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proS

Victor ID 321
Gene Name proS
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888539
NCBI Protein GI 15609982
Locus Tag Rv2845c
Protein Accession NP_217361.1
Other Database IDs UniProtKB-ID: SYP_MYCTU
UniRef100: UniRef100_O05814
UniRef90: UniRef90_A1KMI8
UniRef50: UniRef50_A8LYE7
UniParc: UPI0000136611
EMBL: BX842581
EMBL: AE000516
EMBL-CDS: CAB08445.1
EMBL-CDS: AAK47237.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000002622
EnsemblGenome_TRS: EBMYCT00000002624
EnsemblGenome_PRO: EBMYCP00000002624
EnsemblGenome: EBMYCG00000069283
EnsemblGenome_TRS: EBMYCT00000069288
EnsemblGenome_PRO: EBMYCP00000067347
GenomeReviews: AE000516_GR
GenomeReviews:
Taxonomy ID 83332
Gene Starting Position 3151201
Gene Ending Position 3152949
Gene Strand (Orientation) -
Protein Name prolyl-tRNA synthetase
DNA Sequence 
>gi|57116681:3151201-3152949 Mycobacterium tuberculosis H37Rv, complete genome
GCTACCCGGTGACGGCCGCTGCGATATCGGTGGCCAGCGAGGCGCCGGCAACCAGCTCGCGAGTCTGACC
GCTGAACCGGTCGCGCAGCTCGACCACGCCGTCCGCCCAGCCGCGCCCCACGACAACGATCCAGGGCATA
CCCAACAGCTCGGCATCTTTGAACTTGACGCCGGGCGATGCCTGGCGGTCGTCCAGCAACACCTCAACCC
CCAGCCGATCCAGATCGGCGGCCAGCGCGGTCGCCCCGGCGCGAGCCTGCGCGTCCTTGTTCGCGATCAC
CAGGTGAACATCGAACGGCGCGACCGTCGACGGCCAGCGAAGGCCCAGCTCGTCGTGGTGCTGCTCGGCA
ACGACGGCAACCAACCGAGACACACCGATGCCGTAGGAACCCATGGTCAACCGCACAGGCTTGCCATCCT
CGCCGAGCACGTCGGCGGTGAAGGCGTCGGTGTATTTGCTCCCCAGCTGGAAGATGTGCCCAATTTCGAT
ACCGCGCGCCATGACCAGCGGACCGGCGCCGTCGGGAGATGGATCGCCTTCGCGCACCTCGGCGGCCTCA
ATGGTGCCGTCTGCGGTGAAGTCGCGGCCGGCCACCAAACCGACAACATGGCGGCCGGGTTGGTCCGCCC
CGGTGATCCAGCTGGTGCCGTCGACTATCCGCGGGTCGACGAGATAGCGGACATTGTTCTCCCGCAACGC
CTTTGGCCCGATATAACCCTTAACCAGGAACGGGTGCTTGGCGAAATCATCGTCGTCGAGCAACGCGTAG
TCAGCCGGTTCCAGCGCTGCGCCCAACCTTTTGTCATCGACCTCACGGTCGCCGGGCACGCCGATTGCCA
GCAGTTCGGTGTCCCCTCCCGGCTGTCGGACTTTGATTAAGACGTTCTTCAGGGTGTCCGCGGCGGTCAC
CGTGCGGCCGAGATCGGCCTCGTTGGCCCAGGCCACCAGGCTGGCGATGGTTGGGGTGTCGCCGGTGTCG
TGGACCACCGCCTCGGGCAGCCCATCGATGGGCAGGGTGTCCGGGCGGGCGGTGACAACCGCCTCGACGT
TGGCCGCATAACCCGACTCGAGGCACCGGACAAATGCGTCCTCCCCGGACGGACTCTCAGCCAAGAACTC
TTCGGACGCACTGCCGCCCATCGCCCCGGACACTGCCGAAACGATGACATAGCGCACCTGAAGTCGGTCA
AATATGCGCTGGTAGGCCTCCCGGTGAGCGTGGTAGGCCGCCTTCAGCCCGGCGGCGTCGATGTCAAAGG
AGTAGGAGTCCTTCATGACGAACTCCCGAGCGCGCAGGATGCCGGCCCGCGGCCGCGCCTCGTCGCGGTA
CTTGGTCTGGATTTGGTACAGCGTGAGCGGGAAGTCCTTGTAGGAGCTGTACTCGCCCTTCACGGTCAGG
GTGAACAGCTCTTCGTGGGTGGGGCCCAGCAGGTAGTCGTTGCCGCGGCGGTCCTTGAGCCGAAACACGC
TGTCGCCGTATTGGGTCCACCGGTTGGTCGTCTCGTACGGTGCCCGCGGCAGCAGGGCAGGAAATAGGAT
CTCCTGTCCACCGATGGCGTTCATCTCGTCGCGGATGACCCGTTCTATGTTGCGCAGCACTCGCAGGCCG
AGCGGTAACCAGCTGTACAGCCCGGGCGCGACGGGCCGGATGTAGCCGGCCCGGATCAGCAGTTTGTGGC
TGGCCACTTCGGCGTCGGCGGGATCGTCGCGCAGGGTGCGCAAGAACAACTCGGACATCCGGGTGATCA
Protein Sequence 
>gi|15609982|ref|NP_217361.1| proline--tRNA ligase [Mycobacterium tuberculosis H37Rv] MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWLPLGLRVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRRGNDYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTVTAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHPFLVKGYIGPKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTRELVAGASLATDIAAAVTG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG0442J, under J: Translation, ribosomal structure and biogenesis
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].