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mycP1 from Mycobacterium tuberculosis H37Rv

Victor ID 172
Gene Name mycP1 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886217
NCBI Protein GI 15611019
Locus Tag Rv3883c
Protein Accession NP_218400.1
Other Database IDs UniProtKB-ID: O05461_MYCTU
UniRef100: UniRef100_A5U9L1
UniRef90: UniRef90_A5WUA4
UniRef50: UniRef50_B2HNR1
UniParc: UPI00000D4F1F
EMBL: BX842584
EMBL-CDS: CAB08091.1
RefSeq_NT: NC_000962.2
HSSP: Q45670
MEROPS: S08.131
EnsemblGenome: EBMYCG00000003705.
EnsemblGenome_TRS: EBMYCT00000003707
EnsemblGenome_PRO: EBMYCP00000003707
GenomeReviews: AL123456_GR
KEGG: mtu:Rv3883c
TubercuList: Rv3883c
HOGENOM: HBG752219
OMA: PPDETGP
ProtClustDB: CLSK792785
Taxonomy ID 83332
Gene Starting Position 4363416
Gene Ending Position 4364756
Gene Strand (Orientation) -
Protein Name MEMBRANE-ANCHORED MYCOSIN MYCP1 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-1)
DNA Sequence 
>gi|57116681:4363416-4364756 Mycobacterium tuberculosis H37Rv, complete genome
CTCATCGGCGGCTCAGCGCCCGTCTAGCCAGCGCGCCCAGGCCCAGGGCCAACGTAAGGCCGACGGCCAC
CAACGCCACAGCCGTAATCGGGCGACGATCGGGACCCGGCTCCACCACCGGGGGTGGAAGTCGTCTGACG
TTGTATGGCGCCGAAGCAGGGCCGGGCGGAATGTCCCACGTCAGCGCGGCCACCGCATCGATGACGCCGG
CGCCGACCAGGTCGTCGACCCCGCCCCCGGGGTGTCTCGCGGTGGCGGTGATCCGGTGGATGATCTGCGC
CGGCGTCAGGTCGGGGAACCGCTGCCGAAGCAGGGCCGCCAGACCCGACACATATGCCGCGGCAAACGAG
GTGCCGGCGATGGGTACCGGCCCCTCCCGGCCTTGCAGCGCATTCACCGGTTCACCGGTGTCGCCGAGCG
CGACGATGTTTTCTGCGGGCGCGGCCACGTCCACCCACGGTCCGTGCATCGAGAACGAGCTGGGCATCCC
GGTCTGGCCGATACCGCCGACGCTTAACACCAGCGGTGCGTACCACGCCGGGGTGACAACGGTCTGCACA
TTGTTCCAGCCGCGTGGGTCGCCGGGTGTGGACGGGTCCGGCGCCGGATTCTGTACGCAATCGCCACCGG
TGTTGCCGGCCGCGACCACCACCACCACGCCTTTGACGTTGACCGCATAGTCGATGGATGCACCCAGTGA
GGTTTCATCGATCGGCCTGCTCACCTTGTAGCAGGCGGCTTCACTGATGTTGATCACACCCACGCCGAGG
TTGGCGGCGTGCACCACGGCGCGGGCAAGACTGCGGATGGAACCGGCGGCCGGGGTGGCGTTGGGGTCAT
TCGGGTTGGCTTGTGAGCCGACCGGTTCGAAGGCCTCAGACGTCTGACGTAGCGAGAGCAGTCGAGCGTC
GGGCGCGACGCCGACGAACCCGTCGGTGGGCGCGGGCCGGCCCGCGATGATGGATGCTGTGAGAGTCCCA
TGGGCATCACAGTCAGACAGGCCGTTACCGGCCTGGTCGACGAAATCGCCGCCAGGTTCCGCCGGGACCC
GTGGCGAAGCGTCGACACCGGTGTCGATCACCGCCACCGTCACCCCGGCCCCGGTCGCGAACTTGTGGGC
ATCGGCCACGCCCAGATACGTGTTGCTCCACGGCGGATCGTGGAACCCGGACCCCGGCAGCGTGGTGGGC
GACGCGCACAAAACGCGCTGTTCGGTAGGCTGATCCGGGCCCGTCACGTCGGGCGGCAACGCGCCCGGAT
CGATCGGCGGTGGCGTGATGGCCGATGCGGGCGACGCGGTGAGCAACGCCAGCGCCACCGTGATCAGAAA
GATACGGTGCA
Protein Sequence 
>gi|15611019|ref|NP_218400.1| membrane-anchored mycosin [Mycobacterium tuberculosis H37Rv] MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mycP1 mutant is attenuated in chronic infection of mice (Ohol et al., 2010).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Ohol et al., 2010: Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell host & microbe. 2010; 7(3); 210-220. [PubMed: 20227664].