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hbhA from Mycobacterium tuberculosis H37Rv

Victor ID 174
Gene Name hbhA from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886272
NCBI Protein GI 15607616
Locus Tag Rv0475
Protein Accession NP_214989.1
Other Database IDs UniProtKB-ID: HBHA_MYCTU
UniRef100: UniRef100_A1KFU9
UniRef90: UniRef90_A1KFU9
UniRef50: UniRef50_A1KFU9
UniParc: UPI000016522A
EMBL: AF074390
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: AAC26052.1
EMBL-CDS: CAB00936.1
EMBL-CDS: AAK44716.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000003027
EnsemblGenome_TRS: EBMYCT00000003029
EnsemblGenome_PRO: EBMYCP00000003029
EnsemblGenome: EBMYCG00000070751
EnsemblGenome_TRS: EBMYCT00000070756
EnsemblGenome_PRO: EBMYCP00000068815
Geno
Taxonomy ID 83332
Gene Starting Position 565796
Gene Ending Position 566395
Gene Strand (Orientation) +
Protein Name IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN)
DNA Sequence 
>gi|57116681:565796-566395 Mycobacterium tuberculosis H37Rv, complete genome
CATGGCTGAAAACTCGAACATTGATGACATCAAGGCTCCGTTGCTTGCCGCGCTTGGAGCGGCCGACCTG
GCCTTGGCCACTGTCAACGAGTTGATCACGAACCTGCGTGAGCGTGCGGAGGAGACTCGTACGGACACCC
GCAGCCGGGTCGAGGAGAGCCGTGCTCGCCTGACCAAGCTGCAGGAAGATCTGCCCGAGCAGCTCACCGA
GCTGCGTGAGAAGTTCACCGCCGAGGAGCTGCGTAAGGCCGCCGAGGGCTACCTCGAGGCCGCGACTAGC
CGGTACAACGAGCTGGTCGAGCGCGGTGAGGCCGCTCTAGAGCGGCTGCGCAGCCAGCAGAGCTTCGAGG
AAGTGTCGGCGCGCGCCGAAGGCTACGTGGACCAGGCGGTGGAGTTGACCCAGGAGGCGTTGGGTACGGT
CGCATCGCAGACCCGCGCGGTCGGTGAGCGTGCCGCCAAGCTGGTCGGCATCGAGCTGCCTAAGAAGGCT
GCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCGGCGGCCAAGAAGGCGC
CCGCGAAGAAGGCGGCGGCCAAGAAGGTCACCCAGAAGTA
Protein Sequence 
>gi|15607616|ref|NP_214989.1| heparin binding hemagglutinin HbhA [Mycobacterium tuberculosis H37Rv] MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hbhA mutant is attenuated in attachment and invasion of pneumocytes (Pethe et al., 2001).
References
Pethe et al., 2001: Pethe K, Alonso S, Biet F, Delogu G, Brennan MJ, Locht C, Menozzi FD. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature. 2001; 412(6843); 190-194. [PubMed: 11449276].