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mbtB from Mycobacterium tuberculosis H37Rv

Victor ID 124
Gene Name mbtB from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885838
NCBI Protein GI 15609520
Locus Tag Rv2383c
Protein Accession NP_216899.1
Other Database IDs UniProtKB-ID: MBTB_MYCTU
UniRef100: UniRef100_P71717
UniRef90: UniRef90_Q7TYQ4
UniRef50: UniRef50_Q1B6A7
UniParc: UPI00000D5001
EMBL: BX842579
EMBL: AE000516
EMBL-CDS: CAB03756.1
EMBL-CDS: AAK46746.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
HSSP: P0ADI4
EnsemblGenome: EBMYCG00000000207
EnsemblGenome_TRS: EBMYCT00000000207
EnsemblGenome_PRO: EBMYCP00000000207
EnsemblGenome: EBMYCG00000069508
EnsemblGenome_TRS: EBMYCT00000069513
EnsemblGenome_PRO: EBMYCP00000067572
GenomeReviews: AE000516_GR
Taxonomy ID 83332
Gene Starting Position 2671592
Gene Ending Position 2675836
Gene Strand (Orientation) -
Protein Name PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE)
DNA Sequence 
>gi|57116681:2671592-2675836 Mycobacterium tuberculosis H37Rv, complete genome
GTTATCGGACATCGGCACTCACCATCCGGGCCACGGCGTCGAGGTGATCGTTGAGATAGAAGTGACCACC
ATCAAAGTGCGACAGCGTGAAGCGACCGGAGGTGTGAGTCTCCCAACTGGTCAACATCTCCCGGCTGATG
CGGTGGTCGCGGTTGCCGCCGACCGCGTGGATGTTGGCGCGGATGCGCACGTCGGGTGGACATGAATAGC
CGCTGAGGGCCCGATAGTCGGCCTTGACCGCCGGCACCAGCAGTTCAACGAATTCCTCGTCCTCGAGCAG
CACGGGATCGGTGCCGCCAAGATCCACCATGTCGGCCAGGACGTCACGGTCGGCGGTCGGCAACGGTCCG
GACGCGGCCACCGTCGACGGAGCCTGACCGGAGGAAGCCCACAGTGCACGTACCGGCACGCCATTGCGCT
CGGCGAGGCGAGCGAACTCGAAGGCCACTATCGCACCCATGCAATGGCCGAACAGCGTCAGCGGAGCCGT
CAGGTGCCAGTCGCCCGCCTCGAACAGCTCGAGCGCCAGCGCCTCGATGCTGTCTGCCGCCGGGTGGCTG
CGCCGGTCAGCCCGCTGCGGGTACTGCACCACGAACGTGTCAACGTCGTTGGCCACTAACGATTTTGCCA
ACCACCGGTAAGCCGCGGCAGCGCCGCCGGCGTGTGGAAACACCAGCACCGCGCCGGGCTTGTCAGTACC
GGTGAACCGCTTCACCCACGGTTTGAAGGCTGGCTGTGCGGGCTGCTCGATCGGATCGAGCGCCGCCATC
ACGTCGGCACTTGTCATATTCGCGATTTCTAAGTACACCTCGGCGACCAGTTCGAGTCGGTCGGCGTTGG
CTTCCCGACCGGTGAGCAACTGGGCCAACGCGGCAATGGTCCTGGCGGCAAACATGTCGGCGACCATCAG
GCTCGGCGAATCCAGCCACCGCCGGATACCGGCGACGACCTGGGTCGCAAGCACGGAATCGCCGCCCAGG
GCAAAGAAGTCGTCGTGCACGCCCACGGCATCGTTGGCACGGCCCAGGATGTCCGCGACGATGCGGCGCA
GTGCCCGCTGAAGCACCGTTCGCGGCGCCGCATAGGGTGCCGATCTGTCGCCAGACCGCTCGACCTCGGC
GGCAAGCAGGGCGCCAACCTCCGCGCGGTCGATCTTGCCGCTGTCGGTAAAGGGGATGCGGTCTAGCAGC
GTGACGTGGCGCGGAATCATGTGCGCGGGCACCAGATCGGCGAGCTGCTGTCGAATCGACTCCGCGGTCA
CGCCGGCATCGTCGACGCAGACCGCCGCGGCCAGCACATCGGACCCGCCAGGAAGCACGGTGGCCGCCGC
CGCGTGCACACCGGGCAAGCGCTGCAGCGCGGCTTCGATCTCGCCGAGTTCGACGCGGTACCCGCTGATC
TTGACGCGGTGATCGGCACGGCCGACGAACTCCAGGGTGCCGTCGTGCCAGTAGCGGGCCAGATCACCGG
TGCGATACCAGGTGCGGCCGTCATGCTCGACGAAGCGCTCCGCGGTCAGCTCGGGACGGCCACGGTAACC
CCGGGCGATTCCGCGACCGGACACCCACAACTCACCGGCCACCCAATCGGGGCAGTCGTCGCCGCTGTCG
GCCACTACCCGGCAGGCGTTGTTGGGAAACGGGACGCCGTATGGCACCGAGGCCCAGTCCGGTGGCAGAT
TGGCCGCGTCCTGGACCTCGAAAATGGTTGCGTGGACCGCGGTTTCGGTGGCTCCACCCAACCCCGCGAA
CCGTGCGCTCGGCGCTTGCACCTGCAGGCGGCGGGCCAGGTCGGGACGCACCCAGTCGCCGCCGACGGCC
ACCGCTCGCAGCGACGACAGCCGGCCCCCGCCGACTTCGAGCAGCATGTCCAACCAGCCCGGCATGAAAT
TCAACGCCGTGACCTCGTAAGTGTCGATAAGCCGGGCCCAGGCGTCGGGATCGCGGCGCTGCGCTTCGTC
GACCACCACGATCGCTCCGCCGGAGCGCAGGGCGGCGAAGATGTCCAGCACCGACATGTCGCACTCCAGC
GTCGCCAGGGCAAGCCAGCGATCTGCGGCGCCTAGCTCGAAGTGCCGGATGAAGGTCTCCACGGTGTTCA
TCGCGGCGTCGTGCGCCACCTCGACACCCTTGGGTTCCCCGGTTGAGCCCGAGGTGAACAACACATAGGC
GAGCGCGGTGGGATCGCTAGGCCCGGGCACGAATTCTGCCGGCGCGGCGGCAAGCACGTCAGCCAGCAAC
AGCGTCGGGACCGGCACCCGCACTTGGCATGGCGGGCCGCAAACGAGCGCTAAGTTGACCGAACCGGTCG
CCAGGATGCGCTCCGCGCGGTCGCGGGGCTGGTCGACGCCGATCGGCAGATAGACCCCGCCGGCGGCCAA
AATCCCCAGCACAGCCGCCACTTGTTCGCCCGTTTTCGGACCCAGCACCGCGACGGTGTCGCCGACTCGT
AGGCCCGCAGCACGCAGCGCCGCGGCCACCGCCGATGCCTGGTCGCGCAGTTGGGCGTAGCTCAAGTCGC
CGGAACTGGCGAACACCGCCGGCGCGTCGGGCTGCTGTTGGGCCTGGCGGAAAAACCCGTCGTGCAGCGC
CTCGGTGCTGGGGGCGGCGGTGCGACCGTTCAGCGCCGCGCGCACCGCGCGTTGCGCGGCGGGTAGCGCG
GACGGGCTCGGCGCATCCCAGGCGTCGTCCCCGGCGGCCAACCGGAGCAATTCGTCGACCTGGTGGGTGA
ACATGGCGTCGATGACGCCGGGTGCAAAGACCCCCTCGCGGACATCCCAGTTCACCAGCACACCGCCGTC
GAACTCGGTGACCTGGGCGTCGAGCAGCACCTGGGGCCCCTGCGAAATGATCCATCCGGGTGTGCCGAAT
TGCTCGGTGACGTCCGGGCAGAAAAGGTCGCCGAGCCCCAGCGCGCTGGTGAATACCACCGGTGCCAGCA
CCTGGGTGCCACGGTGGCGGCTGAGGTCACGCAGCACAGACAGCCCGGGGTATGCACTGTGGCCTGCGGC
GCTGCGCAGGGCTTCCTGCACCGCCTGCGCCCGCGCCGCCGCCGTGCGCGCACCGGTCAGATCGACGTCG
AGCAACAGCGAGGAGGTGAAGTCACCGACCAGCAGGTCGACGTCTGGATGCAGGGCCTGGCGACTGAACA
ACGGCAGGTTCAGCAGGAACCGCGACGACGCTGACCAACGCGCCAGCACGTTGGCAAAGGCCGCGGCCAG
CGTCATCGCCGGGGTGATGCCGCGGGCCCGGGCTCGGGCGAACAACGCGTCGCGGGTCTGCGGGTCTAGC
CAGTGCCAGCGCCGGGTGCTGCGGCGCCGGTCGCGTTCGCCGCCGGCCCGGGTAGGCAGCGCGGGCGGAT
CCGGCAGCTGCGGGATGCGCTGCGCCCACCAGTCCCGGTCGGCGTCGCGAACCGGTTGGGGCAGCGTCTC
CTCCGCCTCGATAGCCTGCCGGTATTCCCGGTAGGTGTAGCCCAGTGCCGGCGGTTCACGGCCGTCATAG
AGGGCCGCCAGGTCGGCCAGCAAGATGCGGTAGCTCATCGCGTCAGCGGCCTGCATGTCCAGGTCGACAT
GTAGGCGGGTGCGCTCCCCCGGTAATAACGTCAACGCAAGTTCGAATACCGCACCGTCGAGCTGCTGGTG
CGATTTGGCGTCGCGGATCCCCGCCAACCGCTGATCGACGACATCCGGGGCCACGTGACGCAGGTCGGCA
ACACTGATGGGAAAGTCGCGAGATCCCGCCGCCGGCGGGATGCGCTGGGTGCCGTCGGGCAAGAACTGCA
CCCGCAGCATCGGGTGCCGCAGCGCCAACCGGGTGGCCGCCGCGCGGAGCCTGTCCGGATCGACCCGGGC
ACCATCGAACTCGACGTAGAGGTGCCCAGCTACCCCGCCGAGCTGTTGGTGGTCGTGGCGGCCGACCCAC
ATCGCGTGCTGCATCGGCGCCAGCGGGAAAGGCTCGCCTTCCTGGGATAACCCGGCATCCCCTGGTGCGG
CAACTGCCGTGGGCGCGACGCCGGTGCCGGCGGACACCAGTTGGGACCAGGCCTCGATTGTGGGTGTGGC
GGCCAGTGTGGCGAAGTCGACGGCGATGCCCTTCCGGCGCCAGCGCCCCACCAGCGACATCATCCGGATC
GAGTCCAGGCCCTGACCAACGAGGTTGGCGCCGGGGTGCAGAGCATCGGCGCGGACACCGAGCAACTCTG
CGACCTCGGCGCGAATGATCTCCGAGCACGCCGTAGCATGCACCA
Protein Sequence 
>gi|15609520|ref|NP_216899.1| phenyloxazoline synthase [Mycobacterium tuberculosis H37Rv] MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells (De et al., 2000).
COG COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
De et al., 2000: De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu Y, Barry CE 3rd. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(3); 1252-1257. [PubMed: 10655517].