Victors

Rv1747
Victor ID	96
Gene Name	Rv1747
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
NCBI Gene ID	885311
NCBI Protein GI	15608885
Locus Tag	Rv1747
Protein Accession	NP_216263.1
Other Database IDs	UniProtKB-ID: O65934_MYCTU UniRef100: UniRef100_A5U3A7 UniRef90: UniRef90_A5U3A7 UniRef50: UniRef50_A0QSY1 UniParc: UPI00000D4FE6 EMBL: BX842577 EMBL-CDS: CAB09333.1 RefSeq_NT: NC_000962.2 EnsemblGenome: EBMYCG00000001576. EnsemblGenome_TRS: EBMYCT00000001576 EnsemblGenome_PRO: EBMYCP00000001576 GenomeReviews: AL123456_GR KEGG: mtu:Rv1747 TubercuList: Rv1747 HOGENOM: HBG480618 OMA: GVTWTIE ProtClustDB: CLSK791370
Taxonomy ID	83332
Gene Starting Position	1973629
Gene Ending Position	1976226
Gene Strand (Orientation)	+
Protein Name	PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER
DNA Sequence	>gi\|57116681:1973629-1976226 Mycobacterium tuberculosis H37Rv, complete genome GGTGCCGATGAGCCAACCAGCCGCCCCGCCCGTGTTGACCGTGCGGTATGAGGGATCGGAGCGCACGTTC GCCGCAGGACACGATGTCGTCGTCGGGCGTGACCTGCGCGCGGATGTCCGCGTCGCACACCCCCTGATCT CCCGGGCACACCTGCTGCTGCGATTCGACCAGGGTCGCTGGGTCGCCATTGACAATGGCAGCCTCAATGG GCTCTACCTCAATAACCGTCGGGTGCCAGTCGTGGACATCTACGATGCCCAGCGAGTCCATATCGGAAAC CCCGACGGTCCGGCGCTGGACTTCGAAGTGGGCCGCCACCGGGGTTCGGCCGGGCGACCACCCCAGACGA CGTCGATACGCCTGCCCAACCTGTCCGCGGGAGCGTGGCCCACCGACGGCCCGCCGCAGACCGGCACGCT CGGCTCCGGCCAGCTACAACAGCTTCCACCGGCCACCACCCGGATACCCGCCGCTCCGCCATCGGGACCA CAGCCGCGATACCCCACCGGTGGGCAACAGTTGTGGCCACCCAGCGGACCGCAACGGGCGCCGCAGATTT ACCGGCCACCCACGGCCGCACCGCCGCCGGCGGGTGCCCGCGGCGGAACTGAGGCGGGAAACCTCGCGAC ATCGATGATGAAGATCCTGCGGCCAGGCAGGTTGACGGGGGAGTTGCCGCCCGGTGCCGTCAGGATCGGC CGGGCGAACGACAACGACATCGTCATTCCCGAGGTGTTGGCCTCACGTCACCACGCCACCCTGGTCCCGA CGCCTGGCGGCACGGAGATTCGGGACAACCGCAGCATCAATGGCACCTTCGTCAACGGCGCCCGGGTCGA CGCGGCGCTGCTGCACGACGGCGACGTCGTGACCATCGGCAACATCGACCTCGTCTTCGCCGACGGCACC CTGGCGCGCCGTGAAGAGAACCTGCTGGAGACCCGCGTCGGCGGCCTCGACGTGCGCGGGGTGACCTGGA CCATCGATGGCGACAAGACACTGCTGGACGGCATCTCGTTGACGGCGCGCCCCGGTATGCTCACCGCCGT CATCGGTCCGTCGGGCGCTGGCAAGTCGACACTTGCCCGGTTGGTGGCTGGGTATACGCACCCGACGGAT GGCACGGTGACGTTCGAGGGCCACAACGTTCACGCCGAATATGCCTCGCTGCGCAGCAGGATCGGCATGG TGCCACAGGACGACGTGGTGCACGGTCAGCTGACCGTGAAACACGCGCTGATGTATGCCGCCGAACTACG GCTGCCGCCGGACACCACCAAAGATGACCGCACCCAGGTAGTTGCCCGGGTGCTCGAAGAACTCGAGATG TCCAAGCACATCGACACCAGGGTCGACAAGCTGTCGGGTGGTCAACGCAAGCGGGCGTCGGTGGCGCTTG AGCTGTTGACCGGGCCGTCACTGCTGATCCTCGACGAGCCGACATCCGGCCTAGATCCTGCGCTGGACCG GCAGGTCATGACCATGCTGCGGCAGTTGGCCGACGCCGGTCGGGTGGTGCTCGTGGTTACCCACTCACTG ACCTACCTGGACGTCTGTGACCAGGTTCTGCTGTTGGCCCCCGGCGGCAAGACCGCGTTCTGTGGGCCAC CGACTCAGATTGGTCCGGTCATGGGGACCACGAACTGGGCCGACATCTTCAGCACCGTCGCCGACGACCC AGACGCGGCCAAAGCCCGCTACCTGGCGCGGACGGGTCCGACCCCACCACCGCCACCGGTCGAGCAACCC GCCGAACTGGGCGATCCGGCCCATACCAGCTTGTTTCGGCAGTTCTCCACGATCGCGCGGCGACAGTTGC GATTGATCGTTTCCGACCGAGGTTACTTCGTCTTTCTGGCGCTGTTGCCGTTCATCATGGGTGCGCTGTC CATGTCGGTACCGGGCGACGTGGGCTTCGGGTTTCCCAACCCGATGGGTGACGCGCCCAACGAGCCCGGC CAGATCCTAGTGTTGCTGAATGTCGGTGCGGTCTTCATGGGGACCGCGCTGACCATTCGTGACCTCATCG GTGAGCGAGCCATCTTCCGGCGCGAACAGGCAGTCGGCCTGTCCACTACCGCCTACCTGATCGCGAAGGT CTGTGTCTACACCGTGCTCGCGGTGGTTCAGTCGGCGATTGTGACGGTGATCGTCCTGGTCGGCAAGGGC GGTCCGACTCAGGGTGCCGTAGCGTTGAGCAAGCCAGATCTGGAGCTGTTCGTTGATGTCGCGGTGACCT GTGTCGCCTCGGCGATGCTCGGATTGGCGCTGTCGGCGATCGCCAAGTCCAACGAACAGATCATGCCCCT GCTGGTCGTGGCGGTCATGTCGCAGCTGGTGTTCTCCGGAGGCATGATTCCGGTCACCGGACGTGTTCCC CTTGACCAGATGTCCTGGGTCACACCGGCGAGATGGGGTTTCGCGGCGTCGGCCGCTACGGTCGACCTGA TCAAATTGGTGCCCGGTCCGCTGACCCCGAAGGATTCGCATTGGCATCACACCGCCAGCGCGTGGTGGTT CGACATGGCCATGCTGGTAGCGCTCAGCGTTATCTACGTCGGCTTTGTGCGCTGGAAGATTCGCCTCAAG GCGTGCTA
Protein Sequence	>gi\|15608885\|ref\|NP_216263.1\| ABC transporter ATP-binding protein/permease [Mycobacterium tuberculosis H37Rv] MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHPLISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFEVGRHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPPSGPQPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRPGRLTGELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNGARVDAALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTLLDGISLTARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRSRIGMVPQDDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTRVDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKARYLARTGPTPPPPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPFIMGALSMSVPGDVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIFRREQAVGLSTTAYLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELFVDVAVTCVASAMLGLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMSWVTPARWGFAASAATVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFVRWKIRLKAC
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Rv1747 mutant is attenuated in mice (Curry et al., 2005).
COG	COG1131V, under V: Defense mechanisms
References	*Curry et al., 2005:* Curry JM, Whalan R, Hunt DM, Gohil K, Strom M, Rickman L, Colston MJ, Smerdon SJ, Buxton RS. An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice. Infection and immunity. 2005; 73(8); 4471-4477. [PubMed: 16040957].


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Rv1747