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plcA from Mycobacterium tuberculosis H37Rv

Victor ID 134
Gene Name plcA from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885995
NCBI Protein GI 15609488
Locus Tag Rv2351c
Protein Accession NP_216867.1
Other Database IDs UniProtKB-ID: PHLA_MYCTU
UniRef100: UniRef100_Q04001
UniRef90: UniRef90_Q04001
UniRef50: UniRef50_P95246
UniParc: UPI0000131976
EMBL: L11868
EMBL: U49511
EMBL: BX842579
EMBL: AE000516
EMBL: M57952
EMBL: S69737
EMBL-CDS: AAB59164.1
EMBL-CDS: AAB59165.1
EMBL-CDS: AAC18943.1
EMBL-CDS: CAB06148.1
EMBL-CDS: AAK46709.1
EMBL-CDS: AAA63288.1
EMBL-CDS: AAC60465.2
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000002237
EnsemblGenome_TRS: EBMYCT00000002239
EnsemblGenome_PRO: EBMYCP00
Taxonomy ID 83332
Gene Starting Position 2630536
Gene Ending Position 2632074
Gene Strand (Orientation) -
Protein Name PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA (MTP40 ANTIGEN)
DNA Sequence 
>gi|57116681:2630536-2632074 Mycobacterium tuberculosis H37Rv, complete genome
TTCAGCTGCACAGCCCGCTGGGAGTCCCGCGGACGGGTGTGGTTTCCTGAGTTGGCATCACCTGCGGATA
GGGCACCCGATAGGGAATGCTCGGCAACGCGCCGTCGGTGGTTCCCAACACCACGTTAGGGATGCACTGC
GGCAGCTTCGGCAGCGCTCCCAGCAACGGGTGGCTCAAGTTGGGTCTGGTCGAATTCGGTGGAGTCGCAA
AGTTGAACGCTGAGGTCATGTCGCCAACCACGCCGTCGCGCCAGGCGGTCATGTTGGGAACCGGCACGCC
GAACCGGGCGCGAATCAACTTCAATTGCGAGGTGTGGTCGAACGTGTCGGAGACCATCAGCGGGCCGCGG
CTGTACGGCGAAATGACAATGCAGGGAACGCGAAAACCCAGACCGAGCGGACCACGAATGCCACCGGACC
CGGGTACTGCGTCGATGTTGGGCACCGTGACGAATTCGCCGGGTGTCCCGGGCGGTGCCGTGGGGGGCGT
GACGTGGTCGAAGAAGCCGCCGTTCTCGTCATAGCTGACGATAAGTGCGGTCTTTTCCCACACCGCGGGA
TTGGACAGCAAGATCCGCAGCGCGGTCACCATGGACACCGCGCCAAGCGCTACCGGCAGGGCGGGGTGTT
CGGACTGCAGGATGTTGGGAACTAACCAGGAGACCTTGGGTAGCCGGTTGGCCCTGACGTCGGCAGCGAA
GTCCCCAGGGTAGGTCGGGGCGATACCGTAGCGGGCCAAGTTCGACCTCGGATCAGCTGCCTGGCGGAAG
GCCTGCACCAGCCCGTTATTGCTGATGGGCGTGTTGATGAATCGCCCGAGGCCCTTGTTCTGGTACACCT
TCCAGCTGACCCCGGCATCTTCGAGGTTTTCCGGCATGATGCGCCAACTGAATTGCTGCAGCGGCAGGAA
GCCCGGCTCTACCAATTGGGGTCCCCCGTCGGTGCCGGCGGGGTCGATGTTGGCGCTCAACCAGTAGAGC
CGGTTGGGCAGGGTGCCCGTCAGCAGCGAGCAATGGTAGCCGTCGCAGATGGTGAACGTGTCGGCCAGCA
GATAGTGGATCGGGATGTCTTGGCGCGTGTAGTAACCCATGGTCAAAGGGACATATGGTCCTGCGCGGGT
GGTCGCCTGCGCCGGCAGCCAGTTGTCGTTGGCACCACCGTTCCAGGCCAGGTGCATCCCCACCCACTGG
TGCTCGGGGTCGTTGACGCACTCGCCGTCCAGGAAGGGGCCTCGGGTGGTGTCCAAGCGGAACGGAATGG
TGACCCCGGCGGGGTCCAACGCCTGCGTCATGGGGTTCCAACCCATTTGTTGGAATGCCGGCGACGCGGC
GTTGAACCCATTGGTGCTGGAAAGCGTTCCGAAATAGTGGTCGAATGACCGGTTCTCCTGCATCAGCAAC
ACGATATGCTCGATGTCGGTCAAATGTCCGGGACAAGGCCCGGCGCCGTAGGCCTTTTCAATCACCGGTG
CAGCCCAGTCCATCAGGAATGCCGCTGCGCCTGCGCCAGTGAGCTTTGTCAAAAACTCTCGACGTGACA
Protein Sequence 
>gi|15609488|ref|NP_216867.1| membrane-associated phospholipase A [Mycobacterium tuberculosis H37Rv] MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQALDPAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATTRAGPYVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIMPENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDFAADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKTALIVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVGDMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIPYRVPYPQVMPTQETTPVRGTPSGLCS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002).
COG COG3511M, under M: Cell wall/membrane/envelope biogenesis
References
Raynaud et al., 2002: Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelicic V, Manganelli R, Smith I, Gicquel B, Jackson M. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Molecular microbiology. 2002; 45(1); 203-217. [PubMed: 12100560].