Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

pks1 from Mycobacterium tuberculosis H37Ra

Victor ID 1870
Gene Name pks1 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212915
NCBI Protein GI 148662793
Locus Tag MRA_2973
Protein Accession YP_001284316.1
Other Database IDs UniProtKB-ID: A5U6V4_MYCTA
UniRef100: UniRef100_A5WRJ8
UniRef90: UniRef90_C6DWA7
UniRef50: UniRef50_C6DWA7
UniParc: UPI0000165323
EMBL: CP000611
EMBL-CDS: ABQ74754.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067102.
EnsemblGenome_TRS: EBMYCT00000067107
EnsemblGenome_PRO: EBMYCP00000065217
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2973
eggNOG: COG3321
HOGENOM: HBG669988
OMA: ADESAWR
ProtClustDB: CLSK792182
BioCyc: MTUB419947:MRA_2973-MONOMER
Taxonomy ID 419947
Gene Starting Position 3303494
Gene Ending Position 3308344
Gene Strand (Orientation) -
Protein Name putative polyketide synthase Pks1
DNA Sequence 
>gi|148659757:3303494-3308344 Mycobacterium tuberculosis H37Ra, complete genome
GCTAGGCATGGACCGATACTTCCGCGGCGGCGGGTTCGACAACCTGCGACGTCGGATCACCGGATTCCGT
TGGGCGGCTGCCAGACATTTGCTGGGCGACATACTCGGCGACCGCAGTGGGAGTGGGATGATCGAAAATC
ACGGTAGGTGGCAGCGTCAGTCCGGTGGCGGTTTTGAGGCGGTTGCGTAACTCCACAGCCGTTAATGAGT
CGAAACCGAGGTCGCCGAATTCGGTGTCGGGGTCGACGTCCTCGGCGGAGGGCCTACCCAGCACTGCCGC
TGCCTGCAGACACACCAGCCCCACTAGCAGCTCGAGTTGTTCGTCCGCGGCCAGCCCGTGTAGGCGTTGA
GCCAGCGCCGACTTCGACGAGGTGGCGTCACCGGTGTCGTCGATTTGGCGTCGGCGTGGGCGGCGCGCGA
GCCCGCTGAACAGCGCCGGCAACGCACCGGCCTGGGCCCGGGCGTCTAGTGCAGCCCGGTCCAAGAGCGT
GGCCACCGCCAGAGGGTGATCGATGGCCAGCGCAGCGTCAAACAATTCCACCGCTTCGGCAGGGCTCATC
GGAGCCAGCCCGCTGCGGCTCATGCGGGCCAGATCTCGGCTGCTCAAATGCGCGGTCATGCCGCCAGGCT
GTTCCCACAAACCCCACGCCAGTGATATCCCGGCCAACCCTGCGGCCTGCCGGTGAGCGGCCAACCCGTC
CAGAAACGCGTTTGCCGCCGAGTAGTTGCCCTGCCCCGGCGAGCCGACCGTGGCCGCGATCGATGAGCAC
AGCGCAAACATCGACAAATCCAGGTCACTGGTGGCCTGGTGCAGGTTCCACGCCGCGTCCACCTTGGCCC
GCAACACCGTATCGATGCGGTCCGGTGTCAACGAGGTGATCACTGCGTCATCGAGCACGCCGGCGGCATG
AATCACCCCGCGCACCGGCGGGTACTCCCGCGACAGCTGGGCAAACAACCCCGCTACCGCAGCGCGATCG
GCCACGTCACAGGCCACCACCTGCACCTTGGCGCCGGCCTCCGTCAAGTCGGCGGCCAATTCGGCCGCTC
CCTCCGCGCGATCGCCCCGCCGACTGGCCAACACCAGATGACGCACCCCATAGGCGCCAACCAGGTGGCG
GGCCAACACCCCACCAACCGCCCCGGTGGCACCGGTGATCACCACCGTGCCGTCGGCAAGCCGGTCGGCC
AACGCCGAGGGCATGGTTAAGACAACCTTGCCGATATGGCGGGCCTGGCTCATGAACCGGAAGGCCGCCG
GGGCGCAGCGCACATCCCACGTGGTGACCGGTAGCCGGTGCAGCTCCCGGGTGTCGAACAGCTCCCGCAC
CTCGGCCAACATCTCCTGCATGCGTGCCGGGCCGGCCTCCGACAGGTCGAACGCCCGATACTGCACGCCG
GGATAATTAGCGGCGATCTCCTGCGCATCGCGGATATCCGTCTTGCCCATCTCGAGGAAACGCCCACCGC
GGACCAGTAAGCGCAGCGACGCATCCACGAACTCACCGGCCAGCGAGTCGAGCACCACATCAACCCCGCG
GCCCTCGGTGACCGCCAGGAACTTCTCCTCGAACTCGCATGTGCGGGAATCGCCGATATGGTCGTCGTCA
AACCCCATGGCGCGCAGCGTGTCCCACTTGCCACGGCTGGCGGTGACGAAAACCTCCACGCCCCACTGGC
GAGCCAGCTGCACAGCCGCCATGCCCACACCGCCGGTACCGGCATGGATCAGCACCGATTCGCCCGCCTT
GATCTCGGCTAAATCGGCCAACCCGTACCAGGCCGTCAAGAACACCACCGGCACAGCGGCTGCCTGAGCA
AACGACCAGCCTTGCGGCACCCGGGTAACCAGTTGCTGATCCACCACCGCCAGCGGACCGGCCCCGCCCA
GGAATCCCATCACGGCGTCACCGACGGCAAGATCGGTCACTTCGGGACCGGTCTCAAGCACCACCCCGGC
GCCTTCGGCACCCAGCGGTGGGGCCTGGCCGGGATACATCCCTAGGGCGGCCACCACATCGCGGAAGTTG
ACCCCGACGGCCGCCACCGCCACGCGCACCTGCCCCGCCTGTAGCGGTGCCTGTACCTCCGGGCAGGGCT
GGATCACCAAATCCTCCAGGGTCCCGCCACCACCGGCGGCCAATCGCCACGCCGACTCTGCCGCCGGTAA
CGCTAGCAACGCCGGGGCCGGGGACAGCCGGGGGGCGTGCACAGTGCCGCCGCGCACCAGCAGCTGGGGT
TCCCCGACGCCGGCTAGCACCGAGGCATCCACCGCCGCATCGGTGTCGATCAACACGATCCGGCCGGGAT
TTTCGGCCTGCGCGGAACGCGCCATGCCCCACACCGCGGCGGCGGCCAGGTCGCTGATGTCCTCGCCAGC
CAGCCCCACGCCACCATGGGTCAACACCACCAACGTGGCCGCCCGATCCGCGCCGAGCCAGGACTGCAAC
ACCTCCAGGGCGGTGTGGGTGGCCGCATACACCGAGCCCACCACCGAGGATGCTTGGCCACCGGCAGACT
CGAGTTCCCACACCACGACACTGGCGTCACCATCACTGCCGGCGCAAAAGTCCGCCCAAGACACCGGGGC
AGGTGGGGCGGACCCGTTAGCGCCGCCGCTGACCACCGAGATCGGCGACCACACCACTTCCAGCGGCCCC
TGATCGGACGCACCGCCGGCCGCGGTCACGGCGGCGCGCAGCTGTTCTGCGGTTATCGGGCGAGTAACCA
GCGAGCGCACCGTCAACACCGGCAGCCCAGTGGCGTCGCAGACGTCCACGGAAATCGCATCCGCGCCCGC
GGACGCGAAGCGGGCCCGCACCCGTCCAGCGCCGCCGGCATGCAGCGACACCCCACGCCAGCAAAACGGC
AGTCTCGTCTCGGTGCTCGCCTGGGTCTTCTCGACGGCCAGCCCGAGGGCATGCAGCACCGCGTCCAACA
CCGCCGGATGCATCCCCATTCGGTCGACGGCCACGCCGGCCTCGCCGGGGGCTACAACTTCGGCGAACAG
CTCCGACCCCCGCCGCCAGATCGCCACCAGACCCTGAAACGCGGGGCCGTAGGCATAACCGCGCTCGGCC
AACTGCGCATAGCCGTCCGAGATATCCACACTCTCCGCGCCCTCGGGCGGCCACACGGACAAATCCATCG
GCGTCTCAGCGGCAGCCACCCCCAGCATGCCTTCGGCGTTCAGCAACCAACCCTGGGATTGATCACCGCG
GGAATACACCGACACCGCACGGTGCCCGGATTCATCGGCAGCCCCGACGACCACCTGCACCTGAACCCCG
ACACCCGGGTGCATCACCAACGGTGCGGCCAGCACCAACTCTTCGATGAGCGCGCACCCGACCTCATCAC
CGGCGCGGATCACCAACTCCACAAAACCCGCCCCGGGGAACAGCACCACCCCGTTCACCACGTGGTCGGC
CAGCCACGGCTGATCCGCAAGCGACAACCGGCCGGTCAGCACCACCTCGTCAGAATCGGGCCGCTCGACC
ACCGCACCCAACAAGGCATGCTCGGTCGCGCCCAGACCCAACCCGGCCGCATCGGCGGGCCCATCCGCGC
CCGGCGTCTCCCAAAACCGCCGTCGCTGAAACGCATACGTGGGCAGCTGCACCCGCCGTCCACCCGAGCC
GGCGAACACCGCCGACCACTGCACCGGCACACCGGTGGTGAACACCTGACCGGCAGCACCGAGCGCCGAG
GCCAGCTCGGGCCGGTCTTTGCCCAGCATCGACACCACCATCGCCTCAGCCGGGGCCAAGGACTGCTCGA
TCGAGCCAGTCAAACCACTTCCCGGGCCGGCCTCGATGAAGTGGGTCGCCCCAAGGGTCTGCAAATGACG
CGCACTGTCCGCGAAGCGCACCGGCCGACGAACGTGGTCCACCCAGTACTGCGCCGACCCGAAATCAGGG
CCGGCCAACTCGCCCGTCACGTTCGACACCAGCCCAAGCTGGGGCTCGCGTGCCTGCACCCGGGCCGCGA
CACGCGCGAACTCCTCGAGCATCGGCTCCATCAACGGCGAATGAAACGCATGCGAGACCGCCAACTGGTG
CACCCGCCGACCCTGCGCGGCGAACCGATCCGCAATCGCATTTGCCGCGGCCTGCGCACCGGAGATCACC
ACCGATTCGGGCGCGTTGATCGCAGCGATCCCCACACCCTCACCCAGCAGCGGCTCCACCTCGTCCTCAC
TGGCAGCCACCGCCACCATCGCACCGCCTGCCGGCAGCGCCTGCATCAACCGGCCCCGCGCCACCACCAG
CATCGCCGCGTCCGCCAACGTCAACACACCGGCCGCGTGCGCCGCCGCCAGCTCTCCAACGGAGTGACCC
ATGACGAAGTCCGGAAGCACACCCCAATCCCGCAACACCGCGAACGATGCCACCTCCACCGCGAACAACG
CGGGCTGAGCAAATTCGGTGCTGTCAAGCAAATCCGCATCGGCACCCCAAATAACGTCGCGCAGCGGCAA
CCGCAGATGCCGGTCCAACTCGTCGGCCACCGCATCGAATGCCTGCGCAAACACGGGCAACTCGCCGTAC
AACTCGCGGCCCATCCCGATGCGCTGCGCGCCCTGCCCAGGAAACACGACCACCGTCTTGCCCACCGACC
CTGGCTGACCGACCGCCACGCCGGCACCCGGCTCGCCCGCCGCGAGCCCAGCCAGCCCGGCAATCAGTTG
CTCACGGCTTGCGCCGACCACCACCGCTCGGTGCTCAAACACCGAGCGACTGGCCAACGAGCACCCCACA
TCGATCGGATCCAGCCCTGGGTTGGCCTGCACGTGGGCCATAAGTCGACCCGCCTGCGCCGTCAACGCCT
CAGCCGATCTCGCCGAAATCA
Protein Sequence 
>gi|148662793|ref|YP_001284316.1| polyketide synthase Pks1 [Mycobacterium tuberculosis H37Ra] MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks1 mutant is attenuated in mice (Sirakova et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sirakova et al., 2003: Sirakova TD, Dubey VS, Cynamon MH, Kolattukudy PE. Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis. Journal of bacteriology. 2003; 185(10); 2999-3008. [PubMed: 12730158].