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devR from Mycobacterium tuberculosis H37Rv

Victor ID 341
Gene Name devR from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888842
NCBI Protein GI 15610269
Locus Tag Rv3133c
Protein Accession NP_217649.1
Other Database IDs UniProtKB-ID: DEVR_MYCTU
UniRef100: UniRef100_P95193
UniRef90: UniRef90_P95193
UniRef50: UniRef50_P95193
UniParc: UPI00000BFDEE
EMBL: U22037
EMBL: AE000516
EMBL: BX842582
EMBL-CDS: AAD17452.1
EMBL-CDS: AAK47557.1
EMBL-CDS: CAB06281.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 1ZLJ
PDB: 1ZLK
PDB: 3C3W
PDB: 3C57
EnsemblGenome: EBMYCG00000000635
EnsemblGenome_TRS: EBMYCT00000000635
EnsemblGenome_PRO: EBMYCP00000000635
EnsemblGenome: EBMYCG00000072445
EnsemblGenome_TRS: EBMYCT00000072450
Ens
Taxonomy ID 83332
Gene Starting Position 3499261
Gene Ending Position 3499914
Gene Strand (Orientation) -
Protein Name TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY)
DNA Sequence 
>gi|57116681:3499261-3499914 Mycobacterium tuberculosis H37Rv, complete genome
GTCATGGTCCATCACCGGGTGGCCGCGAGCGCTTCAACTCCGTCGCGAATACCGCGGCTTGCGTCCGACG
TTCCATGCCCAGCTTGGCCAGCAACCGCGACACGTAGTTCTTCACCGTCTTTTCGGCTAGGAACATTCGG
TCGGCGATCTGCTTGTTGGTCAGGCCCTCGCTAAGCAGGCCCAGTAGCGTCCGCTCCTGGTCGGTAAGGC
CTGATAGCGGGTCCTGCTTCTCGGCGGCACCGCGCAGCTTGGCCATCAGCGCGGCCGCGGCCCGATTGTC
CAGCAGCGACCGTCCAGCGCCCACATCTTTGACGGCGCGCGCCAACTCCATTCCCTTGATGTCTTTGACG
ACATATCCGCTGGCACCGGCGAGAATCGCATCTAGCATGGCCTCGTCAGAGGTGTAGGACGTGAGGATCA
GACAGCGCAGATCGGGCATGCGGGACAACAGATCGCGGCACAGTTCAATGCCGTTGCCATCGGGCAACCG
GACATCCAGCACCGCGACATCTGGGCGCGCGGCAGGAACCCTGGCCATCGCCTCGGCGACCGAACCCGCC
TCACCTACGACGTCAAGCTCGGGATCGGCCCCAAGCAAGTCAACCAGACCACGACGCACCACCTCGTGGT
CATCGACCAAGAAGACCTTTACCA
Protein Sequence 
>gi|15610269|ref|NP_217649.1| two component transcriptional regulator DevR [Mycobacterium tuberculosis H37Rv] MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: devR mutant is attenuated in guinea pigs (Malhotra et al., 2004).
COG COG2197TK, under T: Signal transduction mechanisms; K: Transcription
References
Malhotra et al., 2004: Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, Chakravorty S, Das TK, Li Q, Silver RF, Narayanan PR, Tyagi JS. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS microbiology letters. 2004; 231(2); 237-245. [PubMed: 14987770].