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regX3 from Mycobacterium tuberculosis H37Rv

Victor ID 236
Gene Name regX3 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887195
NCBI Protein GI 15607632
Locus Tag Rv0491
Protein Accession NP_215005.1
Other Database IDs UniProtKB-ID: REGX3_MYCTU
UniRef100: UniRef100_O07130
UniRef90: UniRef90_O07130
UniRef50: UniRef50_Q9F868
UniParc: UPI0000133841
EMBL: Y13628
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAA73958.1
EMBL-CDS: CAB00952.1
EMBL-CDS: AAK44733.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 2OQR
EnsemblGenome: EBMYCG00000001447
EnsemblGenome_TRS: EBMYCT00000001447
EnsemblGenome_PRO: EBMYCP00000001447
EnsemblGenome: EBMYCG00000072061
EnsemblGenome_TRS: EBMYCT00000072066
EnsemblGenome_PRO: EBMYCP0000007
Taxonomy ID 83332
Gene Starting Position 580808
Gene Ending Position 581491
Gene Strand (Orientation) +
Protein Name TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY)
DNA Sequence 
>gi|57116681:580808-581491 Mycobacterium tuberculosis H37Rv, complete genome
GATGACCAGTGTGTTGATTGTGGAGGACGAGGAGTCGCTGGCCGATCCGCTGGCGTTTCTGCTGCGCAAG
GAGGGCTTTGAGGCCACGGTGGTGACCGATGGTCCGGCAGCTCTCGCCGAGTTCGACCGGGCCGGCGCCG
ACATCGTCCTGCTCGATCTGATGCTGCCTGGGATGTCGGGTACCGATGTATGCAAGCAGTTGCGCGCTCG
GTCCAGCGTTCCGGTGATCATGGTGACCGCCCGGGATAGCGAGATCGACAAGGTGGTCGGCCTGGAGCTG
GGCGCTGACGACTACGTGACCAAGCCCTATTCGGCACGCGAGTTGATCGCACGCATCCGCGCGGTGCTGC
GCCGTGGCGGCGACGACGACTCGGAGATGAGCGATGGCGTGCTGGAGTCCGGGCCGGTTCGCATGGATGT
GGAGCGCCATGTCGTCTCGGTGAACGGTGACACCATCACGCTGCCGCTCAAGGAGTTCGACCTGCTGGAA
TACCTGATGCGCAACAGCGGGCGGGTGTTGACTCGCGGACAACTGATCGACCGGGTCTGGGGTGCGGACT
ACGTGGGCGACACCAAGACGCTCGACGTCCATGTCAAGCGGCTGCGCTCCAAGATCGAAGCCGACCCGGC
TAACCCGGTTCACTTGGTGACGGTGCGCGGGCTGGGCTACAAACTCGAGGGCTA
Protein Sequence 
>gi|15607632|ref|NP_215005.1| two component sensory transduction protein RegX [Mycobacterium tuberculosis H37Rv] MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRAGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Parish et al., 2003: Parish T, Smith DA, Roberts G, Betts J, Stoker NG. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, England). 2003; 149(Pt 6); 1423-1435. [PubMed: 12777483].