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mycP1 from Mycobacterium tuberculosis H37Ra

Victor ID 1890
Gene Name mycP1 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214557
NCBI Protein GI 148663750
Locus Tag MRA_3922
Protein Accession YP_001285273.1
Other Database IDs UniProtKB-ID: A5U9L1_MYCTA
UniRef100: UniRef100_A5U9L1
UniRef90: UniRef90_A5WUA4
UniRef50: UniRef50_B2HNR1
UniParc: UPI00000D4F1F
EMBL: CP000611
EMBL-CDS: ABQ75711.1
RefSeq_NT: NC_009525.1
MEROPS: S08.131
EnsemblGenome: EBMYCG00000065881.
EnsemblGenome_TRS: EBMYCT00000065886
EnsemblGenome_PRO: EBMYCP00000063996
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3922
eggNOG: COG1404
HOGENOM: HBG752219
OMA: PPDETGP
ProtClustDB: CLSK792785
BioCyc: MTUB419947:MRA_3922-MONOMER
Taxonomy ID 419947
Gene Starting Position 4371862
Gene Ending Position 4373202
Gene Strand (Orientation) -
Protein Name membrane-anchored mycosin Mycp1
DNA Sequence 
>gi|148659757:4371862-4373202 Mycobacterium tuberculosis H37Ra, complete genome
CTCATCGGCGGCTCAGCGCCCGTCTAGCCAGCGCGCCCAGGCCCAGGGCCAACGTAAGGCCGACGGCCAC
CAACGCCACAGCCGTAATCGGGCGACGATCGGGACCCGGCTCCACCACCGGGGGTGGAAGTCGTCTGACG
TTGTATGGCGCCGAAGCAGGGCCGGGCGGAATGTCCCACGTCAGCGCGGCCACCGCATCGATGACGCCGG
CGCCGACCAGGTCGTCGACCCCGCCCCCGGGGTGTCTCGCGGTGGCGGTGATCCGGTGGATGATCTGCGC
CGGCGTCAGGTCGGGGAACCGCTGCCGAAGCAGGGCCGCCAGACCCGACACATATGCCGCGGCAAACGAG
GTGCCGGCGATGGGTACCGGCCCCTCCCGGCCTTGCAGCGCATTCACCGGTTCACCGGTGTCGCCGAGCG
CGACGATGTTTTCTGCGGGCGCGGCCACGTCCACCCACGGTCCGTGCATCGAGAACGAGCTGGGCATCCC
GGTCTGGCCGATACCGCCGACGCTTAACACCAGCGGTGCGTACCACGCCGGGGTGACAACGGTCTGCACA
TTGTTCCAGCCGCGTGGGTCGCCGGGTGTGGACGGGTCCGGCGCCGGATTCTGTACGCAATCGCCACCGG
TGTTGCCGGCCGCGACCACCACCACCACGCCTTTGACGTTGACCGCATAGTCGATGGATGCACCCAGTGA
GGTTTCATCGATCGGCCTGCTCACCTTGTAGCAGGCGGCTTCACTGATGTTGATCACACCCACGCCGAGG
TTGGCGGCGTGCACCACGGCGCGGGCAAGACTGCGGATGGAACCGGCGGCCGGGGTGGCGTTGGGGTCAT
TCGGGTTGGCTTGTGAGCCGACCGGTTCGAAGGCCTCAGACGTCTGACGTAGCGAGAGCAGTCGAGCGTC
GGGCGCGACGCCGACGAACCCGTCGGTGGGCGCGGGCCGGCCCGCGATGATGGATGCTGTGAGAGTCCCA
TGGGCATCACAGTCAGACAGGCCGTTACCGGCCTGGTCGACGAAATCGCCGCCAGGTTCCGCCGGGACCC
GTGGCGAAGCGTCGACACCGGTGTCGATCACCGCCACCGTCACCCCGGCCCCGGTCGCGAACTTGTGGGC
ATCGGCCACGCCCAGATACGTGTTGCTCCACGGCGGATCGTGGAACCCGGACCCCGGCAGCGTGGTGGGC
GACGCGCACAAAACGCGCTGTTCGGTAGGCTGATCCGGGCCCGTCACGTCGGGCGGCAACGCGCCCGGAT
CGATCGGCGGTGGCGTGATGGCCGATGCGGGCGACGCGGTGAGCAACGCCAGCGCCACCGTGATCAGAAA
GATACGGTGCA
Protein Sequence 
>gi|148663750|ref|YP_001285273.1| membrane-anchored mycosin Mycp1 [Mycobacterium tuberculosis H37Ra] MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mycP1 is attenuated in chronic infection of mice (Ohol et al., 2010).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Ohol et al., 2010: Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell host & microbe. 2010; 7(3); 210-220. [PubMed: 20227664].