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fadD21

Victor ID 144
Gene Name fadD21
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886065
NCBI Protein GI 15608325
Locus Tag Rv1185c
Protein Accession NP_215701.1
Other Database IDs UniProtKB-ID: FAD21_MYCTU
UniRef100: UniRef100_P63524
UniRef90: UniRef90_P63524
UniRef50: UniRef50_P86249
UniParc: UPI000012A5C2
EMBL: BX842575
EMBL: AE000516
EMBL-CDS: CAA15862.1
EMBL-CDS: AAK45479.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000000144
EnsemblGenome_TRS: EBMYCT00000000144
EnsemblGenome_PRO: EBMYCP00000000144
EnsemblGenome: EBMYCG00000069501
EnsemblGenome_TRS: EBMYCT00000069506
EnsemblGenome_PRO: EBMYCP00000067565
GenomeReviews: AE000516_GR
GenomeReview
Taxonomy ID 83332
Gene Starting Position 1325775
Gene Ending Position 1327511
Gene Strand (Orientation) -
Protein Name acyl-CoA synthetase
DNA Sequence 
>gi|57116681:1325775-1327511 Mycobacterium tuberculosis H37Rv, complete genome
CTCAGCCGTCCAACCGGGTGAATTGCTGCAGCCGGTATTGCTCTACACAGGCGGCCCTTCTGATCTTGCC
GCTGGTTGTGGTGGGGATCGACCCGGGCGGGACCAAGACGAGGTCCGCCACGTTGAGACCGTGCGAGCGT
GATATCGCGGCTGTGACGTTGTTCTTGATGACATCGAGTTCGTCCATCGCTTCGCCGGCGGAATCGCCGA
GGAGCTTGAGCTCGATGACAGTGACTAACTTCTCTGTGTGATCGACCGGAACTGAAATCGCAGCGACCCG
ACCACCAGTGATCTCCTGGACGGTCGACTCGATGTCCTCGGGGTAGTGATTGCGCCCGTATACGATCAGC
ATGTCCTTCATACGGCCCACGATGAACATCTCGTCCTCGGAGAGGAATCCGAGGTCTCCCGTTCGCAACC
AGGATCCATCAGGAGTACCTGCCGAGGGGTGGACCAGCATTGCGCCAAAGGTGTGCCGTGTCTCGTCCGG
TTTGTTCCAGTAGCCTTCGGCGACGTTGTCGCCCTTCACCCAGATCTCGCCGATCGTTCCCGCGGGGCAC
TCAATGCAGGTGTCGGGATCCACAATTCGCACTGTTGGTGATGTCGGCATGCCATAGCTCAGCAGCGGTG
TGCCGGTCTTGGGTTCACATCGATTCGCACTGCCCGTGGACAGCTTGTCAGGTTCGAAGTAGACGACTTC
TGGCTTGTCACCCGAATTGCGGCTGGCCACATAAAGAGTCGCTTCCGCCAGACCGTACGAAGGCCGTATC
ATGTCTTCGCGGAAATTGTACGGTGCAAACCGGTTGCAGAATCTACTGAGCGTGTTGGGGTGGACTCGTT
CAGCACCACTGGTGATGCCCAGGACGTTGCCGAGGTCGAGGCCTTCTATGTCGGCATCTGTTGTCTTGCG
GACGGCCAATTCGAAGGCGAAATTCGGTGCGGCCGACCACGAAGGACTTCCGTTGGCCAGCGAATGTAGC
CAACGCGCTGGCCGTTGCAGGAACGCCAGCGGGCTAGTGAGTTCACTGCGGTAGCCGCCCAGGATCGGTG
CGATGATGCCAAGGACCAAGCCCATGTCGTGGTAGAACGGCAGCCACGACACGATGGTAGTGTCAGGTGG
CGCCACACCGTTGCGGTCGCCGAAGTAGTTCGACATCAGCTGTTGGAAATTCGCCTGAAGGTTCCGATGC
GAGATCATGACCCCAGCCGGAGCGCGGGTGGAGCCAGAGGTGTACTGCAAGTACGCGGCGCTTGGCAGAT
CCTTCACCCGAAAGCTCGGTGAATTCCCGGTCAAGTCCAATGAATCGATTTCGATGATCGGCCCTACGTT
GTTCGTGTTCGGCCGGTGGATGTGCTCGGCAACCGCTTCTGCGACCGCAGATGTTGTCAGGATGACCGAA
GGTGACGCGTCGGCAAGCACCGCGCTGACACGTTCGTCGTGAGAGCCGATCTGCGGGACTGACAACGGAA
CCGCTATCGCTCCGGCCTGCATCGAACCTAGGAAAGCCGCGATGTAGGCCAGGCCCTGCGGAGCCAGAAT
CACGGCTCGGTCTCCGGTCGTGCAATGCCGCCTGACTTCGTGAGCAACGATGCGGGTCCGTCGAAACACC
TCTGACCACGTGAGCGTTTCGGTGATGCCGGCCCAATCCTGTTCGTAGTCGATGTACGTGAACGCGGCGT
CGTCGGGCTGCAGGCCGGCACGCTCGCGCAGCAAGGACAAGACAGAAGAGTCGGACA
Protein Sequence 
>gi|15608325|ref|NP_215701.1| fatty-acid--CoA ligase FadD21 [Mycobacterium tuberculosis H37Rv] MSDSSVLSLLRERAGLQPDDAAFTYIDYEQDWAGITETLTWSEVFRRTRIVAHEVRRHCTTGDRAVILAPQGLAYIAAFLGSMQAGAIAVPLSVPQIGSHDERVSAVLADASPSVILTTSAVAEAVAEHIHRPNTNNVGPIIEIDSLDLTGNSPSFRVKDLPSAAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYFGDRNGVAPPDTTIVSWLPFYHDMGLVLGIIAPILGGYRSELTSPLAFLQRPARWLHSLANGSPSWSAAPNFAFELAVRKTTDADIEGLDLGNVLGITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEATLYVASRNSGDKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYGMPTSPTVRIVDPDTCIECPAGTIGEIWVKGDNVAEGYWNKPDETRHTFGAMLVHPSAGTPDGSWLRTGDLGFLSEDEMFIVGRMKDMLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDHTEKLVTVIELKLLGDSAGEAMDELDVIKNNVTAAISRSHGLNVADLVLVPPGSIPTTTSGKIRRAACVEQYRLQQFTRLDG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].