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cysH from Mycobacterium tuberculosis H37Rv

Victor ID 91
Gene Name cysH from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885250
NCBI Protein GI 15609529
Locus Tag Rv2392
Protein Accession NP_216908.1
Other Database IDs UniProtKB-ID: CYSH_MYCTU
UniRef100: UniRef100_A1KL82
UniRef90: UniRef90_A1KL82
UniRef50: UniRef50_A1KL82
UniParc: UPI0000128CEC
EMBL: BX842579
EMBL: AE000516
EMBL-CDS: CAB03733.1
EMBL-CDS: AAK46757.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000003342
EnsemblGenome_TRS: EBMYCT00000003344
EnsemblGenome_PRO: EBMYCP00000003344
EnsemblGenome: EBMYCG00000069153
EnsemblGenome_TRS: EBMYCT00000069158
EnsemblGenome_PRO: EBMYCP00000067217
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 2686366
Gene Ending Position 2687130
Gene Strand (Orientation) +
Protein Name phosphoadenosine phosphosulfate reductase
DNA Sequence 
>gi|57116681:2686366-2687130 Mycobacterium tuberculosis H37Rv, complete genome
GATGAGCGGCGAGACAACCAGGCTGACCGAACCGCAACTACGTGAGCTGGCCGCGCGCGGAGCTGCCGAA
CTCGACGGCGCCACCGCCACCGACATGTTGCGCTGGACCGACGAAACCTTCGGCGACATCGGCGGCGCCG
GCGGCGGCGTGAGCGGACATCGCGGGTGGACAACGTGCAACTACGTAGTTGCTTCCAACATGGCTGATGC
GGTGCTGGTGGATCTGGCCGCCAAGGTGCGACCGGGCGTACCGGTCATCTTTCTTGATACCGGCTACCAC
TTCGTCGAAACAATCGGCACCAGAGATGCGATCGAGTCCGTCTATGACGTCCGGGTGCTCAATGTCACTC
CGGAGCACACAGTGGCCGAGCAGGACGAACTGCTGGGCAAGGACTTGTTCGCCCGCAACCCCCATGAATG
CTGCCGGTTGCGCAAGGTCGTTCCCCTGGGCAAGACGCTGCGTGGCTACTCCGCGTGGGTGACCGGGCTA
CGGCGGGTCGATGCACCGACCCGGGCCAATGCCCCGCTGGTCAGCTTCGATGAGACGTTCAAACTAGTGA
AGGTCAACCCGCTGGCGGCGTGGACCGACCAAGATGTGCAGGAATACATTGCCGACAACGACGTGCTGGT
TAATCCGCTTGTGCGGGAAGGCTATCCGTCGATCGGTTGCGCTCCGTGCACAGCCAAACCCGCCGAAGGC
GCCGACCCGCGCAGCGGACGCTGGCAGGGGCTGGCCAAGACCGAATGCGGGTTGCACGCCTCGTG
Protein Sequence 
>gi|15609529|ref|NP_216908.1| phosphoadenosine phosphosulfate reductase [Mycobacterium tuberculosis H37Rv] MSGETTRLTEPQLRELAARGAAELDGATATDMLRWTDETFGDIGGAGGGVSGHRGWTTCNYVVASNMADAVLVDLAAKVRPGVPVIFLDTGYHFVETIGTRDAIESVYDVRVLNVTPEHTVAEQDELLGKDLFARNPHECCRLRKVVPLGKTLRGYSAWVTGLRRVDAPTRANAPLVSFDETFKLVKVNPLAAWTDQDVQEYIADNDVLVNPLVREGYPSIGCAPCTAKPAEGADPRSGRWQGLAKTECGLHAS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cysH mutants are attenuated in mice (Senaratne et al., 2006).
COG COG0175EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Senaratne et al., 2006: Senaratne RH, De Silva AD, Williams SJ, Mougous JD, Reader JR, Zhang T, Chan S, Sidders B, Lee DH, Chan J, Bertozzi CR, Riley LW. 5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice. Molecular microbiology. 2006; 59(6); 1744-1753. [PubMed: 16553880].