCATGGCGATGGGCGCCCCGT
TGGCGGCCTGGGCGGCGTTCTGGATGAGTTCGCGGCAGCCGTCAATCCACTCAAGGTAGTCGGCGTGTGC
TTGATAGGCCTCCAGTAGGGTGAACTCCGGGTTGTGGCTGAAGTCGACGCCCTCGTTGCGAAAGGCACGG
CCGAGCTCGAATACCCGTTCCACGCCGCCGACGCACAGGCGCTTGAGGTAGAGCTCTGGTGCGATGCGCA
GGAACAGATCCATGGAATACGTGTTGATGTGCGTGACGAACGGTCGGGCGGTGGCGCCGCCGTGCAGCTG
CTGTAGGATCGGCGTTTCGACCTCGACGAATCCCTTTGCGAACAGCGTCTCGCGCACAGCGCGCAGCACG
CTGCTGCGAGCGGTGATCAGCGCACGGGACTCAGCGTTGACCGCCAGGTCGAGGTAACGGGTCCGGACTC
GGGCTTCGGGATCCAGTAGCCCCTTCCACTTATTCGGCAACGGTCGCAAACACTTACCGATCAGGCGCCA
GCCGCTGACGATCAACGATGGAGTTCCGGTCTTGCTGGCGCCCATGTGTCCGGTCATCTCCACCAGATCA
CCCAGATCGGTCGCCGCGTTGAAGTCGGCCGCGCAGCCCTGGTCCAGGCGTGAATTATCCAGCAGCACTT
GCATTTCGCCCGACCAGTCGCGCAGCTGGGCGAACAACACACCACCGTAGTTACGTATTCGCATGATGCG
TCCGGACACCGACACGCTAGCCTGGTGGTCTGCGGCCAGCGCCTGTGCCACCGTGTGACTGGGCGGCCGG
CCCACGGGAAAGGCGTCAATGCCGCTGCTCCGCAGCTTCTCTAGCTTGTCGAACCGAACTCGCACCTGCT
CGGGTAGCCGCCGCTCGACCCCGTCGCCATTGGTGAGGCCTACTTGCCGCAGCCCGCTCACGTCCGGTGC
CGAGCCGTCGTGATGCAATAGGCCGGTGGCCGCCAACCGCTCGGGCACTGCCGGATGATGCCCCGTGTGT
ACTCGGTTGCGCCGGCTGAACGGCAGCACGAGGAACCCCTCTGCGATCACCGAGGCGACGCCCACTCGGG
GAATCACTCGGGCGTCTTCGTAGCAGGCGTAGCGCGGTACCCATTCGGGTTGGTACTTCATGTTGGAGCG
GTAGAGCGTCTCGAGCTGCCACCACCGTGAGAAGAAGACCAGCAGCCCCCGCCACAACCGGGCAACCGGG
CCGGCGCCGAGTTGGGCGCCCTGCTCGAAGGCCGCGCGAAACACCGCGAAGTTCAACGAAATACGAGTGA
TACCAAGGCTTTCAGCGTGCAAGGCGAGTTCGCTGACCATAAGTTCGATAGTGCCGTTCGGGGATTGTGG
AGAACGACGCATCAAATCCAGGGAGACACCGGTGGTTCCCCACGGCACCAGCGACAGCATTGCCAGCACC
TGGTTGTGCGGATCAATCGCCTCCACCAGCAGGCAGTCGGAGTCCGCGGGGTCGCCGAGGCGGCCCAGCG
CCATCGAGAAGCCGCGCTCGGTCTCGGTGTCGCGCCAGGAATCCGCCCGTGTGATGGTCTGCGCCATCTC
GTCTTCGGCAATGTCGCGATGCCGCCGGATGCGCACCGTCAACCCCGCCCGCCGGGCCCGCGTCACGGCC
TGGCGCACCCCGCGCATCTCCGGGCCGGACAACTTGAAATCGGCTGGCCGCAGGATGGCCTCATCGCCCA
GCTCGAGCGCGGTTAGGCCCGCTTCGCGATATGTCTGAGCCCCTTGTGAACTGGCGCCCATCACGCCGGG
TGCCCAGCCGTAGGTCTGGCACAGCCGCAGCCACGCGTCGACGGCCTGCGGCCATGCTCTGTGGTCGCCT
ACCGGGTCGCCGCTGGCTAGGCAGACACCGACCTCGACACGGTAGGTGATACAGGCGCGGCCGCTGGATG
CGAATACCACCGACTTGTCGCGACGGGTGGCGAAGTAGCCCAGTGAGTCGTCCTTCCCATACAAATCCAA
TAACCCGCGGATAGCGGATTCGTCCTCTCCGGTCAGCGCATTGTCAGCGCGCTGAGATAGGAACAAGACG
ATCGCAGCCCCGATCAACGCGAACGCGCCGAACAACCCGAAGATCGCGTTGAGGAAGACGTGCGGTCTGC
CGGTGAACAGATCGGGATCGGCGAGGGCGAATCCGACCACCCGGTTGGCCGCGTAACCCAACCGCTCGTC
CGGCGCTAGTGATCCCGGAAACAGTTCGACCAGACCCCAAGACGCCACGATTCCGACCACCGCGCCGGCA
AGCCACACCGCAGCCGCCCGAAACAGCGCGCCCCTGCGGACCTTGGCCCAGAACTCCCGATAGCCCAGCA
CCAGAACGACGATTGCCACAACATGCACGGCGAATCCGAGATTCTCCCCGAAGCTCTCGGCGGCGGTGTT
GCCGCCCGCTGCGATCTCGGCGGCGTTGACCACGGCGGCCAGGACCATATTTGCCAGCAAGACCAACCAG
GCAATGCGTTTGCGTGCCGTTAACGCGGCGGCCAGCAATGCCAGCACGAAGGACCACGCGAAGTTGGTGT
CGGGGAAGTTGAACAGATAATCGTTGATGAATTCGCGCGGAACCTTGATGATCCACCGAATCAACGGCGA
CACACTGGCCAGTAGTGACAGGGTCGCGATCACGCCGACGGTCCAGCCGGCTGCCGCGGGAACCCAGTGA
TACCGGGAGTTTCCCCTGGTGGCCGAGCGAGGTTTGGTGAGTGTCACAGACCGCGAGGATATTCCCAAAA
GCCGGGAAATGCCCGGCGTTGCAGCCCTTTGTAGCCCCGCATCGGTGTGCTGAGGGCACCGGCTGATGTC
GGCCGTTGTCTTAGATGACGTGTCATGGCTGTTAGACTGGACGCCGCGACCATCCCGGCGAAGGCCAGGG
ACAGTTAAGTGGAGTCCCA
Protein Sequence 
>gi|15608778|ref|NP_216156.1| bifunctional lysine--tRNA ligase/phosphatidylglycerol lysyltransferase [Mycobacterium tuberculosis H37Rv] MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQRAATPGISRLLGISSRSVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLIRWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAVVNAAEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVVGIVASWGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFALIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFASSGRACITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQTYREAGLTALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITRADSWRDTETERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLMRRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGAQLGAGPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRNRVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLEKLRSSGIDAFPVGRPPSHTVAQALAADHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIVSGWRLIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETPILQQLHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLEWIDGCRELIQNAAQAANGAPIAMRPRTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAAGVPYRTQWDAGAVVLELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPFPLAKPH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG1190J, under J: Translation, ribosomal structure and biogenesis
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].