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Rv3534c

Victor ID 310
Gene Name Rv3534c
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888387
NCBI Protein GI 15610670
Locus Tag Rv3534c
Protein Accession NP_218051.1
Other Database IDs UniProtKB-ID: HOA_MYCTU
UniRef100: UniRef100_A1KPL9
UniRef90: UniRef90_A3Q4B9
UniRef50: UniRef50_A3Q4B9
UniParc: UPI00000D5010
EMBL: BX842583
EMBL: AE000516
EMBL-CDS: CAB05044.1
EMBL-CDS: AAK47997.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
HSSP: P51016
EnsemblGenome: EBMYCG00000000161
EnsemblGenome_TRS: EBMYCT00000000161
EnsemblGenome_PRO: EBMYCP00000000161
EnsemblGenome: EBMYCG00000070781
EnsemblGenome_TRS: EBMYCT00000070786
EnsemblGenome_PRO: EBMYCP00000068845
GenomeReviews: AE000516_GR
G
Taxonomy ID 83332
Gene Starting Position 3972551
Gene Ending Position 3973591
Gene Strand (Orientation) -
Protein Name 4-hydroxy-2-ketovalerate aldolase
DNA Sequence 
>gi|57116681:3972551-3973591 Mycobacterium tuberculosis H37Rv, complete genome
GTCAATGCGTTACGGCCGCACCGCTATCCAGCTCGCGTTTGATTTCCAGCGCGATGTCGATGAGCTGGTC
TTCCTGGCCACCGATGAGCTTGCGCTGACCGGCCCGGTGCAACAGCGCCGACGCCGGCACGCCGTAGCGC
TCGGCCTGGCGGACCGCATGCTTGAGGAAGCTGGAGTAGACCCCGGAATACCCCATGATCAACGCGTTGC
GGTCGAGCAGACATTCGGCCGGCATGGCCGGGCGCACCACGTCCTCGGCGGCGTCGGCAATGTCGAAGAA
ATCAATGCCGGTCTTGACGCCGATCTTGTCGAACACCCCGATCAGCGCCTCGACCGGCGCGTTACCCGCC
CCGGCGCCGAAACGCCGGCAGGACCCGTCGATCTGCTTGGCGCCCGCGCGCACCGCCGCCACCGAATTGG
CCACCCCGAGACCGAGGTTCTCGTGCCCATGAAAGCCCACCTGGGCGTCTTCGCCGAGCTCGGCGACCAG
GGCCGACACCCGGTCGGCCACGCCGTCGAGCACCAGGGCACCGGCGGAGTCGACGACGTAGACACACTGG
CAGCCGGCGTCGGCCATGATGCGGGCCTGGGCGGCCAGTTTCTCCGGCGCAATGGTGTGGGCCATCATCA
AAAACCCGACGGTTTCCAGACCCAGTTCGCGGGCCAGCCCGAAATGCTGGATCGACACGTCGGCCTCGGT
GCAGTGGGTGGCGATCCGGCAGATCGACCCGCCGTTGTCCCGCGCCTCTTTGATGTCGTCCTTGGTGCCC
ACACCGGGCAACATCAAAAACGCGATCCGGGCCTCTTTCGCGGTCGCCGCGGCCAGCTTGATCAGCTCCT
GCTCAGGGGTTTTCGAGAAGCCATAGTTGAACGATGAGCCGCCCAGGCCGTCGCCGTGGGTCACCTCGAT
CACCGGCACGCCAGCGGCGTCTAGGGCGGCCACGATGGCACCGACCTCGTCCTTGGTGAATTGGTGGCGT
TTGTGGTGCGACCCATCCCGCAGCGAGGTGTCCGTGATGCGGACGTCCCACATATCGGTCA
Protein Sequence 
>gi|15610670|ref|NP_218051.1| 4-hydroxy-2-oxovalerate aldolase [Mycobacterium tuberculosis H37Rv] MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG0119E, under E: Amino acid transport and metabolism
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].