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proV

Victor ID 178
Gene Name proV
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886293
NCBI Protein GI 15610894
Locus Tag Rv3758c
Protein Accession NP_218275.1
Other Database IDs UniProtKB-ID: O69724_MYCTU
UniRef100: UniRef100_A1KQ89
UniRef90: UniRef90_A1KQ89
UniRef50: UniRef50_D6ZC78
UniParc: UPI00000D4FF5
EMBL: BX842584
EMBL-CDS: CAA18080.1
RefSeq_NT: NC_000962.2
HSSP: Q9YGA6
EnsemblGenome: EBMYCG00000001461.
EnsemblGenome_TRS: EBMYCT00000001461
EnsemblGenome_PRO: EBMYCP00000001461
GenomeReviews: AL123456_GR
KEGG: mtu:Rv3758c
TubercuList: Rv3758c
HOGENOM: HBG758042
OMA: RMVEPTS
ProtClustDB: CLSK792699
Taxonomy ID 83332
Gene Starting Position 4203286
Gene Ending Position 4204416
Gene Strand (Orientation) -
Protein Name POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV
DNA Sequence 
>gi|57116681:4203286-4204416 Mycobacterium tuberculosis H37Rv, complete genome
ATCAGGTAGTGCATGGCTTAGCTCCGCCGCCGGCCTTCTTGCCTTTTTGGAACTCGGCCAGCACGTCGGC
GGCCAGTATCCCGCCGATGACCTTGCCACCGCCGTCAACGGCGACACCGACCCCCGACGGCGAGGACAAG
GCGGCGTCCAGCGCCTGGCTGAGGTTACCGTTCGGGCGGAACACCGAACCGCCGACGGTCATGGCATCCG
ACAATGCCGCGCCGCCGCGGTGACGCCGCCGGCCATCGGCGTCGATCCAGCCCAACGGCGCACCCGCACC
GTCGACCACCAGCACCCAGCCGTCACGAACTTGCCTGTCCCGGGCATCGGAAAGGCCGTTCACCGAGACT
TGCTCGATGTCGCGCACAGGTAGTCCGGCCGCGTCGAACAGCTGCAGCCACCGATAGCCGCGACCGAGAC
CGATGAACTTCGACACGAAGTCATTCGCCGGACTGGATAACAGCCGGGCAGTTTCGTCGTACTGCGCAAG
CGCGCCGCCCGGGGCGAACACCGCCACCAGATCGGCGAGCTTCAACGCCTCGTCGATGTCGTGCGTCACG
AAGACAATGGTCTTGTGCAACTCGGCTTGCAGACGAAGTATTTCGTTCTGTAGCTCGTGGCGAACCACCG
GGTCGACGGCCGAGAACGGCTCGTCCATCAACAAGATCGGCGGATCGGCCGCGAGTGCCCGTGCCACGCC
GACCCGTTGCTGTTCGCCGCCCGAGAGCTGGGCCGGGTAGCGGGTGGCGACCTTGGGGTCCAGCCCGACA
CGCTCAAGCACCTCATAACCGGCTTTGCGGGCTGCCCGGCGCGGCTGACCCTTCAGCACCGGCACCGTTG
CGACGTTGTCGATGACCCGTTGATGAGGCATCAGCCCCGCGTTCTGGATGACATAGCCAATTCCCAGGCG
CAGCTTCACCGCATTGACCGTCGACACGTCGGTACCGTCGACAGTGATGGTGCCCGAGGTCGGATCCACC
ATTCGGTTGATCATTCGCAGCGCCGTCGTCTTGCCGCAGCCGGAGGGGCCGACGAAGACGGTCAGCATGC
CGTTAGGGACTTCCAGCGTCAGCCGGTCTACGGCGGTGGCACCGTGTGCGTACACCTTGCTGACATCGTC
AAAGCAGATCA
Protein Sequence 
>gi|15610894|ref|NP_218275.1| glycine betaine/carnitine/choline/L-proline ABC transporter ATP-binding protein ProV [Mycobacterium tuberculosis H37Rv] MICFDDVSKVYAHGATAVDRLTLEVPNGMLTVFVGPSGCGKTTALRMINRMVDPTSGTITVDGTDVSTVNAVKLRLGIGYVIQNAGLMPHQRVIDNVATVPVLKGQPRRAARKAGYEVLERVGLDPKVATRYPAQLSGGEQQRVGVARALAADPPILLMDEPFSAVDPVVRHELQNEILRLQAELHKTIVFVTHDIDEALKLADLVAVFAPGGALAQYDETARLLSSPANDFVSKFIGLGRGYRWLQLFDAAGLPVRDIEQVSVNGLSDARDRQVRDGWVLVVDGAGAPLGWIDADGRRRHRGGAALSDAMTVGGSVFRPNGNLSQALDAALSSPSGVGVAVDGGGKVIGGILAADVLAEFQKGKKAGGGAKPCTT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG1125E, under E: Amino acid transport and metabolism
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].