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mmpL8 from Mycobacterium tuberculosis H37Ra

Victor ID 1897
Gene Name mmpL8 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214944
NCBI Protein GI 148663691
Locus Tag MRA_3863
Protein Accession YP_001285214.1
Other Database IDs UniProtKB-ID: MMPL8_MYCTA
UniRef100: UniRef100_A5U9F2
UniRef90: UniRef90_A1KQF8
UniRef50: UniRef50_A5U9F2
UniParc: UPI000012F274
EMBL: CP000611
EMBL-CDS: ABQ75652.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000068130
EnsemblGenome_TRS: EBMYCT00000068135
EnsemblGenome_PRO: EBMYCP00000066245
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3863
eggNOG: COG2409
HOGENOM: HBG567289
OMA: TKPELAN
ProtClustDB: CLSK792742
BioCyc: MTUB419947:MRA_3863-MONOMER
Taxonomy ID 419947
Gene Starting Position 4296705
Gene Ending Position 4299974
Gene Strand (Orientation) -
Protein Name transmembrane transport protein MmpL8
DNA Sequence 
>gi|148659757:4296705-4299974 Mycobacterium tuberculosis H37Ra, complete genome
CCTAAAGCCTGAGCCCGTCGTGTAACCAAAGACCGATCAGATCGTCGTCGTCGGGCGGTGATTGCTCTTC
TTCTTCCTTGGGCAACAACGGCTTACGTTTGGTTCGTTGGGCACGGCCACGGCGTCGGCCAAGGGGCCAC
CAGGTTGCCGGCCGCCAGCTTGACGGCAACCACCAGTTCGCCTGCCCAACCAACACGGCAATGGCGGGCA
CGGTAACGGTACGCACCAAGAAGGTATCCAGCAAAAGCCCGGTCCCTAGGACGAACGCACCTTGAACCAC
GCTACCCAAGCTGGCGAATACCAGACCGTACATCGAGGCAGCCATGATCAAACCCGCCGCAGTGATCACA
CCACCTGTTGAGGCCACGGTCCGGATGACACCGGAACGCACCCCCAAGACGGCCTCTTCACGCAGCCTAG
AAATAAGCAGCATATTGTAATCTGCGCCCACCGCGACCAATATAACGAAGGTCAATCCCGGAATGCTCCA
ATGCATTTCCTGACCGAGTAAAAATTGGAACACGATAACGCCAATACCGAGCGCCGCCAGGTACGATACG
ATAACCGAGCCGATCAGATACAGCGGTGCCACAATCGCACGCAGCAAAACGATCAATATGAGCAGAACGA
TGCAGACGGTCATGGCGATGATCAATCGGAGGTCGTGATCGGAGTAGTCGCGCGTGTCCTTGAGAACGAC
GGGCAATCCGACGACAGACACCTTGGCATCGGCCAGTGCGGTATTTGGTTGCGCCCCTCGAGCGGCCGCC
GTGATCGCGTCAATTTGGTCCATGGCAGCAGTGCTGAATGGATTCAGGTCGGTTTGTATCAAATACCGTA
TTGAGTGGCCGTCGGGTGAAATGAAGGCCGCCGCGACTTTTTTGAGTTGGTCTACATTCAGCCCGCCTAG
CAGATCCCGATACTCTGACGGCATCGTCTCGGCTTTGACGCTCTCACCGGTGGCATACGACAACAACTCC
GGGGGAATATAGAACCCCGCCATCGCCGGCGTGGTCGCGGTGTCCTTCATTGCCAATAGGAACGCCGAGG
CCTCGCCCAACCCGAAACCCATCTTCTTCACCTGGTCGACCAACAACTGCACGCCCTCAGCCAGTTGCCG
GCTCCCGTCGGCGAGATCATTGACCCCCTTGTTCACCAGGTTGATCTTGGATCGCACACCACCAGGACTG
CTCATCCCCAGTGAACCCATCGCCCTGATGACGGTGGCCAGCGCCCCGCGTAATCCGGACACGGTGGCTG
CCAGGGTCTGCACTGCGCGCGTGGCCTGCAGCTGTCGAGCCAACTCAGATATCTTTGCCAGCGTTCCGTC
GTCGCGCGCTGTGACCAAACGCTGCAGTTCGGTGCGCGCACTGGCACAAGCCGGATCGGCAGTGCACATC
GGGCTGCTATCCAGCGCCCCCAGCACCGGGCTTGCCCACTCGGTGTTGTTCGCTACAAAGCTCGCATCCG
CGTCAATGGTGTCACCGAGTGCCCGCATGCTGCCGATCAGCTTCTCCGCGCCTTCCAGTTCGCCGAGAAC
CCTGTTGCCCCCGAGCAGGTCCTGAAGGTACGCCAGCGCGTCGATGAGGCCGCCGACCGTGGATATGGCC
CGGTTAACTTGGGCCCGTACGTCGCCGAGTTTGCTCGCCATCAGGTTGGCTCCACCGGCCAGTTTGTCGA
TGTCGCCGGTGTGCACAGCGATCTGCTTGGAACCCTCATCCAGCTTGCTGCCGACTTCGCCAGCCTGCCA
GGACGTCCGGGCCTGCTCCAGCGACCGTCCAGCGGGTCGGGTAATGCCCCTGACCATCGCGACACCCGGC
ACTTGGCTCACCCGCTGCACCATCTGCTCTAGGTCGGCGAGAGCCTTCGGCGTGCGCAGATCCGTCGAGG
ATTGGATGAACAGGTACTCGGGAATGATCAGGTTAGACGGGAAATGCTTGTCCAACGCGGCATACCCGAT
CGAACTCTCGACGGAAGCCGGAAGCGTCTTGCGATCGTCGTAGTTGTACCGGGCCAGTCCTGCGCAGCCG
GCCAGAATAACCAGCACCAGCGCGCTGGCGAGCAGATGAGTCTTGGGCCGACGCACGATGTGCACCCCCG
AACTCCGCCAAAAGCGCCGGGTGAGGTCACGGCGCGGCGCGATCCAACCGCGACGCCCGGTCAGCACCAT
CAGGGCGGGTAGCAGTGTGACAGCTGCGAAGAAGACCACGGCTACCGAGATTCCCAACATCGGACCAACC
GTTTTGAGAATTCCCAGTTGGGTAAACACCATCCCGAGAAAGGTGATTGCTACGGTAGCCGCGGAGGCGG
CGATCACCTTACCGATGGATGTCAATGCCTTCTTGACGGCTTGATCCGAATCCGCGCCCTGCCGTAAATA
GTCGTGATATCGACTAATCAGAAATACCGCGTAATCCGTTCCCGCACCGACCATCATCCCGCTCATAAAA
ATAATGCTCTGGTTAGCAATACCGAGGCCCGCCAAGCCGGCTATTGCAACGAGGCGCTGTGCAACCACCA
CGGACATGCCAATTGTTATCAATGGCAACACCATGGTGATCGGATTCCCGTAGATGATCAGCAAAATGAC
CAACAACAGGATCGTGATCGCAAACTCGATGCGACTGCGGTCCCGTTGCCCGGTGAGGTTCAGATCGGCG
ACGGTGGCCGCGGGCCCGGTCAGGTTAGCCGTCAGTGTCGAGCCTGCGACCTGGTGTTCGACGATGTCAG
CGACGCGGGCGTACGCCTGCTTGGACTGGGTCGAACCCAGGTCGCCGGGAAGGCCGACCGGCAGGATCCA
GGCCTGATTGTCTTTGCTGGTCATGAGCTCCCGCAGGGGCGGTGTGGTGACGAAGTCCTGGAGCATCACG
ACGTCTCGAGTATCGCGTCGCAGGGCGTCAACCAGCTCTTTGTAGCTGCGTTCATCGGCCGCGCCGAGCC
CTTTGGCATCGCTGAGCACCACCACCGCAACGCTCTGCAACCCGGCTTCACGAAATGCCGCGGTCATCTG
CCGGGTCGAGACCAACACCGGGGCGTCCGATGGCAGAATCGCCACTGGATGCCGCTGGGAGATCGCGTCC
AGGGACGGCACCGTCGGCGCAAGCAGACCCGCAAGCGCGACCCAGAAGGCGATCACCACCCACGGCCTTC
GGACGATAAGGCGCCCTAGCCGCGGAAAGACACCCCCGTCACCGGTTGGCCTAAGCGGTTTCGATCGTAA
GTTCGTCGAGGGTCTCGGTGTTCTGACAGGCTGCATCAAGACGTCGCACA
Protein Sequence 
>gi|148663691|ref|YP_001285214.1| transmembrane transport protein MmpL8 [Mycobacterium tuberculosis H37Ra] MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLRL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mmpL8 mutant is attenuated in mice (Converse et al., 2003).
COG COG2409R, under R: General function prediction only
References
Converse et al., 2003: Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, Cox JS. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(10); 6121-6126. [PubMed: 12724526].