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sigH from Mycobacterium tuberculosis H37Rv

Victor ID 291
Gene Name sigH from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888094
NCBI Protein GI 15610359
Locus Tag Rv3223c
Protein Accession NP_217739.1
Other Database IDs UniProtKB-ID: RPOE_MYCTU
UniRef100: UniRef100_P66808
UniRef90: UniRef90_P66808
UniRef50: UniRef50_P66808
UniParc: UPI0000033263
EMBL: BX842582
EMBL: AE000516
EMBL-CDS: CAB08314.1
EMBL-CDS: AAK47662.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
DIP: DIP-13485N
EnsemblGenome: EBMYCG00000000644
EnsemblGenome_TRS: EBMYCT00000000644
EnsemblGenome_PRO: EBMYCP00000000644
EnsemblGenome: EBMYCG00000068955
EnsemblGenome_TRS: EBMYCT00000068960
EnsemblGenome_PRO: EBMYCP00000067019
GenomeReviews: AE000516_
Taxonomy ID 83332
Gene Starting Position 3598900
Gene Ending Position 3599550
Gene Strand (Orientation) -
Protein Name RNA polymerase sigma factor RpoE
DNA Sequence 
>gi|57116681:3598900-3599550 Mycobacterium tuberculosis H37Rv, complete genome
CTCATGACGACACCCCCTCGTGCGCCTGCTCGCCCCTGGCAAACCCCCGATCCCTGGCCACATCGGCTAA
AAGACCGCGCAACTGACGTCGGCCGCGATGAAGCCTCGACATCACGGTGCCGATCGGAGTATCCATGATC
TCGGCGATCTCCTTGTAGGGGAAACCTTCGACATCGGCGTAGTAGACCGCCATCCGGAACTCTTCCGGCA
ATGCCTGCAGCGCCTCTTTGATCTCGGTGTCCGGCAACGCTTCTAACGCTTCGACTTCAGCCGAGCGCAG
CCCGGTCGAGGAATGCTCGGCGTTGGACGCCAGTTGCCAATCGGTGATCTGCTCGGTCGGATACTCCGCC
GGTTGCCGCTGTTTCTTGCGATAGCTGTTGATGTAGGTGTTGGTCAGTATCCGGTAGAGCCAGGCCTTGA
GATTGGTACCGTGCCGGAACGAACGAAATCCCGCATAGGCCTTCACCATCGTCTCCTGGAGCAAGTCCTC
GGCGTCGGCCGGATTGCGCGTCATCCGCAGCGCACCGCCGTACAGCTGGTCCAACAGGGGAATCGCGTCG
CGCTCGAAACGCGCGGTCAACTCCTCGTCTGTCTCCTCAGACGGCCCAGGCTGCAGACCCGCCGAACCGG
TTACACCATCGATGTCGGCCA
Protein Sequence 
>gi|15610359|ref|NP_217739.1| ECF RNA polymerase sigma factor SigH [Mycobacterium tuberculosis H37Rv] MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002).
COG COG1595K, under K: Transcription
References
Kaushal et al., 2002: Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC, Fleischmann RD, Bishai WR. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(12); 8330-8335. [PubMed: 12060776].