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relA from Mycobacterium tuberculosis H37Rv

Victor ID 272
Gene Name relA from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887888
NCBI Protein GI 15609720
Locus Tag Rv2583c
Protein Accession NP_217099.1
Other Database IDs UniProtKB-ID: RELA_MYCTU
UniRef100: UniRef100_P66014
UniRef90: UniRef90_P66014
UniRef50: UniRef50_P66014
UniParc: UPI00019020F2
EMBL: BX842580
EMBL: AE000516
EMBL-CDS: CAB01260.1
EMBL-CDS: AAK46973.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000003204
EnsemblGenome_TRS: EBMYCT00000003206
EnsemblGenome_PRO: EBMYCP00000003206
EnsemblGenome: EBMYCG00000071170
EnsemblGenome_TRS: EBMYCT00000071175
EnsemblGenome_PRO: EBMYCP00000069234
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 2907825
Gene Ending Position 2910197
Gene Strand (Orientation) -
Protein Name PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE)
DNA Sequence 
>gi|57116681:2907825-2910197 Mycobacterium tuberculosis H37Rv, complete genome
GCTACGCGGCCGAGGTCACCCGGTAGACGTCGTAGACACCTTCGACGTTGCGGACGGCGTTGAGCAGGTG
CCCGAGGTGCTTGGGGTCACCCATCTCGAAGGTGAATCGACTGATCGCCACCCGGTCCCCCGAAGTGGTG
ACCGACGCGGACAGGATATTGACCTTCTCGTCGGCCAGTGCGCGCGTCACATCCGACAGCAGCCGGTGCC
GGTCGAGTGCCTCGACCTGGATTGCCACCAGAAACACCGACGACGGCGACGGCGCCCATAGCACCTCGAT
GATGCGCTCGGCCTGCTGCTGCAGCGATGCGGCGTTGGTGCAGTCGGTGCGGTGCACACTGACCCCGCCG
CCACGGGTGACGAACCCCATAATCACATCGCCCGGAACCGGCGTGCAGCACTTGGCCAGCTTGGTCAGCA
CGCCCGGGGCGCCGGGGACGGAGACCCCGACATCGTCGGTGCTGCGTGGGCGCCGCGGCATGGTCGCCGG
CGTGGACCGCTCGGCGAGTTCCTCTTCCGCCTGGTCGATACCGCCGAGCTCGGCCAACAACCGCTGCACG
ACGTGTTTCGCCGACACGTGCCCCTCACCGATGGCGGTATAGAGTGCTGACACGTCCGCGTAGTGCAGCT
CGCGGGCCACCGCCGCCATGGACTCACCATTGACCAAGCGCTGCAACGGAAGTCCACCGCGGCGCACCTC
GCGGGCCATCGCATCCTTACCGGTCTCCAACGCCTCCTCACGCCGCTCCTTGGCGAACCACTGGCGGATC
TTCGTCTTTGCGCGCGGCGACACCACGAACTGCTGCCAGTCCCGCGACGGCCCGGCGTTCGGCGCCTTGG
ACGTGAAAACCTCGACAACTTCTCCGTTTTCCAGCTTGCGTTCCAGCGCTACCAACCGGCCGTTCACTCG
GGCGCCGATGCAGCGGTGGCCCACCTCTGTGTGCACCGCGTAAGCGAAGTCCACCGGCGTCGAACCGGTT
GGCAGCGTGATCACGTCGCCCTTGGGGGTAAACACGAAAATCTCTTGCACCGCAAGGTCGTAGCGCAATG
ATTCCAAGAACTCACCGGGGTCGGCCGCCTCACGTTGCCAGTCGAGCAGCTGACGCATCCAGGCCATGTC
GTCGATCTCCGCGGCGGCATGCGGATGAAGAACACCGTTGCGGCCCTTGGCTTCTTTGTAGCGCCAATGC
GCGGCGATGCCGTATTCGGCGGTGCGGTGCATGTCGCGGGTACGGATCTGCACTTCCAGCGGCTTGCCCT
CAGGCCCGACCACAGTGGTGTGCAGTGACTGGTACACACCGTATCTGGGCTGGGCGATGTAGTCCTTGAA
CCGACCCGCCATCGGCTGCCATAGCGAATGCACTACGCCGACAGCCGCGTAGCAGTCCCGGATTTCGTCG
CACAGGATGCGCACACCGACCAGGTCGTGGATGTCGTCGAAGTCGCGGCCCTTAACGATCATCTTCTGGT
AGATCGACCAATAGTGCTTGGGGCGGCCCTCCACCGTCGCCTTGATCTTCGACGCGGTCAGCGTGTTGAC
GATTTCGGCACGCACCTTGGCCAGGTAGGTGTCCCGGGACGGCGCGCGACCGGCGACCAGCCGGACGATC
TCCTCGTACTTCTTGGGATGCAGGATCGCGAAGGACAGGTCCTCCAACTCCCACTTGACGCTGGCCATGC
CCAGCCGATGCGCCAGGGGTGCAATGACTTCCAACGTCTCACGGGCCTTGCGGGCCTGCTTCTCCGGCGG
CAAGAAGCGCATGGTGCGCATGTTGTGTAACCGGTCAGCCACCTTTATCACCAGCACCCGCGGATCGCGG
GCCATCGCGGTGATCATCTTGCGAATAGTCTCGCCTTCGGCGGCGCTGCCCAACACCACCCGATCCAGCT
TGGTCACCCCGTCGACGAGATGGCCCACCTCTTCGCCGAATTCCTCGGTCAACGCCTCCAGGGTGTAACC
GGTGTCCTCGACGGTGTCGTGCAGCAGCGCGGCCACCAAAGTGGTGGTGTCCATGCCCAACTCGGCCAGA
ATGTTGGCAACGGCCAACGGGTGGGTGATGTAGGGATCACCGGACTGCCGCAACTGGCTGGCATGCCTTT
GGTCAGCGACCTCGTAGGCTCGCTGCAAGATCGACAGGTCGGCCTTGGGATAGATCTCCCGGTGCACCGC
CACCAACGGCTCGAGCACCGGATTGGTGGTGCTGCGCTGGGCGGTCATCCGCCGGGCCAATCGGGCCCGC
ACCCGACGCGACGCGCTGATGCTGGTCTTAAGAGTCTCGACCGGCGACTCGGGCGTCTCGAGAGCGGGCT
CGAGAGCCGCAGAAGCCTCCGTGGGCGGTGCAACCGCTTGCGCCGTGAGCTGGTCCTCGGCCA
Protein Sequence 
>gi|15609720|ref|NP_217099.1| bifunctional (p)ppGpp synthase/hydrolase RelA [Mycobacterium tuberculosis H37Rv] MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism (Primm et al., 2000).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Primm et al., 2000: Primm TP, Andersen SJ, Mizrahi V, Avarbock D, Rubin H, Barry CE 3rd. The stringent response of Mycobacterium tuberculosis is required for long-term survival. Journal of bacteriology. 2000; 182(17); 4889-4898. [PubMed: 10940033].