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aceE

Victor ID 241
Gene Name aceE
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887246
NCBI Protein GI 15609378
Locus Tag Rv2241
Protein Accession NP_216757.1
Other Database IDs UniProtKB-ID: ODP1_MYCTU
UniRef100: UniRef100_Q10504
UniRef90: UniRef90_Q10504
UniRef50: UniRef50_Q10504
UniParc: UPI0000130BEF
EMBL: BX842579
EMBL: AE000516
EMBL-CDS: CAA94662.1
EMBL-CDS: AAK46585.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000000535
EnsemblGenome_TRS: EBMYCT00000000535
EnsemblGenome_PRO: EBMYCP00000000535
EnsemblGenome: EBMYCG00000072615
EnsemblGenome_TRS: EBMYCT00000072620
EnsemblGenome_PRO: EBMYCP00000070679
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 2512538
Gene Ending Position 2515243
Gene Strand (Orientation) +
Protein Name pyruvate dehydrogenase subunit E1
DNA Sequence 
>gi|57116681:2512538-2515243 Mycobacterium tuberculosis H37Rv, complete genome
TGTGGCGTCGTATTTGCCCGACATTGATCCCGAGGAGACCTCGGAGTGGCTGGAGTCCTTTGACACGCTG
CTGCAACGCTGCGGCCCGTCGCGGGCCCGCTACCTGATGTTGCGGCTGCTAGAGCGGGCCGGCGAGCAGC
GGGTGGCCATCCCGGCATTGACGTCTACCGACTATGTCAACACCATCCCGACCGAGCTGGAGCCGTGGTT
CCCCGGCGACGAAGACGTCGAACGTCGTTATCGAGCGTGGATCAGATGGAATGCGGCCATCATGGTGCAC
CGTGCGCAACGACCGGGTGTGGGCGTGGGTGGCCATATCTCGACCTACGCGTCGTCCGCGGCGCTCTATG
AGGTCGGTTTCAACCACTTCTTCCGCGGCAAGTCGCACCCGGGCGGCGGCGATCAGGTGTTCATCCAGGG
CCACGCTTCCCCGGGAATCTACGCGCGCGCCTTCCTCGAAGGGCGGTTGACCGCCGAGCAACTCGACGGA
TTCCGCCAGGAACACAGCCATGTCGGCGGCGGGTTGCCGTCCTATCCGCACCCGCGGCTCATGCCCGACT
TCTGGGAATTCCCCACCGTGTCGATGGGTTTGGGCCCGCTCAACGCCATCTACCAGGCACGGTTCAACCA
CTATCTGCATGACCGCGGTATCAAAGACACCTCCGATCAACACGTGTGGTGTTTTTTGGGCGACGGCGAG
ATGGACGAACCCGAGAGCCGTGGGCTGGCCCACGTCGGCGCGCTGGAAGGCTTGGACAACTTGACCTTCG
TGATCAACTGCAATCTGCAGCGACTCGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAGCTGGA
GTCGTTCTTCCGCGGTGCCGGCTGGAACGTCATCAAGGTGGTGTGGGGCCGCGAATGGGATGCCCTGCTG
CACGCCGACCGCGACGGTGCGCTGGTGAATTTAATGAATACAACACCCGATGGCGATTACCAGACCTATA
AGGCCAACGACGGCGGCTACGTGCGTGACCACTTCTTCGGCCGCGACCCACGCACCAAGGCGCTGGTGGA
GAACATGAGCGACCAGGATATCTGGAACCTCAAACGGGGCGGCCACGATTACCGCAAGGTTTACGCCGCC
TACCGCGCCGCCGTCGACCACAAGGGACAGCCGACGGTGATCCTGGCCAAGACCATCAAAGGCTACGCGC
TGGGCAAGCATTTCGAAGGACGCAATGCCACCCACCAGATGAAAAAACTGACCCTGGAAGACCTTAAGGA
GTTTCGTGACACGCAGCGGATTCCGGTCAGCGACGCCCAGCTTGAAGAGAATCCGTACCTGCCGCCCTAC
TACCACCCCGGCCTCAACGCCCCGGAGATTCGTTACATGCTCGACCGGCGCCGGGCCCTCGGGGGCTTTG
TTCCCGAGCGCAGGACCAAGTCCAAAGCGCTGACCCTGCCGGGTCGCGACATCTACGCGCCGCTGAAAAA
GGGCTCTGGGCACCAGGAGGTGGCCACCACCATGGCGACGGTGCGCACGTTCAAAGAAGTGTTGCGCGAC
AAGCAGATCGGGCCGCGGATAGTCCCGATCATTCCCGACGAGGCCCGCACCTTCGGGATGGACTCCTGGT
TCCCGTCGCTAAAGATCTATAACCGCAATGGCCAGCTGTATACCGCGGTTGACGCCGACCTGATGCTGGC
CTACAAGGAGAGCGAAGTCGGGCAGATCCTGCACGAGGGCATCAACGAAGCCGGGTCGGTGGGCTCGTTC
ATCGCGGCCGGCACCTCGTATGCGACGCACAACGAACCGATGATCCCCATTTACATCTTCTACTCGATGT
TCGGCTTCCAGCGCACCGGCGATAGCTTCTGGGCCGCGGCCGACCAGATGGCTCGAGGGTTCGTGCTCGG
GGCCACCGCCGGGCGCACCACCCTGACCGGTGAGGGCCTGCAACACGCCGACGGTCACTCGTTGCTGCTG
GCCGCCACCAACCCGGCGGTGGTTGCCTACGACCCGGCCTTCGCCTACGAAATCGCCTACATCGTGGAAA
GCGGACTGGCCAGGATGTGCGGGGAGAACCCGGAGAACATCTTCTTCTACATCACCGTCTACAACGAGCC
GTACGTGCAGCCGCCGGAGCCGGAGAACTTCGATCCCGAGGGCGTGCTGCGGGGTATCTACCGCTATCAC
GCGGCCACCGAGCAACGCACCAACAAGGCGCAGATCCTGGCCTCCGGGGTAGCGATGCCCGCGGCGCTGC
GGGCAGCACAGATGCTGGCCGCCGAGTGGGATGTCGCCGCCGACGTGTGGTCGGTGACCAGTTGGGGCGA
GCTAAACCGCGACGGGGTGGCCATCGAGACCGAGAAGCTCCGCCACCCCGATCGGCCGGCGGGCGTGCCC
TACGTGACGAGAGCGCTGGAGAATGCTCGGGGCCCGGTGATCGCGGTGTCGGACTGGATGCGCGCGGTCC
CCGAGCAGATCCGACCGTGGGTGCCGGGCACATACCTCACGTTGGGCACCGACGGGTTCGGCTTTTCCGA
CACTCGGCCCGCCGCTCGCCGCTACTTCAACACCGACGCCGAATCCCAGGTGGTCGCGGTTTTGGAGGCG
TTGGCGGGCGACGGCGAGATCGACCCATCGGTGCCGGTCGCGGCCGCCCGCCAGTACCGGATCGACGACG
TGGCGGCTGCGCCCGAGCAGACCACGGATCCCGGTCCCGGGGCCTA
Protein Sequence 
>gi|448824781|ref|NP_216757.3| pyruvate dehydrogenase E1 component [Mycobacterium tuberculosis H37Rv] MASYLPDIDPEETSEWLESFDTLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTSDQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGVAMPAALRAAQMLAAEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENARGPVIAVSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG2609C, under C: Energy production and conversion
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].