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mmpL8 from Mycobacterium tuberculosis H37Rv

Victor ID 153
Gene Name mmpL8 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886145
NCBI Protein GI 15610959
Locus Tag Rv3823c
Protein Accession NP_218340.1
Other Database IDs UniProtKB-ID: MMPL8_MYCTU
UniRef100: UniRef100_A5U9F2
UniRef90: UniRef90_A1KQF8
UniRef50: UniRef50_A5U9F2
UniParc: UPI000012F274
EMBL: BX842584
EMBL: AE000516
EMBL-CDS: CAB10022.1
EMBL-CDS: AAK48298.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
TCDB: 2.A.6.5.4
EnsemblGenome: EBMYCG00000001483
EnsemblGenome_TRS: EBMYCT00000001483
EnsemblGenome_PRO: EBMYCP00000001483
EnsemblGenome: EBMYCG00000070486
EnsemblGenome_TRS: EBMYCT00000070491
EnsemblGenome_PRO: EBMYCP00000068550
GenomeReviews: AE000516
Taxonomy ID 83332
Gene Starting Position 4288259
Gene Ending Position 4291528
Gene Strand (Orientation) -
Protein Name PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8
DNA Sequence 
>gi|57116681:4288259-4291528 Mycobacterium tuberculosis H37Rv, complete genome
CCTAAAGCCTGAGCCCGTCGTGTAACCAAAGACCGATCAGATCGTCGTCGTCGGGCGGTGATTGCTCTTC
TTCTTCCTTGGGCAACAACGGCTTACGTTTGGTTCGTTGGGCACGGCCACGGCGTCGGCCAAGGGGCCAC
CAGGTTGCCGGCCGCCAGCTTGACGGCAACCACCAGTTCGCCTGCCCAACCAACACGGCAATGGCGGGCA
CGGTAACGGTACGCACCAAGAAGGTATCCAGCAAAAGCCCGGTCCCTAGGACGAACGCACCTTGAACCAC
GCTACCCAAGCTGGCGAATACCAGACCGTACATCGAGGCAGCCATGATCAAACCCGCCGCAGTGATCACA
CCACCTGTTGAGGCCACGGTCCGGATGACACCGGAACGCACCCCCAAGACGGCCTCTTCACGCAGCCTAG
AAATAAGCAGCATATTGTAATCTGCGCCCACCGCGACCAATATAACGAAGGTCAATCCCGGAATGCTCCA
ATGCATTTCCTGACCGAGTAAAAATTGGAACACGATAACGCCAATACCGAGCGCCGCCAGGTACGATACG
ATAACCGAGCCGATCAGATACAGCGGTGCCACAATCGCACGCAGCAAAACGATCAATATGAGCAGAACGA
TGCAGACGGTCATGGCGATGATCAATCGGAGGTCGTGATCGGAGTAGTCGCGCGTGTCCTTGAGAACGAC
GGGCAATCCGACGACAGACACCTTGGCATCGGCCAGTGCGGTATTTGGTTGCGCCCCTCGAGCGGCCGCC
GTGATCGCGTCAATTTGGTCCATGGCAGCAGTGCTGAATGGATTCAGGTCGGTTTGTATCAAATACCGTA
TTGAGTGGCCGTCGGGTGAAATGAAGGCCGCCGCGACTTTTTTGAGTTGGTCTACATTCAGCCCGCCTAG
CAGATCCCGATACTCTGACGGCATCGTCTCGGCTTTGACGCTCTCACCGGTGGCATACGACAACAACTCC
GGGGGAATATAGAACCCCGCCATCGCCGGCGTGGTCGCGGTGTCCTTCATTGCCAATAGGAACGCCGAGG
CCTCGCCCAACCCGAAACCCATCTTCTTCACCTGGTCGACCAACAACTGCACGCCCTCAGCCAGTTGCCG
GCTCCCGTCGGCGAGATCATTGACCCCCTTGTTCACCAGGTTGATCTTGGATCGCACACCACCAGGACTG
CTCATCCCCAGTGAACCCATCGCCCTGATGACGGTGGCCAGCGCCCCGCGTAATCCGGACACGGTGGCTG
CCAGGGTCTGCACTGCGCGCGTGGCCTGCAGCTGTCGAGCCAACTCAGATATCTTTGCCAGCGTTCCGTC
GTCGCGCGCTGTGACCAAACGCTGCAGTTCGGTGCGCGCACTGGCACAAGCCGGATCGGCAGTGCACATC
GGGCTGCTATCCAGCGCCCCCAGCACCGGGCTTGCCCACTCGGTGTTGTTCGCTACAAAGCTCGCATCCG
CGTCAATGGTGTCACCGAGTGCCCGCATGCTGCCGATCAGCTTCTCCGCGCCTTCCAGTTCGCCGAGAAC
CCTGTTGCCCCCGAGCAGGTCCTGAAGGTACGCCAGCGCGTCGATGAGGCCGCCGACCGTGGATATGGCC
CGGTTAACTTGGGCCCGTACGTCGCCGAGTTTGCTCGCCATCAGGTTGGCTCCACCGGCCAGTTTGTCGA
TGTCGCCGGTGTGCACAGCGATCTGCTTGGAACCCTCATCCAGCTTGCTGCCGACTTCGCCAGCCTGCCA
GGACGTCCGGGCCTGCTCCAGCGACCGTCCAGCGGGTCGGGTAATGCCCCTGACCATCGCGACACCCGGC
ACTTGGCTCACCCGCTGCACCATCTGCTCTAGGTCGGCGAGAGCCTTCGGCGTGCGCAGATCCGTCGAGG
ATTGGATGAACAGGTACTCGGGAATGATCAGGTTAGACGGGAAATGCTTGTCCAACGCGGCATACCCGAT
CGAACTCTCGACGGAAGCCGGAAGCGTCTTGCGATCGTCGTAGTTGTACCGGGCCAGTCCTGCGCAGCCG
GCCAGAATAACCAGCACCAGCGCGCTGGCGAGCAGATGAGTCTTGGGCCGACGCACGATGTGCACCCCCG
AACTCCGCCAAAAGCGCCGGGTGAGGTCACGGCGCGGCGCGATCCAACCGCGACGCCCGGTCAGCACCAT
CAGGGCGGGTAGCAGTGTGACAGCTGCGAAGAAGACCACGGCTACCGAGATTCCCAACATCGGACCAACC
GTTTTGAGAATTCCCAGTTGGGTAAACACCATCCCGAGAAAGGTGATTGCTACGGTAGCCGCGGAGGCGG
CGATCACCTTACCGATGGATGTCAATGCCTTCTTGACGGCTTGATCCGAATCCGCGCCCTGCCGTAAATA
GTCGTGATATCGACTAATCAGAAATACCGCGTAATCCGTTCCCGCACCGACCATCATCCCGCTCATAAAA
ATAATGCTCTGGTTAGCAATACCGAGGCCCGCCAAGCCGGCTATTGCAACGAGGCGCTGTGCAACCACCA
CGGACATGCCAATTGTTATCAATGGCAACACCATGGTGATCGGATTCCCGTAGATGATCAGCAAAATGAC
CAACAACAGGATCGTGATCGCAAACTCGATGCGACTGCGGTCCCGTTGCCCGGTGAGGTTCAGATCGGCG
ACGGTGGCCGCGGGCCCGGTCAGGTTAGCCGTCAGTGTCGAGCCTGCGACCTGGTGTTCGACGATGTCAG
CGACGCGGGCGTACGCCTGCTTGGACTGGGTCGAACCCAGGTCGCCGGGAAGGCCGACCGGCAGGATCCA
GGCCTGATTGTCTTTGCTGGTCATGAGCTCCCGCAGGGGCGGTGTGGTGACGAAGTCCTGGAGCATCACG
ACGTCTCGAGTATCGCGTCGCAGGGCGTCAACCAGCTCTTTGTAGCTGCGTTCATCGGCCGCGCCGAGCC
CTTTGGCATCGCTGAGCACCACCACCGCAACGCTCTGCAACCCGGCTTCACGAAATGCCGCGGTCATCTG
CCGGGTCGAGACCAACACCGGGGCGTCCGATGGCAGAATCGCCACTGGATGCCGCTGGGAGATCGCGTCC
AGGGACGGCACCGTCGGCGCAAGCAGACCCGCAAGCGCGACCCAGAAGGCGATCACCACCCACGGCCTTC
GGACGATAAGGCGCCCTAGCCGCGGAAAGACACCCCCGTCACCGGTTGGCCTAAGCGGTTTCGATCGTAA
GTTCGTCGAGGGTCTCGGTGTTCTGACAGGCTGCATCAAGACGTCGCACA
Protein Sequence 
>gi|15610959|ref|NP_218340.1| integral membrane transport protein MmpL8 [Mycobacterium tuberculosis H37Rv] MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLRL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mmpL8 mutant is attenuated in mice (Converse et al., 2003).
COG COG2409R, under R: General function prediction only
References
Converse et al., 2003: Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, Cox JS. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(10); 6121-6126. [PubMed: 12724526].