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mmaA3

Victor ID 285
Gene Name mmaA3
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888058
NCBI Protein GI 15607783
Locus Tag Rv0643c
Protein Accession NP_215157.1
Other Database IDs UniProtKB-ID: MMAA3_MYCTU
UniRef100: UniRef100_A5U028
UniRef90: UniRef90_A5U028
UniRef50: UniRef50_A5U027
UniParc: UPI00000D4706
EMBL: BX842574
EMBL-CDS: CAB07102.1
RefSeq_NT: NC_000962.2
HSSP: Q11195
EnsemblGenome: EBMYCG00000002550
EnsemblGenome_TRS: EBMYCT00000002552
EnsemblGenome_PRO: EBMYCP00000002552
GenomeReviews: AL123456_GR
TubercuList: Rv0643c
HOGENOM: HBG687502
ProtClustDB: CLSK790562
BioCyc: MetaCyc:RV0643C-MONOMER
Taxonomy ID 83332
Gene Starting Position 737267
Gene Ending Position 738148
Gene Strand (Orientation) -
Protein Name METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE)
DNA Sequence 
>gi|57116681:737267-738148 Mycobacterium tuberculosis H37Rv, complete genome
TCTACTTGGCCAGCGTGAACTGGTTGCAGTCGATGTAGCCCATTCGGAACGCCTTGGCGCAGCCGGTCAG
GTATTTCATGTACCGCTCGTATACCTCTGCGGACTGGATCTCGATGGCCTCGTCCTTGTGCGCTTGAAGC
GCCTCGGCCCACAGGTCAAGAGTCCTGGCGAAGTGCGGTTGCAGGGACTGGATATCGGTAATGGTGAAAC
CGGCCTTCGTCACATGCTCCTCGATCGTCTCGATCGTCGGCAACCGGCCGCCCGGGAAGATGTCGGTCAC
GATGAACCGGATGAATTTGGCCATCTCCATGGTCAACGGTATGCCGCGCTCGATGACCTGCTTTACGTGC
AAGCCGGTGATCGAGTGCAGCAGCATCACGCCGTCCGCGGGCATCGCGTTGTAGGCGAACTTGAAGAAGT
CATCGTAGCGCTCGAAACCGAAGTGCTCTATCGCTTCGATGGTTACGATGCGGTCCACCGGCTCGCTGAA
GTTGGCCCAGTCGCTCAGCAGTACCCGGTGCGAGCGGTTGGTGTCGACCTTGTCGAGCACTTGCTGGCAG
TAGGCGTGCTGATTTTTCGACAGGGTCAAGCCGACGACGTTGACGTCGTAGCGCTCGACGGCACGCTTCA
TGACCGAACCCCAGCCGCAGCCCACGTCGAGCAGTGTCATTCCCGGTTCTAGCCCCAGCTTGCCCAGGGT
TAGGTCCAGCTTGGCGACCTGTGCTTCGTGCAAGGTCATGTCGTCGCGCTCGAAGTAGGCGCAGCTGTAG
GTCCGAGTCGGATCCTGGAACAGCGCGAAGAACGCATCTGAAAGGTCGTAATGGGCTTGGACGTCGTCGA
CATTGGACCGAGACTTTGTGGTGCCCGTTGAGTTATCAGACA
Protein Sequence 
>gi|15607783|ref|NP_215157.1| methoxy mycolic acid synthase MmaA3 [Mycobacterium tuberculosis H37Rv] MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG2230M, under M: Cell wall/membrane/envelope biogenesis
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].