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pepD from Mycobacterium tuberculosis H37Ra

Victor ID 1866
Gene Name pepD from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212589
NCBI Protein GI 148660764
Locus Tag MRA_0990
Protein Accession YP_001282287.1
Other Database IDs UniProtKB-ID: A5U125_MYCTA
UniRef100: UniRef100_A5U125
UniRef90: UniRef90_A5WL05
UniRef50: UniRef50_A4T6T7
UniParc: UPI0000031992
EMBL: CP000611
EMBL-CDS: ABQ72725.1
RefSeq_NT: NC_009525.1
MEROPS: S01.494
EnsemblGenome: EBMYCG00000066988.
EnsemblGenome_TRS: EBMYCT00000066993
EnsemblGenome_PRO: EBMYCP00000065103
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0990
eggNOG: COG0265
HOGENOM: HBG585708
OMA: TGPGPIP
ProtClustDB: CLSK790871
BioCyc: MTUB419947:MRA_0990-MONOMER
Taxonomy ID 419947
Gene Starting Position 1100373
Gene Ending Position 1101767
Gene Strand (Orientation) +
Protein Name serine protease PepD
DNA Sequence 
>gi|148659757:1100373-1101767 Mycobacterium tuberculosis H37Ra, complete genome
CATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGGAAGAGCAACCTAGCGACATGACGAATCACCCA
CGGTATTCGCCACCGCCGCAGCAGCCGGGAACCCCAGGTTATGCTCAGGGGCAGCAGCAAACGTACAGCC
AGCAGTTCGACTGGCGTTACCCACCGTCCCCGCCCCCGCAGCCAACCCAGTACCGTCAACCCTACGAGGC
GTTGGGTGGTACCCGGCCGGGTCTGATACCTGGCGTGATTCCGACCATGACGCCCCCTCCTGGGATGGTT
CGCCAACGCCCTCGTGCAGGCATGTTGGCCATCGGCGCGGTGACGATAGCGGTGGTGTCCGCCGGCATCG
GCGGCGCGGCCGCATCCCTGGTCGGGTTCAACCGGGCACCCGCCGGCCCCAGCGGCGGCCCAGTGGCTGC
CAGCGCGGCGCCAAGCATCCCCGCAGCAAACATGCCGCCGGGGTCGGTCGAACAGGTGGCGGCCAAGGTG
GTGCCCAGTGTCGTCATGTTGGAAACCGATCTGGGCCGCCAGTCGGAGGAGGGCTCCGGCATCATTCTGT
CTGCCGAGGGGCTGATCTTGACCAACAACCACGTGATCGCGGCGGCCGCCAAGCCTCCCCTGGGCAGTCC
GCCGCCGAAAACGACGGTAACCTTCTCTGACGGGCGGACCGCACCCTTCACGGTGGTGGGGGCTGACCCC
ACCAGTGATATCGCCGTCGTCCGTGTTCAGGGCGTCTCCGGGCTCACCCCGATCTCCCTGGGTTCCTCCT
CGGACCTGAGGGTCGGTCAGCCGGTGCTGGCGATCGGGTCGCCGCTCGGTTTGGAGGGCACCGTGACCAC
GGGGATCGTCAGCGCTCTCAACCGTCCAGTGTCGACGACCGGCGAGGCCGGCAACCAGAACACCGTGCTG
GACGCCATTCAGACCGACGCCGCGATCAACCCCGGTAACTCCGGGGGCGCGCTGGTGAACATGAACGCTC
AACTCGTCGGAGTCAACTCGGCCATTGCCACGCTGGGCGCGGACTCAGCCGATGCGCAGAGCGGCTCGAT
CGGTCTCGGTTTTGCGATTCCAGTCGACCAGGCCAAGCGCATCGCCGACGAGTTGATCAGCACCGGCAAG
GCGTCACATGCCTCCCTGGGTGTGCAGGTGACCAATGACAAAGACACCCTGGGCGCCAAGATCGTCGAAG
TAGTGGCCGGTGGTGCTGCCGCGAACGCTGGAGTGCCGAAGGGCGTCGTTGTCACCAAGGTCGACGACCG
CCCGATCAACAGCGCGGACGCGTTGGTTGCCGCCGTGCGGTCCAAAGCGCCGGGCGCCACGGTGGCGCTA
ACCTTTCAGGATCCCTCGGGCGGTAGCCGCACAGTGCAAGTCACCCTCGGCAAGGCGGAGCAGTG
Protein Sequence 
>gi|148660764|ref|YP_001282287.1| serine protease PepD [Mycobacterium tuberculosis H37Ra] MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pepD mutant has altered virulence in mouse model of infection (White et al., 2010).
COG COG0265O, under O: Posttranslational modification, protein turnover, chaperones
References
White et al., 2010: White MJ, He H, Penoske RM, Twining SS, Zahrt TC. PepD participates in the mycobacterial stress response mediated through MprAB and SigE. Journal of bacteriology. 2010; 192(6); 1498-1510. [PubMed: 20061478].