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sigH from Mycobacterium tuberculosis CDC1551

Victor ID 60
Gene Name sigH from Mycobacterium tuberculosis CDC1551
Sequence Strain (Species/Organism) Mycobacterium tuberculosis CDC1551
NCBI Gene ID 922907
NCBI Protein GI 15842811
Locus Tag MT3320
Protein Accession NP_337848.1
Other Database IDs UniProtKB-ID: RPOE_MYCTU
UniRef100: UniRef100_P66808
UniRef90: UniRef90_P66808
UniRef50: UniRef50_P66808
UniParc: UPI0000033263
EMBL: BX842582
EMBL: AE000516
EMBL-CDS: CAB08314.1
EMBL-CDS: AAK47662.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
DIP: DIP-13485N
EnsemblGenome: EBMYCG00000000644
EnsemblGenome_TRS: EBMYCT00000000644
EnsemblGenome_PRO: EBMYCP00000000644
EnsemblGenome: EBMYCG00000068955
EnsemblGenome_TRS: EBMYCT00000068960
EnsemblGenome_PRO: EBMYCP00000067019
GenomeReviews: AE000516_
Taxonomy ID 83331
Gene Starting Position 3593801
Gene Ending Position 3594655
Gene Strand (Orientation) -
Protein Name RNA polymerase sigma factor RpoE
DNA Sequence 
>gi|50953765:3593801-3594655 Mycobacterium tuberculosis CDC1551, complete genome
CTCATGACGACACCCCCTCGTGCGCCTGCTCGCCCCTGGCAAACCCCCGATCCCTGGCCACATCGGCTAA
AAGACCGCGCAACTGACGTCGGCCGCGATGAAGCCTCGACATCACGGTGCCGATCGGAGTATCCATGATC
TCGGCGATCTCCTTGTAGGGGAAACCTTCGACATCGGCGTAGTAGACCGCCATCCGGAACTCTTCCGGCA
ATGCCTGCAGCGCCTCTTTGATCTCGGTGTCCGGCAACGCTTCTAACGCTTCGACTTCAGCCGAGCGCAG
CCCGGTCGAGGAATGCTCGGCGTTGGACGCCAGTTGCCAATCGGTGATCTGCTCGGTCGGATACTCCGCC
GGTTGCCGCTGTTTCTTGCGATAGCTGTTGATGTAGGTGTTGGTCAGTATCCGGTAGAGCCAGGCCTTGA
GATTGGTACCGTGCCGGAACGAACGAAATCCCGCATAGGCCTTCACCATCGTCTCCTGGAGCAAGTCCTC
GGCGTCGGCCGGATTGCGCGTCATCCGCAGCGCACCGCCGTACAGCTGGTCCAACAGGGGAATCGCGTCG
CGCTCGAAACGCGCGGTCAACTCCTCGTCTGTCTCCTCAGACGGCCCAGGCTGCAGACCCGCCGAACCGG
TTACACCATCGATGTCGGCCATCTTGATTAACTGGGTCCCTTCGTTTGCGGTGTCGCCGGACAGCACCGG
CGCGGACACCGGACGTGCGAGCATGCGAGCCAACCGCTTCTCACCCAACAGGCTCGTCGCCGTTGACACC
AGACTCCCCTCGTCCCAATGTAGAGGCCGCGACCGACACTGTCTGCACCGGTCTGGCCAGCCACGTGGCT
GCAGGAACCGAACCA
Protein Sequence 
>gi|15842811|ref|NP_337848.1| RNA polymerase sigma factor RpoE [Mycobacterium tuberculosis CDC1551] MVRFLQPRGWPDRCRQCRSRPLHWDEGSLVSTATSLLGEKRLARMLARPVSAPVLSGDTANEGTQLIKMADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002).
COG COG1595K, under K: Transcription
References
Kaushal et al., 2002: Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC, Fleischmann RD, Bishai WR. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(12); 8330-8335. [PubMed: 12060776].