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pks10 from Mycobacterium tuberculosis H37Ra

Victor ID 1902
Gene Name pks10 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215526
NCBI Protein GI 148661456
Locus Tag MRA_1671
Protein Accession YP_001282979.1
Other Database IDs UniProtKB-ID: A5U317_MYCTA
UniRef100: UniRef100_A1KJ77
UniRef90: UniRef90_A1KJ77
UniRef50: UniRef50_C7NIH6
UniParc: UPI00000D1006
EMBL: CP000611
EMBL-CDS: ABQ73417.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000068514.
EnsemblGenome_TRS: EBMYCT00000068519
EnsemblGenome_PRO: EBMYCP00000066629
GenomeReviews: CP000611_GR
KEGG: mra:MRA_1671
eggNOG: COG3424
HOGENOM: HBG588210
OMA: AMIAMGP
ProtClustDB: CLSK791301
BioCyc: MTUB419947:MRA_1671-MONOMER
Taxonomy ID 419947
Gene Starting Position 1875677
Gene Ending Position 1876738
Gene Strand (Orientation) +
Protein Name putative chalcone synthase Pks10
DNA Sequence 
>gi|148659757:1875677-1876738 Mycobacterium tuberculosis H37Ra, complete genome
AGTGAGCGTCATCGCAGGTGTGTTCGGCGCGTTGCCGCCGTATCGCTATTCACAACGCGAGCTCACCGAC
TCGTTTGTCAGCATCCCGGATTTCGAGGGCTACGAAGACATCGTTCGCCAGCTGCACGCCAGCGCCAAAG
TCAACAGCCGCCACCTGGTCTTGCCGCTGGAGAAATACCCGAAGCTGACCGACTTCGGCGAGGCGAACAA
GATTTTCATCGAAAAAGCCGTGGACTTGGGCGTGCAAGCCCTGGCGGGGGCACTCGACGAGTCCGGTCTG
CGACCCGAGGATCTCGACGTGTTGATCACCGCCACGGTCACCGGACTGGCGGTGCCGTCGCTGGATGCCC
GGATCGCCGGGCGGCTGGGGCTGCGCGCCGATGTCCGGAGGGTGCCGCTGTTCGGGCTGGGCTGCGTGGC
CGGGGCGGCCGGGGTCGCCCGGCTGCACGACTACCTGCGCGGGGCCCCGGACGGCGTTGCCGCGTTGGTC
TCGGTCGAGCTGTGTTCACTCACGTATCCGGGATACAAGCCGACGCTGCCGGGCCTTGTCGGCAGTGCGT
TGTTTGCTGACGGCGCCGCGGCGGTGGTGGCCGCAGGTGTGAAGCGCGCCCAGGACATCGGCGCCGACGG
GCCGGACATCCTGGATTCGCGCAGCCATCTGTACCCCGACTCGCTGCGCACCATGGGATACGACGTCGGC
TCGGCCGGGTTCGAGCTCGTCCTATCACGGGACTTGGCGGCCGTGGTCGAGCAGTATCTGGGCAATGACG
TCACCACCTTCCTGGCTTCGCACGGCCTGAGCACCACCGACGTCGGCGCCTGGGTCACCCATCCCGGGGG
ACCCAAGATCATCAACGCCATCACCGAGACCCTCGACCTGTCGCCGCAGGCTCTCGAGCTGACGTGGCGC
TCGTTGGGCGAAATCGGGAATCTGTCGTCAGCGTCGGTGCTGCATGTGCTGCGTGACACCATCGCCAAAC
CGCCCCCCAGCGGAAGTCCCGGGTTGATGATCGCCATGGGCCCAGGCTTCTGTTCCGAACTCGTGTTGCT
GCGCTGGCACTG
Protein Sequence 
>gi|148661456|ref|YP_001282979.1| chalcone synthase Pks10 [Mycobacterium tuberculosis H37Ra] MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMGPGFCSELVLLRWH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks10 mutant is attenuated in mice (Sirakova et al., 2003).
COG COG3424Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sirakova et al., 2003: Sirakova TD, Dubey VS, Cynamon MH, Kolattukudy PE. Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis. Journal of bacteriology. 2003; 185(10); 2999-3008. [PubMed: 12730158].