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Rv3649

Victor ID 125
Gene Name Rv3649
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885841
NCBI Protein GI 15610785
Locus Tag Rv3649
Protein Accession NP_218166.1
Other Database IDs UniProtKB-ID: O06359_MYCTU
UniRef100: UniRef100_A5U8X3
UniRef90: UniRef90_A5U8X3
UniRef50: UniRef50_C5CCU5
UniParc: UPI00000D4F38
EMBL: BX842583
EMBL-CDS: CAB08839.1
RefSeq_NT: NC_000962.2
EnsemblGenome: EBMYCG00000002225.
EnsemblGenome_TRS: EBMYCT00000002227
EnsemblGenome_PRO: EBMYCP00000002227
GenomeReviews: AL123456_GR
KEGG: mtu:Rv3649
TubercuList: Rv3649
HOGENOM: HBG402483
OMA: ATCDRWD
ProtClustDB: CLSK792622
Taxonomy ID 83332
Gene Starting Position 4088780
Gene Ending Position 4091095
Gene Strand (Orientation) +
Protein Name PROBABLE HELICASE
DNA Sequence 
>gi|57116681:4088780-4091095 Mycobacterium tuberculosis H37Rv, complete genome
AATGGCGAGTTTCGGCAGCCACCTGCTGGCCGCAGCGGTCGCCGGGACCCCGCCGGGCGAGCGTCCGCTG
CGCCACGTCGCCGAGCTGCCACCGCAGGCCGGCCGGCCGCGCGGTTGGCCGGAGTGGGCCGAGCCCGACG
TGGTGGATGCGTTTGCCGACCGCGGCATCAGCTCGCCGTGGTCACACCAGGCTGAGGCCGCCGAGTTGGC
GTACGCCGGCCGCCACGTGGTGATAGGCACCGGCCCGGCGTCTGGAAAGTCGTTGGCCTATCAACTTCTC
GTGCTCAACGCGCTGGCAACCGACTCCCGGGCGCGTGCGCTGTATCTGTCGCCGACGAAGGCGCTCGGCC
ACGACCAGTTGCGCGCCGCACATGCGCTGGCGGCCGCGGTGCCACGGCTGGCTGACGTCGCGCCGACGGC
CTATGACGGCGACAGTCCCGACGAGGTGCGCCGCTTTGCCCGCGAGCGCTCCCGGTGGCTGTTCTCCAAC
CCGGAGATGACACACCTATCGGTGCTTCGAAACCATGCGCGCTGGGCTGTGCTGTTGCGGAATCTCCGCT
TTGTGATCGTCGACGAATGCCATTACTACCGTGGTGTTTTCGGCTCGAATGTGGCGATGGTACTGCGCCG
TTTACTACGGCTGTGCGCGCGCTACTCTGCGCACCCGACGGTGATCTTCGCCAGCGCGACAACGGCCTCG
CCGGGCGCGACGGCTGCCGACCTGATCGGCCAGCCGGTCGTGGAGGTCACCGAGGACGGCTCACCCCGGG
GGGCTCGCACGGTGGCATTGTGGGAGCCCGCGCTGCGGTCGGATGTGATCGGCGAGCACGGCGCCCCGGT
GCGACGCTCCGCCGGTGCCGAGGCGGCCCGGGTGATGGCCGACCTGATCGTCGAGGGAGCGCAGACCTTG
ACGTTCGTCCGATCGCGGCGCGCGGCGGAACTGACTGCACTGGGTGCCCGGGCGCGACTGGTCGACATTG
CCCCGGAACTGTCGGACACGGTGGCGTCGTATCGGGCCGGTTATCTTGCCGAGGACCGTAGCGCGCTGCA
CCAGGCCCTGGCCGAGGGCCAGCTGCGCGGGCTGGCTACCACCAACGCTTTGGAGTTGGGCGTTGATATC
GCCGGACTGGATGCGGTGGTGCTGGCTGGTTTTCCCGGGACGGTGGCCTCGTTCTGGCAGCAGGCGGGCC
GGTCGGGCCGGCGCGGCCAGGGCGCGCTGGTGGTGTTGATTGCCCGTGACGATCCGCTGGACACGTATTT
GGTCCACCATCCCGCAGCATTGTTGGACAAACCGGTCGAGCGCGTGGTGATCGATCCGGTTAACCCGCAC
CTGCTGGGTCCCCAATTGCTTTGTGCAGCAACAGAACTGCCTTTAGACGACGCCGAGGTCCGGTCCTGGG
GCGCCGTTGAGGTGGCGGAGAGTCTGGTTGACGACGGGCTGTTGCGGCGCCGGAACGGCAGGTACTTTCC
GGCGCCCGGGGTGAAACCGCATGCCGCCGTGGATGTCCGGGGGGCTATCGGTGGCCAGATCGTCATCGTG
GAGGCCGGAACCGGGCGGCTCTTGGGCAGCGTGGGCGTCGGTCAGGCCCCGGCCGCAGCGCACCCAGGCG
CGGTGTACCTGCACCAGGGCGAGACCTACGTCGTTGACTCGCTGGATTTCCAGGACGGAATCGCCTTCGT
GCACGCCGAGGATCCCGGCTATGCCACGTTCGCGCGAGAGGTCACCGACATCGCGGTCACCGGCACCGGC
GAGCGGTTGGTCTTCGGGCCCGTTGCTTTGGGTTTGGTGCCGGTGACTGTCACCAATCACGTCGTCGGCT
ACCTGCGCCGCCAGCTGTCCGGGGAGGTGCTGGACTTCGTGGAGCTGGACATGCCGGAACACACCTTGCC
CACAACCGCGGTCATGTACACAATCACTTCGGATGCATTGGTCCGCAGCGGTATTGAGGCCACACGGATT
CCCGGGTCGTTGCACGCCGCCGAACACGCGGCCATCGGGCTGCTGCCGCTGGTGGCCAGCTGCGACCGCG
GCGATATCGGCGGCATGTCCACAGCGACCGGGCCCGAGGGGCTGCCCAGTGTCTTTGTCTACGACGGCTA
TCCGGGTGGAGCCGGATTCGCCGAACGCGGCTTTCGCCGGGCCCGCACCTGGCTGGGCGCCACCGCGGAG
GCCATCGAAGCCTGCGAATGCCCCAGTGGGTGTCCATCGTGTGTGCAATCCCCCAAGTGCGGCAATGGCA
ACGACCCGTTAGACAAGGCGGGCGCGGTGCGGGTGCTGCGGCTGGTGCTCGCCGAGTTAAGTGAGGAATC
ACCGTG
Protein Sequence 
>gi|15610785|ref|NP_218166.1| helicase [Mycobacterium tuberculosis H37Rv] MASFGSHLLAAAVAGTPPGERPLRHVAELPPQAGRPRGWPEWAEPDVVDAFADRGISSPWSHQAEAAELAYAGRHVVIGTGPASGKSLAYQLLVLNALATDSRARALYLSPTKALGHDQLRAAHALAAAVPRLADVAPTAYDGDSPDEVRRFARERSRWLFSNPEMTHLSVLRNHARWAVLLRNLRFVIVDECHYYRGVFGSNVAMVLRRLLRLCARYSAHPTVIFASATTASPGATAADLIGQPVVEVTEDGSPRGARTVALWEPALRSDVIGEHGAPVRRSAGAEAARVMADLIVEGAQTLTFVRSRRAAELTALGARARLVDIAPELSDTVASYRAGYLAEDRSALHQALAEGQLRGLATTNALELGVDIAGLDAVVLAGFPGTVASFWQQAGRSGRRGQGALVVLIARDDPLDTYLVHHPAALLDKPVERVVIDPVNPHLLGPQLLCAATELPLDDAEVRSWGAVEVAESLVDDGLLRRRNGRYFPAPGVKPHAAVDVRGAIGGQIVIVEAGTGRLLGSVGVGQAPAAAHPGAVYLHQGETYVVDSLDFQDGIAFVHAEDPGYATFAREVTDIAVTGTGERLVFGPVALGLVPVTVTNHVVGYLRRQLSGEVLDFVELDMPEHTLPTTAVMYTITSDALVRSGIEATRIPGSLHAAEHAAIGLLPLVASCDRGDIGGMSTATGPEGLPSVFVYDGYPGGAGFAERGFRRARTWLGATAEAIEACECPSGCPSCVQSPKCGNGNDPLDKAGAVRVLRLVLAELSEESP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG1205R, under R: General function prediction only
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].