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Rv3870

Victor ID 165
Gene Name Rv3870
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886204
NCBI Protein GI 15611006
Locus Tag Rv3870
Protein Accession NP_218387.1
Other Database IDs UniProtKB-ID: ECC1A_MYCTU
UniRef100: UniRef100_O69735
UniRef90: UniRef90_O69735
UniRef50: UniRef50_O69735
UniParc: UPI00000D5FEB
EMBL: BX842584
EMBL: AE000516
EMBL-CDS: CAA17962.1
EMBL-CDS: AAK48351.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
TCDB: 9.A.25.1.1
EnsemblGenome: EBMYCG00000001071
EnsemblGenome_TRS: EBMYCT00000001071
EnsemblGenome_PRO: EBMYCP00000001071
EnsemblGenome: EBMYCG00000071330
EnsemblGenome_TRS: EBMYCT00000071335
EnsemblGenome_PRO: EBMYCP00000069394
GenomeReviews: AE00051
Taxonomy ID 83332
Gene Starting Position 4346480
Gene Ending Position 4348723
Gene Strand (Orientation) +
Protein Name POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN
DNA Sequence 
>gi|57116681:4346480-4348723 Mycobacterium tuberculosis H37Rv, complete genome
GATGACGACCAAGAAGTTCACTCCCACCATTACCCGTGGCCCCCGGTTGACCCCGGGCGAGATCAGCCTC
ACGCCGCCCGATGACCTGGGCATCGACATCCCACCGTCGGGCGTCCAAAAGATCCTTCCCTACGTGATGG
GTGGCGCCATGCTCGGCATGATCGCCATCATGGTGGCCGGCGGCACCAGGCAGCTGTCGCCGTACATGTT
GATGATGCCGCTGATGATGATCGTGATGATGGTCGGCGGTCTGGCCGGTAGCACCGGTGGTGGCGGCAAG
AAGGTGCCCGAAATCAACGCCGACCGCAAGGAGTACCTGCGGTATTTGGCAGGACTACGCACCCGAGTGA
CGTCCTCGGCCACCTCTCAGGTGGCGTTCTTCTCCTACCACGCACCGCATCCCGAGGATCTGTTGTCGAT
CGTCGGCACCCAACGGCAGTGGTCCCGGCCGGCCAACGCCGACTTCTATGCGGCCACCCGAATCGGTATC
GGTGACCAGCCGGCGGTGGATCGATTATTGAAGCCGGCCGTCGGCGGGGAGTTGGCCGCCGCCAGCGCAG
CACCTCAGCCGTTCCTGGAGCCGGTCAGTCATATGTGGGTGGTCAAGTTTCTACGAACCCATGGATTGAT
CCATGACTGCCCGAAACTGCTGCAACTCCGTACCTTTCCGACTATCGCGATCGGCGGGGACTTGGCGGGG
GCAGCCGGCCTGATGACGGCGATGATCTGTCACCTAGCCGTGTTCCACCCACCGGACCTGCTGCAGATCC
GGGTGCTCACCGAGGAACCCGACGACCCCGACTGGTCCTGGCTCAAATGGCTTCCGCACGTACAGCACCA
GACCGAAACCGATGCGGCCGGGTCCACCCGGCTGATCTTCACGCGCCAGGAAGGTCTGTCGGACCTGGCC
GCGCGCGGGCCACACGCACCCGATTCGCTTCCCGGCGGCCCCTACGTAGTCGTCGTCGACCTGACCGGCG
GCAAGGCTGGATTCCCGCCCGACGGTAGGGCCGGTGTCACGGTGATCACGTTGGGCAACCATCGCGGCTC
GGCCTACCGCATCAGGGTGCACGAGGATGGGACGGCTGATGACCGGCTCCCTAACCAATCGTTTCGCCAG
GTGACATCGGTCACCGATCGGATGTCGCCGCAGCAAGCCAGCCGTATCGCGCGAAAGTTGGCCGGATGGT
CCATCACGGGCACCATCCTCGACAAGACGTCGCGGGTCCAGAAGAAGGTGGCCACCGACTGGCACCAGCT
GGTCGGTGCGCAAAGTGTCGAGGAGATAACACCTTCCCGCTGGAGGATGTACACCGACACCGACCGTGAC
CGGCTAAAGATCCCGTTTGGTCATGAACTAAAGACCGGCAACGTCATGTACCTGGACATCAAAGAGGGCG
CGGAATTCGGCGCCGGACCGCACGGCATGCTCATCGGGACCACGGGGTCTGGGAAGTCCGAATTCCTGCG
CACCCTGATCCTGTCGCTGGTGGCAATGACTCATCCAGATCAGGTGAATCTCCTGCTCACCGACTTCAAA
GGTGGTTCAACCTTCCTGGGAATGGAAAAGCTTCCGCACACTGCCGCTGTCGTCACCAACATGGCCGAGG
AAGCCGAGCTCGTCAGCCGGATGGGCGAGGTGTTGACCGGAGAACTCGATCGGCGCCAGTCGATCCTCCG
ACAGGCCGGGATGAAAGTCGGCGCGGCCGGAGCCCTGTCCGGCGTGGCCGAATACGAGAAGTACCGCGAA
CGCGGTGCCGACCTACCCCCGCTGCCAACGCTTTTCGTCGTCGTCGACGAGTTCGCCGAGCTGTTGCAGA
GTCACCCGGACTTCATCGGGCTGTTCGACCGGATCTGCCGCGTCGGGCGGTCGCTGAGGGTCCATCTGCT
GCTGGCTACCCAGTCGCTGCAGACCGGCGGTGTTCGCATCGACAAACTGGAGCCAAACCTGACATATCGA
ATCGCATTGCGCACCACCAGCTCTCATGAATCCAAGGCGGTAATCGGCACACCGGAGGCGCAGTACATCA
CCAACAAGGAGAGCGGTGTCGGGTTTCTCCGGGTCGGCATGGAAGACCCGGTCAAGTTCAGCACCTTCTA
CATCAGTGGGCCATACATGCCGCCGGCGGCAGGCGTCGAAACCAATGGTGAAGCCGGAGGGCCCGGTCAA
CAGACCACTAGACAAGCCGCGCGCATTCACAGGTTCACCGCGGCACCGGTTCTCGAGGAGGCGCCGACAC
CGTG
Protein Sequence 
>gi|15611006|ref|NP_218387.1| ESX-1 secretion system protein EccCa [Mycobacterium tuberculosis H37Rv] MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTAMICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGTTGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGGPGQQTTRQAARIHRFTAAPVLEEAPTP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Rv3870 mutant is attenuated in mice (Stanley et al., 2003).
COG COG1674D, under D: Cell cycle control, cell division, chromosome partitioning
References
Stanley et al., 2003: Stanley SA, Raghavan S, Hwang WW, Cox JS. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 13001-13006. [PubMed: 14557536].