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mbtB from Mycobacterium tuberculosis H37Ra

Victor ID 1881
Gene Name mbtB from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214000
NCBI Protein GI 148662215
Locus Tag MRA_2406
Protein Accession YP_001283738.1
Other Database IDs UniProtKB-ID: A5U576_MYCTA
UniRef100: UniRef100_P71717
UniRef90: UniRef90_Q7TYQ4
UniRef50: UniRef50_Q1B6A7
UniParc: UPI00000D5001
EMBL: CP000611
EMBL-CDS: ABQ74176.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065882.
EnsemblGenome_TRS: EBMYCT00000065887
EnsemblGenome_PRO: EBMYCP00000063997
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2406
eggNOG: COG1020
HOGENOM: HBG676528
OMA: PARSEDI
ProtClustDB: CLSK791816
BioCyc: MTUB419947:MRA_2406-MONOMER
Taxonomy ID 419947
Gene Starting Position 2683560
Gene Ending Position 2687804
Gene Strand (Orientation) -
Protein Name dihydroaeruginoic acid synthetase
DNA Sequence 
>gi|148659757:2683560-2687804 Mycobacterium tuberculosis H37Ra, complete genome
GTTATCGGACATCGGCACTCACCATCCGGGCCACGGCGTCGAGGTGATCGTTGAGATAGAAGTGACCACC
ATCAAAGTGCGACAGCGTGAAGCGACCGGAGGTGTGAGTCTCCCAACTGGTCAACATCTCCCGGCTGATG
CGGTGGTCGCGGTTGCCGCCGACCGCGTGGATGTTGGCGCGGATGCGCACGTCGGGTGGACATGAATAGC
CGCTGAGGGCCCGATAGTCGGCCTTGACCGCCGGCACCAGCAGTTCAACGAATTCCTCGTCCTCGAGCAG
CACGGGATCGGTGCCGCCAAGATCCACCATGTCGGCCAGGACGTCACGGTCGGCGGTCGGCAACGGTCCG
GACGCGGCCACCGTCGACGGAGCCTGACCGGAGGAAGCCCACAGTGCACGTACCGGCACGCCATTGCGCT
CGGCGAGGCGAGCGAACTCGAAGGCCACTATCGCACCCATGCAATGGCCGAACAGCGTCAGCGGAGCCGT
CAGGTGCCAGTCGCCCGCCTCGAACAGCTCGAGCGCCAGCGCCTCGATGCTGTCTGCCGCCGGGTGGCTG
CGCCGGTCAGCCCGCTGCGGGTACTGCACCACGAACGTGTCAACGTCGTTGGCCACTAACGATTTTGCCA
ACCACCGGTAAGCCGCGGCAGCGCCGCCGGCGTGTGGAAACACCAGCACCGCGCCGGGCTTGTCAGTACC
GGTGAACCGCTTCACCCACGGTTTGAAGGCTGGCTGTGCGGGCTGCTCGATCGGATCGAGCGCCGCCATC
ACGTCGGCACTTGTCATATTCGCGATTTCTAAGTACACCTCGGCGACCAGTTCGAGTCGGTCGGCGTTGG
CTTCCCGACCGGTGAGCAACTGGGCCAACGCGGCAATGGTCCTGGCGGCAAACATGTCGGCGACCATCAG
GCTCGGCGAATCCAGCCACCGCCGGATACCGGCGACGACCTGGGTCGCAAGCACGGAATCGCCGCCCAGG
GCAAAGAAGTCGTCGTGCACGCCCACGGCATCGTTGGCACGGCCCAGGATGTCCGCGACGATGCGGCGCA
GTGCCCGCTGAAGCACCGTTCGCGGCGCCGCATAGGGTGCCGATCTGTCGCCAGACCGCTCGACCTCGGC
GGCAAGCAGGGCGCCAACCTCCGCGCGGTCGATCTTGCCGCTGTCGGTAAAGGGGATGCGGTCTAGCAGC
GTGACGTGGCGCGGAATCATGTGCGCGGGCACCAGATCGGCGAGCTGCTGTCGAATCGACTCCGCGGTCA
CGCCGGCATCGTCGACGCAGACCGCCGCGGCCAGCACATCGGACCCGCCAGGAAGCACGGTGGCCGCCGC
CGCGTGCACACCGGGCAAGCGCTGCAGCGCGGCTTCGATCTCGCCGAGTTCGACGCGGTACCCGCTGATC
TTGACGCGGTGATCGGCACGGCCGACGAACTCCAGGGTGCCGTCGTGCCAGTAGCGGGCCAGATCACCGG
TGCGATACCAGGTGCGGCCGTCATGCTCGACGAAGCGCTCCGCGGTCAGCTCGGGACGGCCACGGTAACC
CCGGGCGATTCCGCGACCGGACACCCACAACTCACCGGCCACCCAATCGGGGCAGTCGTCGCCGCTGTCG
GCCACTACCCGGCAGGCGTTGTTGGGAAACGGGACGCCGTATGGCACCGAGGCCCAGTCCGGTGGCAGAT
TGGCCGCGTCCTGGACCTCGAAAATGGTTGCGTGGACCGCGGTTTCGGTGGCTCCACCCAACCCCGCGAA
CCGTGCGCTCGGCGCTTGCACCTGCAGGCGGCGGGCCAGGTCGGGACGCACCCAGTCGCCGCCGACGGCC
ACCGCTCGCAGCGACGACAGCCGGCCCCCGCCGACTTCGAGCAGCATGTCCAACCAGCCCGGCATGAAAT
TCAACGCCGTGACCTCGTAAGTGTCGATAAGCCGGGCCCAGGCGTCGGGATCGCGGCGCTGCGCTTCGTC
GACCACCACGATCGCTCCGCCGGAGCGCAGGGCGGCGAAGATGTCCAGCACCGACATGTCGCACTCCAGC
GTCGCCAGGGCAAGCCAGCGATCTGCGGCGCCTAGCTCGAAGTGCCGGATGAAGGTCTCCACGGTGTTCA
TCGCGGCGTCGTGCGCCACCTCGACACCCTTGGGTTCCCCGGTTGAGCCCGAGGTGAACAACACATAGGC
GAGCGCGGTGGGATCGCTAGGCCCGGGCACGAATTCTGCCGGCGCGGCGGCAAGCACGTCAGCCAGCAAC
AGCGTCGGGACCGGCACCCGCACTTGGCATGGCGGGCCGCAAACGAGCGCTAAGTTGACCGAACCGGTCG
CCAGGATGCGCTCCGCGCGGTCGCGGGGCTGGTCGACGCCGATCGGCAGATAGACCCCGCCGGCGGCCAA
AATCCCCAGCACAGCCGCCACTTGTTCGCCCGTTTTCGGACCCAGCACCGCGACGGTGTCGCCGACTCGT
AGGCCCGCAGCACGCAGCGCCGCGGCCACCGCCGATGCCTGGTCGCGCAGTTGGGCGTAGCTCAAGTCGC
CGGAACTGGCGAACACCGCCGGCGCGTCGGGCTGCTGTTGGGCCTGGCGGAAAAACCCGTCGTGCAGCGC
CTCGGTGCTGGGGGCGGCGGTGCGACCGTTCAGCGCCGCGCGCACCGCGCGTTGCGCGGCGGGTAGCGCG
GACGGGCTCGGCGCATCCCAGGCGTCGTCCCCGGCGGCCAACCGGAGCAATTCGTCGACCTGGTGGGTGA
ACATGGCGTCGATGACGCCGGGTGCAAAGACCCCCTCGCGGACATCCCAGTTCACCAGCACACCGCCGTC
GAACTCGGTGACCTGGGCGTCGAGCAGCACCTGGGGCCCCTGCGAAATGATCCATCCGGGTGTGCCGAAT
TGCTCGGTGACGTCCGGGCAGAAAAGGTCGCCGAGCCCCAGCGCGCTGGTGAATACCACCGGTGCCAGCA
CCTGGGTGCCACGGTGGCGGCTGAGGTCACGCAGCACAGACAGCCCGGGGTATGCACTGTGGCCTGCGGC
GCTGCGCAGGGCTTCCTGCACCGCCTGCGCCCGCGCCGCCGCCGTGCGCGCACCGGTCAGATCGACGTCG
AGCAACAGCGAGGAGGTGAAGTCACCGACCAGCAGGTCGACGTCTGGATGCAGGGCCTGGCGACTGAACA
ACGGCAGGTTCAGCAGGAACCGCGACGACGCTGACCAACGCGCCAGCACGTTGGCAAAGGCCGCGGCCAG
CGTCATCGCCGGGGTGATGCCGCGGGCCCGGGCTCGGGCGAACAACGCGTCGCGGGTCTGCGGGTCTAGC
CAGTGCCAGCGCCGGGTGCTGCGGCGCCGGTCGCGTTCGCCGCCGGCCCGGGTAGGCAGCGCGGGCGGAT
CCGGCAGCTGCGGGATGCGCTGCGCCCACCAGTCCCGGTCGGCGTCGCGAACCGGTTGGGGCAGCGTCTC
CTCCGCCTCGATAGCCTGCCGGTATTCCCGGTAGGTGTAGCCCAGTGCCGGCGGTTCACGGCCGTCATAG
AGGGCCGCCAGGTCGGCCAGCAAGATGCGGTAGCTCATCGCGTCAGCGGCCTGCATGTCCAGGTCGACAT
GTAGGCGGGTGCGCTCCCCCGGTAATAACGTCAACGCAAGTTCGAATACCGCACCGTCGAGCTGCTGGTG
CGATTTGGCGTCGCGGATCCCCGCCAACCGCTGATCGACGACATCCGGGGCCACGTGACGCAGGTCGGCA
ACACTGATGGGAAAGTCGCGAGATCCCGCCGCCGGCGGGATGCGCTGGGTGCCGTCGGGCAAGAACTGCA
CCCGCAGCATCGGGTGCCGCAGCGCCAACCGGGTGGCCGCCGCGCGGAGCCTGTCCGGATCGACCCGGGC
ACCATCGAACTCGACGTAGAGGTGCCCAGCTACCCCGCCGAGCTGTTGGTGGTCGTGGCGGCCGACCCAC
ATCGCGTGCTGCATCGGCGCCAGCGGGAAAGGCTCGCCTTCCTGGGATAACCCGGCATCCCCTGGTGCGG
CAACTGCCGTGGGCGCGACGCCGGTGCCGGCGGACACCAGTTGGGACCAGGCCTCGATTGTGGGTGTGGC
GGCCAGTGTGGCGAAGTCGACGGCGATGCCCTTCCGGCGCCAGCGCCCCACCAGCGACATCATCCGGATC
GAGTCCAGGCCCTGACCAACGAGGTTGGCGCCGGGGTGCAGAGCATCGGCGCGGACACCGAGCAACTCTG
CGACCTCGGCGCGAATGATCTCCGAGCACGCCGTAGCATGCACCA
Protein Sequence 
>gi|148662215|ref|YP_001283738.1| dihydroaeruginoic acid synthetase [Mycobacterium tuberculosis H37Ra] MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells (De et al., 2000).
COG COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
De et al., 2000: De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu Y, Barry CE 3rd. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(3); 1252-1257. [PubMed: 10655517].