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sigE from Mycobacterium tuberculosis H37Ra

Victor ID 1901
Gene Name sigE from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215382
NCBI Protein GI 148661008
Locus Tag MRA_1230
Protein Accession YP_001282531.1
Other Database IDs UniProtKB-ID: A5U1R9_MYCTA
UniRef100: UniRef100_A1KI09
UniRef90: UniRef90_A1KI09
UniRef50: UniRef50_A0QCH1
UniParc: UPI000004B71F
EMBL: CP000611
EMBL-CDS: ABQ72969.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066236.
EnsemblGenome_TRS: EBMYCT00000066241
EnsemblGenome_PRO: EBMYCP00000064351
GenomeReviews: CP000611_GR
KEGG: mra:MRA_1230
eggNOG: COG1595
HOGENOM: HBG753452
OMA: NRIRMEA
ProtClustDB: PRK09647
BioCyc: MTUB419947:MRA_1230-MONOMER
Taxonomy ID 419947
Gene Starting Position 1365722
Gene Ending Position 1366495
Gene Strand (Orientation) +
Protein Name RNA polymerase sigma factor SigE
DNA Sequence 
>gi|148659757:1365722-1366495 Mycobacterium tuberculosis H37Ra, complete genome
CATGGAACTCCTCGGCGGACCCCGGGTTGGGAATACGGAATCGCAACTTTGCGTTGCCGACGGTGACGAC
TTGCCAACTTATTGCAGTGCAAATTCGGAGGATCTCAATATCACGACCATCACGACCTTGAGTCCGACCA
GCATGTCTCATCCCCAACAGGTCCGCGATGACCAGTGGGTGGAGCCGTCTGACCAATTGCAGGGCACCGC
CGTATTCGACGCCACCGGGGACAAGGCCACCATGCCGTCCTGGGATGAGCTGGTCCGTCAGCACGCCGAT
CGGGTGTACCGGCTGGCTTATCGGCTCTCCGGCAACCAGCACGATGCCGAAGACCTGACCCAGGAGACCT
TTATCAGGGTGTTCCGGTCGGTCCAGAATTACCAGCCGGGCACCTTCGAAGGCTGGCTACACCGCATCAC
CACCAACTTGTTCCTGGACATGGTCCGCCGCCGGGCTCGCATCCGGATGGAGGCGTTACCCGAGGACTAC
GACCGGGTGCCCGCCGATGAGCCCAACCCCGAGCAGATCTACCACGACGCACGGCTGGGACCTGACCTGC
AGGCTGCCTTGGCCTCGCTGCCGCCGGAGTTTCGTGCCGCGGTGGTGCTGTGTGACATCGAGGGTCTGTC
GTACGAGGAGATCGGCGCCACACTGGGCGTGAAGCTCGGGACGGTACGTAGCCGGATACACCGCGGACGC
CAGGCACTGCGGGACTACCTGGCAGCGCACCCCGAACATGGCGAGTGCGCAGTTCACGTCAACCCAGTTC
GCTG
Protein Sequence 
>gi|148661008|ref|YP_001282531.1| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis H37Ra] MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type (Manganelli et al., 2001).
COG COG1595K, under K: Transcription
References
Manganelli et al., 2001: Manganelli R, Voskuil MI, Schoolnik GK, Smith I. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Molecular microbiology. 2001; 41(2); 423-437. [PubMed: 11489128].