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ddl

Victor ID 312
Gene Name ddl
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888415
NCBI Protein GI 15610118
Locus Tag Rv2981c
Protein Accession NP_217497.1
Other Database IDs UniProtKB-ID: DDL_MYCTU
UniRef100: UniRef100_A5U6Z2
UniRef90: UniRef90_A1KMX5
UniRef50: UniRef50_A0PQ03
UniParc: UPI00001290B8
EMBL: BX842581
EMBL: AE000516
EMBL-CDS: CAB05431.1
EMBL-CDS: AAK47388.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 3LWB
EnsemblGenome: EBMYCG00000001895
EnsemblGenome_TRS: EBMYCT00000001897
EnsemblGenome_PRO: EBMYCP00000001897
EnsemblGenome: EBMYCG00000070331
EnsemblGenome_TRS: EBMYCT00000070336
EnsemblGenome_PRO: EBMYCP00000068395
GenomeReviews: AE000516_GR
Geno
Taxonomy ID 83332
Gene Starting Position 3336795
Gene Ending Position 3337916
Gene Strand (Orientation) -
Protein Name D-alanyl-alanine synthetase A
DNA Sequence 
>gi|57116681:3336795-3337916 Mycobacterium tuberculosis H37Rv, complete genome
GCTAGTGCAGGCCCACGCCGCGGGCCAATGTCGTCTCGATCATCGTCGCCAGCAGGGTCGGATAGTCGAC
ACCGCTGGCCGCCCACATCCGCGGGTACATCGAGATCGTGGTGAATCCCGGCATCGTGTTGATCTCGTTG
ATCACCGGACCGTCGTCGGTGAGGAAGAAGTCCACCCTGGCCAGACCCCGGCAGTCGATAGCCGCGAACG
CCCGGATCGCCAGCTGACGAATCGCCTCTGCGACCTGGTCATCGACCTTGGCGGGCACGTCCAATTCGGC
TGCGTCGTCGAGATACTTGGTTGCGAAGTCGTAGAAAGAGTCCTCGCGTCCCCGCACCCCGGCCACCCGG
ATCTCCCCCAGCGTGCTGGCTTCCAGTGTGCCGTCCGGCATTTCGAGCACACCGCATTCCAGCTCGCGGC
CGCTGATCGCGGCCTCGACGATGACCTTAGGGTCATGCCGGCGGGCCCGCGCGACCGCGGCGGGCAGTTG
ATCCCAACTCGACACCCGGCTAACACCGATCGACGAGCCGCCTCGGGCGGGTTTGACGAACACCGGTAAG
CCCAGCCGTTCGCACTCCTGGCGGTGCAGTGTCGACCGCGGCGGACGCAGCACCGCGTACGCACCCACCG
GAAGTCCATCGGCGGCGAGCAGCTTCTTGGTGAACTCCTTGTCCATGCCGACGGCACTGGCCAGCACACC
GGCGCCCACGTAGGGCACCCCGGCGAGTTCGAGCAGTCCCTGGATCGTGCCGTCCTCGCCGTACGGGCCG
TGCAGTACCGGGAACACCACGTCGACCGACTCCAGAACCTCGCCGGCCCCGGGCGGCAGCGACACCAACT
GGCCACCACGCCGCGGATCGGCCGGCAGCGCCAGCTCGGTGCCCGATCCTGATTTGACCTGAGGAAGCTC
CCGGTTGGTGATCGTCAGGGCGTCGGGGTTGGCGTCGGTGAGCACCCACGAACCTGCCGGGGTGATACCC
ACCGCGATCACGTCGAACCGCCGCGAGTCCAGGTTGCGCAGGATGCTGCCGGCGGACACACACGAGATGG
CGTGCTCGTTGCTGCGCCCGCCGAACACGACGGCAACGCGGACACGCCGATCACGCCGGTCGTTAGCACT
CA
Protein Sequence 
>gi|15610118|ref|NP_217497.1| D-alanine--D-alanine ligase [Mycobacterium tuberculosis H37Rv] MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLHRQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELECGVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLATMIETTLARGVGLH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG1181M, under M: Cell wall/membrane/envelope biogenesis
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].