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pks10 from Mycobacterium tuberculosis H37Rv

Victor ID 86
Gene Name pks10 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885112
NCBI Protein GI 15608798
Locus Tag Rv1660
Protein Accession NP_216176.1
Other Database IDs UniProtKB-ID: P94995_MYCTU
UniRef100: UniRef100_A1KJ77
UniRef90: UniRef90_A1KJ77
UniRef50: UniRef50_C7NIH6
UniParc: UPI00000D1006
EMBL: AE000516
EMBL: BX842577
EMBL-CDS: AAK45967.1
EMBL-CDS: CAB06631.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000002981.
EnsemblGenome_TRS: EBMYCT00000002983
EnsemblGenome_PRO: EBMYCP00000002983
EnsemblGenome: EBMYCG00000070036.
EnsemblGenome_TRS: EBMYCT00000070041
EnsemblGenome_PRO: EBMYCP00000068100
GenomeReviews: AE000516_GR
GenomeRev
Taxonomy ID 83332
Gene Starting Position 1874159
Gene Ending Position 1875220
Gene Strand (Orientation) +
Protein Name Possible chalcone synthase pks10
DNA Sequence 
>gi|57116681:1874159-1875220 Mycobacterium tuberculosis H37Rv, complete genome
AGTGAGCGTCATCGCAGGTGTGTTCGGCGCGTTGCCGCCGTATCGCTATTCACAACGCGAGCTCACCGAC
TCGTTTGTCAGCATCCCGGATTTCGAGGGCTACGAAGACATCGTTCGCCAGCTGCACGCCAGCGCCAAAG
TCAACAGCCGCCACCTGGTCTTGCCGCTGGAGAAATACCCGAAGCTGACCGACTTCGGCGAGGCGAACAA
GATTTTCATCGAAAAAGCCGTGGACTTGGGCGTGCAAGCCCTGGCGGGGGCACTCGACGAGTCCGGTCTG
CGACCCGAGGATCTCGACGTGTTGATCACCGCCACGGTCACCGGACTGGCGGTGCCGTCGCTGGATGCCC
GGATCGCCGGGCGGCTGGGGCTGCGCGCCGATGTCCGGAGGGTGCCGCTGTTCGGGCTGGGCTGCGTGGC
CGGGGCGGCCGGGGTCGCCCGGCTGCACGACTACCTGCGCGGGGCCCCGGACGGCGTTGCCGCGTTGGTC
TCGGTCGAGCTGTGTTCACTCACGTATCCGGGATACAAGCCGACGCTGCCGGGCCTTGTCGGCAGTGCGT
TGTTTGCTGACGGCGCCGCGGCGGTGGTGGCCGCAGGTGTGAAGCGCGCCCAGGACATCGGCGCCGACGG
GCCGGACATCCTGGATTCGCGCAGCCATCTGTACCCCGACTCGCTGCGCACCATGGGATACGACGTCGGC
TCGGCCGGGTTCGAGCTCGTCCTATCACGGGACTTGGCGGCCGTGGTCGAGCAGTATCTGGGCAATGACG
TCACCACCTTCCTGGCTTCGCACGGCCTGAGCACCACCGACGTCGGCGCCTGGGTCACCCATCCCGGGGG
ACCCAAGATCATCAACGCCATCACCGAGACCCTCGACCTGTCGCCGCAGGCTCTCGAGCTGACGTGGCGC
TCGTTGGGCGAAATCGGGAATCTGTCGTCAGCGTCGGTGCTGCATGTGCTGCGTGACACCATCGCCAAAC
CGCCCCCCAGCGGAAGTCCCGGGTTGATGATCGCCATGGGCCCAGGCTTCTGTTCCGAACTCGTGTTGCT
GCGCTGGCACTG
Protein Sequence 
>gi|15608798|ref|NP_216176.1| chalcone synthase [Mycobacterium tuberculosis H37Rv] MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMGPGFCSELVLLRWH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks10 mutant is attenuated in mice (Sirakova et al., 2003).
COG COG3424Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sirakova et al., 2003: Sirakova TD, Dubey VS, Cynamon MH, Kolattukudy PE. Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis. Journal of bacteriology. 2003; 185(10); 2999-3008. [PubMed: 12730158].