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icl from Mycobacterium tuberculosis H37Rv

Victor ID 176
Gene Name icl from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886291
NCBI Protein GI 57116734
Locus Tag Rv0467
Protein Accession YP_177728.1
Other Database IDs UniProtKB-ID: ACEA_MYCTU
UniRef100: UniRef100_P0A5H4
UniRef90: UniRef90_P0A5H4
UniRef50: UniRef50_P08216
UniParc: UPI0000125205
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAE55284.1
EMBL-CDS: AAK44707.1
RefSeq_NT: NC_002755.2
RefSeq_NT: NC_000962.2
PDB: 1F61
PDB: 1F8I
PDB: 1F8M
EnsemblGenome: EBMYCG00000001780
EnsemblGenome_TRS: EBMYCT00000001782
EnsemblGenome_PRO: EBMYCP00000001782
EnsemblGenome: EBMYCG00000071118
EnsemblGenome_TRS: EBMYCT00000071123
EnsemblGenome_PRO: EBMYCP00000069182
GenomeRevi
Taxonomy ID 83332
Gene Starting Position 557526
Gene Ending Position 558812
Gene Strand (Orientation) +
Protein Name isocitrate lyase
DNA Sequence 
>gi|57116681:557526-558812 Mycobacterium tuberculosis H37Rv, complete genome
TATGTCTGTCGTCGGCACCCCGAAGAGCGCGGAGCAGATCCAGCAGGAATGGGACACGAACCCGCGCTGG
AAGGACGTCACCCGCACCTACTCCGCCGAGGACGTCGTCGCCCTCCAGGGCAGCGTGGTCGAGGAGCACA
CGCTGGCCCGCCGCGGTGCGGAGGTGCTGTGGGAGCAGCTGCACGACCTCGAGTGGGTCAACGCGCTGGG
CGCGCTGACCGGCAACATGGCCGTCCAGCAGGTGCGCGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGG
CAGGTCGCCGGCGATGCCAACCTGTCCGGGCACACCTACCCCGACCAGAGCCTGTATCCCGCCAACTCGG
TGCCGCAGGTGGTCCGCCGGATCAACAACGCACTGCAGCGCGCCGACCAGATCGCCAAGATCGAGGGCGA
TACTTCGGTGGAGAACTGGCTGGCGCCGATTGTCGCCGACGGCGAGGCCGGCTTTGGCGGCGCGCTCAAC
GTCTACGAGCTGCAGAAAGCCCTGATCGCCGCGGGCGTTGCGGGTTCGCACTGGGAGGACCAGTTGGCCT
CTGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTGTTGATCCCGACCCAGCAGCACATCCGCACTTTGAC
GTCTGCTCGGCTCGCGGCCGATGTGGCTGATGTTCCCACGGTGGTGATCGCCCGTACCGACGCCGAGGCG
GCCACGCTGATCACCTCCGACGTCGACGAGCGCGACCAGCCGTTCATCACCGGCGAGCGCACCCGGGAAG
GCTTCTACCGCACCAAGAACGGCATCGAGCCTTGCATCGCTCGGGCGAAGGCCTACGCCCCGTTCGCCGA
CTTGATCTGGATGGAGACCGGTACCCCGGACCTCGAGGCCGCCCGGCAGTTCTCCGAGGCGGTCAAGGCG
GAGTACCCGGACCAGATGCTGGCCTACAACTGCTCGCCATCGTTCAACTGGAAAAAGCACCTCGACGACG
CCACCATCGCCAAGTTCCAGAAGGAGCTGGCAGCCATGGGCTTCAAGTTCCAGTTCATCACGCTGGCCGG
CTTCCATGCGCTGAACTACTCGATGTTCGATCTGGCCTACGGCTACGCCCAGAACCAGATGAGCGCGTAT
GTCGAACTGCAGGAACGCGAGTTCGCCGCCGAAGAACGGGGCTACACCGCGACCAAGCACCAGCGCGAGG
TCGGCGCCGGCTACTTCGACCGGATTGCCACCACCGTGGACCCGAATTCGTCGACCACCGCGTTGACCGG
TTCCACCGAAGAGGGCCAGTTCCACTA
Protein Sequence 
>gi|57116734|ref|YP_177728.1| isocitrate lyase [Mycobacterium tuberculosis H37Rv] MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: icl mutant is attenuated in activated macrophages (McKinney et al., 2000).
COG COG2224C, under C: Energy production and conversion
References
McKinney et al., 2000: McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 2000; 406(6797); 735-738. [PubMed: 10963599].