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prrA from Mycobacterium tuberculosis H37Rv

Victor ID 90
Gene Name prrA from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885209
NCBI Protein GI 15608043
Locus Tag Rv0903c
Protein Accession NP_215418.1
Other Database IDs UniProtKB-ID: PRRA_MYCTU
UniRef100: UniRef100_P0A5Z7
UniRef90: UniRef90_P0A5Z7
UniRef50: UniRef50_P0A5Z7
UniParc: UPI00001BBB64
EMBL: BX842574
EMBL: AE000516
EMBL-CDS: CAA97378.1
EMBL-CDS: AAK45173.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 1YS6
PDB: 1YS7
DIP: DIP-29035N
EnsemblGenome: EBMYCG00000002157
EnsemblGenome_TRS: EBMYCT00000002159
EnsemblGenome_PRO: EBMYCP00000002159
EnsemblGenome: EBMYCG00000072503
EnsemblGenome_TRS: EBMYCT00000072508
EnsemblGenome_PRO: EBMYCP00000070567
Geno
Taxonomy ID 83332
Gene Starting Position 1005851
Gene Ending Position 1006561
Gene Strand (Orientation) -
Protein Name TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA
DNA Sequence 
>gi|57116681:1005851-1006561 Mycobacterium tuberculosis H37Rv, complete genome
GTCACTGCATACGCAGCACGAATCCGACTCCGCGGACGGTATGCAGCAGCCTAGGGCCACCGCCGGCCTC
CAGTTTGCGCCGCAGGTACCCGATGAAGACGTCCACCACGTTGGTGTCGGCGGCGAAGTCGTAGCCCCAC
ACCAATTCCAGGAGTTGCGCTCGGGAGAGCACCGCGGTCTTGTGCTCGGCCAGCACCGCGAGCAGGTCGA
ATTCGCGCTTGGTCAGGTCGACGTCGACGCCGTTGACCCGGGCCCGCCGGCCGGGGATGTCCACCTCCAG
CGGGCCCACCGTGATGGTTTCCGAGGACGACGTTGCAGTGGAGCCGCGGCGGCGCAGCAGCGCCTTCACC
CGTGCCACCAGCTCGGCCAGCACGAACGGTTTCACCAGGTAATCGTCGGCGCCGGCCTCCAATCCGGCCA
CTCGGTCATCGACAGAGCTGCGTGCGGATAGCACACAGACCGGGACGTCGTTGTCCATCGCGCGTAGTGC
CGTCACGACGCTGACTCCATCGAGCACTGGCATGTTGATGTCGAGCACGATCGCGTCCGGCCGGTTCTCG
GTGGCGCTGCGCAAGGCCTCGGCGCCGTCCACCGCGGTCGCTACCTCGAATCCGGACAGCCGTAAGCCGC
GTTCCAGCGAGGCGAGCACATCGGAGTCGTCGTCGACGACCAACACCCGAGGTGAGGTCACACCAGTGTC
CATGCCGCCCA
Protein Sequence 
>gi|15608043|ref|NP_215418.1| two component transcriptional regulator PrrA [Mycobacterium tuberculosis H37Rv] MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: prrA mutant is attenuated in murine macrophages (Ewann et al., 2002).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Ewann et al., 2002: Ewann F, Jackson M, Pethe K, Cooper A, Mielcarek N, Ensergueix D, Gicquel B, Locht C, Supply P. Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis. Infection and immunity. 2002; 70(5); 2256-2263. [PubMed: 11953357].