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Rv0386

Victor ID 140
Gene Name Rv0386
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886030
NCBI Protein GI 15607527
Locus Tag Rv0386
Protein Accession NP_214900.1
Other Database IDs UniProtKB-ID: O53720_MYCTU
UniRef100: UniRef100_A5TZB3
UniRef90: UniRef90_A5TZB3
UniRef50: UniRef50_Q10550
UniParc: UPI000016521A
EMBL: BX842573
EMBL-CDS: CAA17392.1
RefSeq_NT: NC_000962.2
HSSP: P10957
EnsemblGenome: EBMYCG00000002269.
EnsemblGenome_TRS: EBMYCT00000002271
EnsemblGenome_PRO: EBMYCP00000002271
GenomeReviews: AL123456_GR
KEGG: mtu:Rv0386
TubercuList: Rv0386
HOGENOM: HBG569441
ProtClustDB: CLSK790484
Taxonomy ID 83332
Gene Starting Position 463410
Gene Ending Position 466667
Gene Strand (Orientation) +
Protein Name PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY)
DNA Sequence 
>gi|57116681:463410-466667 Mycobacterium tuberculosis H37Rv, complete genome
GATGAGCAAGTTGCTGCCACGGGGCACAGTGACATTGCTGTTGGCCGACGTCGAGGGATCCACCTGGCTG
TGGGAGACCCATCCAGACGACATGGGTGCTGCCGTGGCGCGCCTCGACAAAGCCGTGTCTGGTGTGATTG
CCGCCCATGACGGCGTACGCCCAGTCGAGCAGGGTGAGGGTGATAGCTTTGTCCTCGCGTTCGCCTGCGC
GTCGGATGCCGTGGCCGCCGCGTTGGACTTGCAGCGAGCGCGGCTCGCACCGATCCGGTTGCGCATAGGC
GTGCACACCGGGGAGGTCGCGCTCCGCGACGAAGGCAACTATGCCGGTCCGACCATCAACCGGACCGCGC
GCCTGCGTGACTTGGCGCATGGGGGCCAGACGGTGCTCTCGGGCGTGACCGAAAGCCTGGTCATCGATCG
CCTCCCGGACAAAGCATGGCTGGTTGACCTGGGGACGCACGCGCTGCGGGATCTGTCGCGTCCGGAGCGG
GTAATGCAGCTGTGTCATCCCGAATTGCGTATCGATTTCCCGCCGCTGCGGGTGGCCAATGACGATGTGG
CCCATGGTCTTCCGGTGCACCTGACGCGTTTTGTGGGGCGCGGCGCGCAGATCACCGAGGTGCACCGGTT
GGTGACCGATAACCGGTTGGTGACCCTGACCGGCGCCGGCGGCGTGGGCAAGACACGGCTGGCGGCGCAG
CTCGCGGCGCAGATCGCCGGTGAGTTCGGTCGCGCGTGGTTCGTGGATCTGGCGCCGATCACGGACCCCG
ACTTGGTGCCGGTCACGGTGGCGGGCGCGCTGGGACTGCACGACCAGCCGGGCCGCTCCACGACGGACAC
CGTGCTGCGCTTTCTTGGCGGGCGTCCAGCCCTGGTGGTGCTGGATAACTGCGAGCACCTGCTGGATGCG
ACGGCGGCCTTGGTGTTAGCGCTGGTGAAAGCGTGCCGGGGGGTGAGGTTGCTGGCAACTTGTCGTGAGC
CGCTCCGGGTCGAGGGTGAGGTGAGCTACCGGGTGCCGTCGCTGTCACTGAGCGATGAAGCCGTTGAGAT
GTTTTGCTACCGGGCTCAGCGAGTCCGGCCGGACTTTCGCCTCACCGACGACAACTCCGCCGCAGTGACC
GAGATCTGCAAACGGCTGGACGGTTTGCCGCTGGCGATCGAGCTGGCGGCTGCGCGGCTGCGGTCGATGA
CGCTTGACGAGATCATCGATGGCTTGCGTGACCGGTTCGCGCTGTTGACCGGCGGTGCGCGCACGGCCGC
GCACCGGCAGCAGACGCTGTGGGCCTCGGTGGATTGGTCGTACACGCTATTGACCGAGCCGGAACGTACC
TTGTTTCGCCGGCTTGCGGTGTTTGTGGGTTGCTTTTTTGTCGACGACGCACAGGCGGTTGCCTGCAGCG
GCGATGTGCAGCGCTACCAGGTCCTTGACGAGATCACCCTGCTGGTCGACAAGTCACTGGTGATGGCCGA
CGACAACAGCGGCCGGACGTGCTATCGGTTATGCGAGACGATGCGCCACTACGCGTTGGAAAAACTCTCC
GAGGCTGGCGAGGTGGACGCCGTGTTTGCGCGGCACCGTGACTACTACACGGCGCTGGCTGCCAGGGTCG
ACAATCCCGGACCCTCCGATTATTCGCACTGCCTCGACCAAGCCGAAACCGAGATCGACAACCTACGTGC
CGCCTTTGTGTGGAACCGGGAAAATTCCGACACCGAGGGCGCCTTGGCGCTGGCGTCCTCCCTGTTGCGG
GTATGGATGACGCGGGGGCGCATCCAGGAGGGGCGCGCCTGGTTTGACAGCATTCTTGCCGACGAGAATG
CGCGTCATCTCGAGGTGGCGGCCGCGGTGCGCGCCCGGGCATTGGCCGACAAGGCCCTGCTCGACATCTT
CGTCGACGCCGCCGCCGGTATGGAGCAGGCCCAACAGGCTTTGGTGATCGCGCGCGAGGTCGATGAACCG
GCGCTGCTGTCCCGGGCGCTCACGGCCTGCGGCTTGATCGCGGTAGCGGTAGCTCGCGCCGATGCGGCCG
CGTCTTATTTCGCCGAGGCGATCGACCTGGCACGAGCGGTAGACGACCGGTGGAGGCTGGCCCAGATCCT
TACCTTTCAGGCGGTCGATGCGGTCGTGGCGGGTGACCCGGTCGCGGCACGCCCGGCCGCCCAAGAGGCA
CGCGAGCTGGCTGCCGCGATCGGTGACCACTCCAATGCGCTGTGGTGCCGCTGGTGTCTCGGCTACGCCC
AGCTGATGCGGGGGGAGCTGGCCGCGGCCGCCGCCCAATTCGGCGAGGTGGTGGACGAGGCCGAGGCGTC
TCAGGAAGTGCTGCACAAGGCCAACAGCCTGCAGGGCCTGGCCTTCGCGCTCGCCTACCAGGGTGAATTG
AGTGCGGCTAGGGCGGCGGCCGACGCCGCTCTCGAGGCCGCCGAGCTGGGCGAGTACTTCGCGGGTATGG
GCTACTCGGCGTTGACCACGGCCGCGTTGGCCGCCGGCGACGTGCAGACGGCTCAACATGCCAGCGAGGC
GGCCTGGCGGAACTTGAGTTTGGCGCTGCCCCTCTCGGCAGCGGTGCAGCGCGCGTTCAATGCCCAGGCT
GCACTGGCTGGTGGTGACCTTAGCGCAGCGCGTCGTTGGTGTGACGATGCCGTGCAGTCAATGACCGGCC
ATCATCTGGCGATGGCGCTGGCGACTCGCGCCAGGATCGCGGTCGCCGAGGGCAAGCGGGAAGAAGCCGA
ACGCGACGCGCATAAGGCGCTCGCGTGCGCGGCCGAGAGCGGGGCACACCTGGATCTCCCCGACGTGCTC
GAATGCCTTGCCGGCCTGGCCAGCGACGCCGGCACCCACCATGCGGCGGCACGACTCTTCGGCGCCGCCG
AGGCTATCCGACAGCAGATCGGCTCGGTCCGCTTCGCGATTTACCGTTCGGACTATGTGCAGTCGGTGAC
GGCTCTGCGAGATGCGATGGGGGAGAAAGACTTCGACGCTGCATGGGCCGAAGGTGCCGCGTTGTCGATC
AAGGAGACGATCGCCTATGCGCAACGTGGCCACTCCTGGCGCAAACGACCGGCCACCGGTTGGGAATCGC
TTACTCCGACCGAGATTGACGTCGTGCGACTGGTTGGCGAGGGACTGGCCAACAAGGACATCGCGACGCG
GCTTTTCGTCTCACCGCGAACAGTGCAAACGCACCTGACGCACGTCTACACCAAACTCGGCTTCACCTCG
CGACTGCAACTCGCTCAAGCGGCCGCCCGCCGTACCTG
Protein Sequence 
>gi|15607527|ref|NP_214900.1| transcriptional regulator [Mycobacterium tuberculosis H37Rv] MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGVIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Rv0386 mutant is attenuated in mice (Paige and Bishai, 2010).
COG COG3903R, under R: General function prediction only
References
Paige and Bishai, 2010: Paige C, Bishai WR. Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view. Cellular microbiology. 2010; 12(3); 301-309. [PubMed: 20039878].